A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-11-27

AUTHORS

Lars Libuda, Roaa Naaresh, Christine Ludwig, Björn-Hergen Laabs, Jochen Antel, Manuel Föcker, Johannes Hebebrand, Anke Hinney, Triinu Peters

ABSTRACT

BackgroundWhile observational studies revealed an inverse association between serum 25(OH)vitamin D (25(OH)D) and the risk of attention deficit/hyperactivity disorder (ADHD), the causality of this relationship remains unclear.MethodsWe conducted a bidirectional two-sample Mendelian Randomization (MR) study to examine whether 25(OH)D has an effect on the risk to develop ADHD or vice versa. Information on single nucleotide polymorphisms (SNP) associated with serum 25(OH)D was obtained from a genome-wide association study (GWAS) considering phenotype data from 79,366 individuals of European ancestry. Data on risk for ADHD were derived from a GWAS analysis with 20,183 individuals diagnosed with ADHD and 35,191 controls. For our analysis, we considered effect sizes based on the European participants (19,099 cases and 34,194 controls).ResultsSingle SNP analyses showed a causal effect of vitamin D on ADHD risk for only one SNP (rs12785878, p = 0.024). The overall MR estimates did not reveal a causal effect of 25(OH)D on risk for ADHD. In the reverse analysis, neither any single nor the multi-SNP MR analyses showed a causal effect of ADHD on 25(OH)D.ConclusionResults from this two-sample MR study did not confirm a causal effect of 25(OH)D on ADHD or vice versa. Accordingly, our study does not provide evidence that improving 25(OH)D via supplementation could reduce the risk of developing ADHD. More... »

PAGES

2581-2591

References to SciGraph publications

  • 2017-02-08. Vitamin D and mental health in children and adolescents in EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
  • 2018-10-26. Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD): a meta-analysis in ADHD ATTENTION DEFICIT AND HYPERACTIVITY DISORDERS
  • 2018-04-23. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases in NATURE GENETICS
  • 2018-01-17. Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels in NATURE COMMUNICATIONS
  • 2020-04-02. Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration in NATURE COMMUNICATIONS
  • 2016-09-05. Ernährung und Bewegung von Säuglingen und stillenden Frauen in MONATSSCHRIFT KINDERHEILKUNDE
  • 2018-11-26. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder in NATURE GENETICS
  • 2017-05-19. Interpreting findings from Mendelian randomization using the MR-Egger method in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2017-11-22. Recent Developments in Mendelian Randomization Studies in CURRENT EPIDEMIOLOGY REPORTS
  • 2019-05-06. Vitamin D supplementation after the second year of life: joint position of the Committee on Nutrition, German Society for Pediatric and Adolescent Medicine (DGKJ e.V.), and the German Society for Pediatric Endocrinology and Diabetology (DGKED e.V.) in MOLECULAR AND CELLULAR PEDIATRICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00394-020-02439-2

    DOI

    http://dx.doi.org/10.1007/s00394-020-02439-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1132965529

