Vascular actions of natriuretic peptides View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-01-23

AUTHORS

Amrita Ahluwalia, Raymond J. MacAllister, Adrian J. Hobbs

ABSTRACT

.Natriuretic peptides play important roles in the regulation of cardiovascular homeostasis. The endocrine actions of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) complement the paracrine effects of C-type natriuretic peptide (CNP) and urodilatin to regulate vascular smooth muscle tone, fluid and electrolyte balance and cardiac morphology. As a consequence, aberrant natriuretic peptide production and/or activity have been linked to a number of cardiovascular disorders and interventions that selectively modulate these vasoactive peptides may be of therapeutic benefit. This review will outline the structure, expression and vascular actions of natriuretic peptides and their endogenous receptors and highlight recent work that has revealed important interactions between the cyclic GMP producing particulate and soluble guanylate cyclases, thereby linking the cardiovascular actions of natriuretic peptides and nitric oxide, and a role for CNP as an endothelium-derived hyperpolarising factor (EDHF). More... »

PAGES

83-89

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00395-004-0459-6

DOI

http://dx.doi.org/10.1007/s00395-004-0459-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049123989

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/14963666


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