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/33245439


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Public Health and Health Services", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Attention Deficit Disorder with Hyperactivity", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Genome-Wide Association Study", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mendelian Randomization Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Polymorphism, Single Nucleotide", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Vitamin D", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Research Institute for the Prevention of Allergies and Respiratory Diseases in Childhood, Department of Pediatrics, Marien-Hospital Wesel, 46483, Wesel, Germany", 
              "id": "http://www.grid.ac/institutes/grid.488381.e", 
              "name": [
                "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany", 
                "Research Institute for the Prevention of Allergies and Respiratory Diseases in Childhood, Department of Pediatrics, Marien-Hospital Wesel, 46483, Wesel, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Libuda", 
            "givenName": "Lars", 
            "id": "sg:person.0742320465.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742320465.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5718.b", 
              "name": [
                "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naaresh", 
            "givenName": "Roaa", 
            "id": "sg:person.010270303541.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010270303541.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5718.b", 
              "name": [
                "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ludwig", 
            "givenName": "Christine", 
            "id": "sg:person.014603033341.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014603033341.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Institut f\u00fcr Medizinische Biometrie und Statistik, Universit\u00e4t zu L\u00fcbeck, Universit\u00e4tsklinikum Schleswig-Holstein, 23562, L\u00fcbeck, Germany", 
              "id": "http://www.grid.ac/institutes/grid.4562.5", 
              "name": [
                "Institut f\u00fcr Medizinische Biometrie und Statistik, Universit\u00e4t zu L\u00fcbeck, Universit\u00e4tsklinikum Schleswig-Holstein, 23562, L\u00fcbeck, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Laabs", 
            "givenName": "Bj\u00f6rn-Hergen", 
            "id": "sg:person.010427360515.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010427360515.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5718.b", 
              "name": [
                "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Antel", 
            "givenName": "Jochen", 
            "id": "sg:person.015744240364.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015744240364.49"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Child and Adolescent Psychiatry, University of M\u00fcnster, 48149, M\u00fcnster, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5949.1", 
              "name": [
                "Department of Child and Adolescent Psychiatry, University of M\u00fcnster, 48149, M\u00fcnster, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "F\u00f6cker", 
            "givenName": "Manuel", 
            "id": "sg:person.0704254754.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704254754.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5718.b", 
              "name": [
                "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hebebrand", 
            "givenName": "Johannes", 
            "id": "sg:person.01266642064.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266642064.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5718.b", 
              "name": [
                "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hinney", 
            "givenName": "Anke", 
            "id": "sg:person.01166020076.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166020076.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany", 
              "id": "http://www.grid.ac/institutes/grid.5718.b", 
              "name": [
                "Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Peters", 
            "givenName": "Triinu", 
            "id": "sg:person.010425000605.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010425000605.69"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/s41588-018-0269-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1110155380", 
              "https://doi.org/10.1038/s41588-018-0269-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-017-02662-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100320496", 
              "https://doi.org/10.1038/s41467-017-02662-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10654-017-0255-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085444144", 
              "https://doi.org/10.1007/s10654-017-0255-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40348-019-0090-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1113937516", 
              "https://doi.org/10.1186/s40348-019-0090-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s40471-017-0128-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092840571", 
              "https://doi.org/10.1007/s40471-017-0128-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-020-15421-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1126049488", 
              "https://doi.org/10.1038/s41467-020-15421-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00787-017-0949-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083698310", 
              "https://doi.org/10.1007/s00787-017-0949-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41588-018-0099-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103565841", 
              "https://doi.org/10.1038/s41588-018-0099-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12402-018-0276-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107869882", 
              "https://doi.org/10.1007/s12402-018-0276-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00112-016-0173-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039017019", 
              "https://doi.org/10.1007/s00112-016-0173-0"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2020-11-27", 
        "datePublishedReg": "2020-11-27", 
        "description": "BackgroundWhile observational studies revealed an inverse association between serum 25(OH)vitamin D (25(OH)D) and the risk of attention deficit/hyperactivity disorder (ADHD), the causality of this relationship remains unclear.MethodsWe conducted a bidirectional two-sample Mendelian Randomization (MR) study to examine whether 25(OH)D has an effect on the risk to develop ADHD or vice versa. Information on single nucleotide polymorphisms (SNP) associated with serum 25(OH)D was obtained from a genome-wide association study (GWAS) considering phenotype data from 79,366 individuals of European ancestry. Data on risk for ADHD were derived from a GWAS analysis with 20,183 individuals diagnosed with ADHD and 35,191 controls. For our analysis, we considered effect sizes based on the European participants (19,099 cases and 34,194 controls).ResultsSingle SNP analyses showed a causal effect of vitamin D on ADHD risk for only one SNP (rs12785878, p\u2009=\u20090.024). The overall MR estimates did not reveal a causal effect of 25(OH)D on risk for ADHD. In the reverse analysis, neither any single nor the multi-SNP MR analyses showed a causal effect of ADHD on 25(OH)D.ConclusionResults from this two-sample MR study did not confirm a causal effect of 25(OH)D on ADHD or vice versa. Accordingly, our study does not provide evidence that improving 25(OH)D via supplementation could reduce the risk of developing ADHD.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00394-020-02439-2", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1294989", 
            "issn": [
              "1436-6207", 
              "1436-6215"
            ], 
            "name": "European Journal of Nutrition", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "5", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "60"
          }
        ], 
        "keywords": [
          "attention-deficit/hyperactivity disorder", 
          "Mendelian randomization study", 
          "deficit/hyperactivity disorder", 
          "single nucleotide polymorphisms", 
          "randomization study", 
          "hyperactivity disorder", 
          "two-sample Mendelian randomization study", 
          "two-sample MR study", 
          "vitamin D", 
          "D levels", 
          "inverse association", 
          "observational study", 
          "genome-wide association studies", 
          "MR studies", 
          "MR analysis", 
          "ADHD risk", 
          "risk", 
          "MR estimates", 
          "effect size", 
          "European ancestry", 
          "serum", 
          "disorders", 
          "European participants", 
          "nucleotide polymorphisms", 
          "causal effect", 
          "association studies", 
          "study", 
          "MethodsWe", 
          "individuals", 
          "supplementation", 
          "effect", 
          "ConclusionResults", 
          "SNP analysis", 
          "association", 
          "participants", 
          "polymorphism", 
          "evidence", 
          "analysis", 
          "levels", 
          "data", 
          "control", 
          "phenotype data", 
          "ancestry", 
          "relationship", 
          "GWAS analysis", 
          "causality", 
          "information", 
          "vice", 
          "size", 
          "estimates", 
          "reverse analysis"
        ], 
        "name": "A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder", 
        "pagination": "2581-2591", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1132965529"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00394-020-02439-2"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "33245439"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00394-020-02439-2", 
          "https://app.dimensions.ai/details/publication/pub.1132965529"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-09-02T16:04", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_851.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00394-020-02439-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00394-020-02439-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00394-020-02439-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00394-020-02439-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00394-020-02439-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    242 TRIPLES      21 PREDICATES      92 URIs      74 LITERALS      13 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00394-020-02439-2 schema:about N2f18a04b905440cd8b9f4630369a26ca
    2 N3b3a1c866f5c4b92acdad9ac545cbf23
    3 N41d03f8d47b845df8522a2b5491827b3
    4 N4bf0fb1663224e4fa02f1f119d9daeac
    5 N52709ac57742424f8be58542388c26aa
    6 N69eadfc043474422a021917718ffc7b8
    7 anzsrc-for:11
    8 anzsrc-for:1117
    9 schema:author N20394aa3afe9471ab2beaeca68f354fa
    10 schema:citation sg:pub.10.1007/s00112-016-0173-0
    11 sg:pub.10.1007/s00787-017-0949-3
    12 sg:pub.10.1007/s10654-017-0255-x
    13 sg:pub.10.1007/s12402-018-0276-7
    14 sg:pub.10.1007/s40471-017-0128-6
    15 sg:pub.10.1038/s41467-017-02662-2
    16 sg:pub.10.1038/s41467-020-15421-7
    17 sg:pub.10.1038/s41588-018-0099-7
    18 sg:pub.10.1038/s41588-018-0269-7
    19 sg:pub.10.1186/s40348-019-0090-0
    20 schema:datePublished 2020-11-27
    21 schema:datePublishedReg 2020-11-27
    22 schema:description BackgroundWhile observational studies revealed an inverse association between serum 25(OH)vitamin D (25(OH)D) and the risk of attention deficit/hyperactivity disorder (ADHD), the causality of this relationship remains unclear.MethodsWe conducted a bidirectional two-sample Mendelian Randomization (MR) study to examine whether 25(OH)D has an effect on the risk to develop ADHD or vice versa. Information on single nucleotide polymorphisms (SNP) associated with serum 25(OH)D was obtained from a genome-wide association study (GWAS) considering phenotype data from 79,366 individuals of European ancestry. Data on risk for ADHD were derived from a GWAS analysis with 20,183 individuals diagnosed with ADHD and 35,191 controls. For our analysis, we considered effect sizes based on the European participants (19,099 cases and 34,194 controls).ResultsSingle SNP analyses showed a causal effect of vitamin D on ADHD risk for only one SNP (rs12785878, p = 0.024). The overall MR estimates did not reveal a causal effect of 25(OH)D on risk for ADHD. In the reverse analysis, neither any single nor the multi-SNP MR analyses showed a causal effect of ADHD on 25(OH)D.ConclusionResults from this two-sample MR study did not confirm a causal effect of 25(OH)D on ADHD or vice versa. Accordingly, our study does not provide evidence that improving 25(OH)D via supplementation could reduce the risk of developing ADHD.
    23 schema:genre article
    24 schema:isAccessibleForFree true
    25 schema:isPartOf N10abeb2f34dc4d6d9d1721b2f57b0692
    26 N5fcfed14388a488b8c74eb76b7498e47
    27 sg:journal.1294989
    28 schema:keywords ADHD risk
    29 ConclusionResults
    30 D levels
    31 European ancestry
    32 European participants
    33 GWAS analysis
    34 MR analysis
    35 MR estimates
    36 MR studies
    37 Mendelian randomization study
    38 MethodsWe
    39 SNP analysis
    40 analysis
    41 ancestry
    42 association
    43 association studies
    44 attention-deficit/hyperactivity disorder
    45 causal effect
    46 causality
    47 control
    48 data
    49 deficit/hyperactivity disorder
    50 disorders
    51 effect
    52 effect size
    53 estimates
    54 evidence
    55 genome-wide association studies
    56 hyperactivity disorder
    57 individuals
    58 information
    59 inverse association
    60 levels
    61 nucleotide polymorphisms
    62 observational study
    63 participants
    64 phenotype data
    65 polymorphism
    66 randomization study
    67 relationship
    68 reverse analysis
    69 risk
    70 serum
    71 single nucleotide polymorphisms
    72 size
    73 study
    74 supplementation
    75 two-sample MR study
    76 two-sample Mendelian randomization study
    77 vice
    78 vitamin D
    79 schema:name A mendelian randomization study on causal effects of 25(OH)vitamin D levels on attention deficit/hyperactivity disorder
    80 schema:pagination 2581-2591
    81 schema:productId N8fedccb5e5f24e90b99d579f8b6632b5
    82 Na8b25946de7a4f7fb791cef33fd97694
    83 Nfeae951cb63e412bacf68140a5868bd4
    84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132965529
    85 https://doi.org/10.1007/s00394-020-02439-2
    86 schema:sdDatePublished 2022-09-02T16:04
    87 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    88 schema:sdPublisher N79f173a8cdcd41668f07c31fa6f715c6
    89 schema:url https://doi.org/10.1007/s00394-020-02439-2
    90 sgo:license sg:explorer/license/
    91 sgo:sdDataset articles
    92 rdf:type schema:ScholarlyArticle
    93 N10abeb2f34dc4d6d9d1721b2f57b0692 schema:volumeNumber 60
    94 rdf:type schema:PublicationVolume
    95 N20394aa3afe9471ab2beaeca68f354fa rdf:first sg:person.0742320465.63
    96 rdf:rest N56249c12fe4740a98dbd652d4a200049
    97 N2f18a04b905440cd8b9f4630369a26ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    98 schema:name Mendelian Randomization Analysis
    99 rdf:type schema:DefinedTerm
    100 N2f606eb044fb4e1bbf70d16d6107e988 rdf:first sg:person.0704254754.41
    101 rdf:rest Ne57cf61488854ece97ad600a7fa41291
    102 N35c43bc9fccd4f14a568e4399d89620e rdf:first sg:person.01166020076.17
    103 rdf:rest Nfb6a23c54993490da668f2bcc5a9c244
    104 N3b3a1c866f5c4b92acdad9ac545cbf23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    105 schema:name Humans
    106 rdf:type schema:DefinedTerm
    107 N41d03f8d47b845df8522a2b5491827b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Polymorphism, Single Nucleotide
    109 rdf:type schema:DefinedTerm
    110 N4bf0fb1663224e4fa02f1f119d9daeac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    111 schema:name Vitamin D
    112 rdf:type schema:DefinedTerm
    113 N52709ac57742424f8be58542388c26aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    114 schema:name Genome-Wide Association Study
    115 rdf:type schema:DefinedTerm
    116 N56249c12fe4740a98dbd652d4a200049 rdf:first sg:person.010270303541.75
    117 rdf:rest N8179f7a71da443a7b518af1f3d9ec225
    118 N5fcfed14388a488b8c74eb76b7498e47 schema:issueNumber 5
    119 rdf:type schema:PublicationIssue
    120 N69eadfc043474422a021917718ffc7b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Attention Deficit Disorder with Hyperactivity
    122 rdf:type schema:DefinedTerm
    123 N79f173a8cdcd41668f07c31fa6f715c6 schema:name Springer Nature - SN SciGraph project
    124 rdf:type schema:Organization
    125 N7d0f9277deae4165b607b07fcfc6d32f rdf:first sg:person.015744240364.49
    126 rdf:rest N2f606eb044fb4e1bbf70d16d6107e988
    127 N8179f7a71da443a7b518af1f3d9ec225 rdf:first sg:person.014603033341.38
    128 rdf:rest Ndcae175c8ef2466da2b2361646c2fd76
    129 N8fedccb5e5f24e90b99d579f8b6632b5 schema:name doi
    130 schema:value 10.1007/s00394-020-02439-2
    131 rdf:type schema:PropertyValue
    132 Na8b25946de7a4f7fb791cef33fd97694 schema:name dimensions_id
    133 schema:value pub.1132965529
    134 rdf:type schema:PropertyValue
    135 Ndcae175c8ef2466da2b2361646c2fd76 rdf:first sg:person.010427360515.53
    136 rdf:rest N7d0f9277deae4165b607b07fcfc6d32f
    137 Ne57cf61488854ece97ad600a7fa41291 rdf:first sg:person.01266642064.26
    138 rdf:rest N35c43bc9fccd4f14a568e4399d89620e
    139 Nfb6a23c54993490da668f2bcc5a9c244 rdf:first sg:person.010425000605.69
    140 rdf:rest rdf:nil
    141 Nfeae951cb63e412bacf68140a5868bd4 schema:name pubmed_id
    142 schema:value 33245439
    143 rdf:type schema:PropertyValue
    144 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    145 schema:name Medical and Health Sciences
    146 rdf:type schema:DefinedTerm
    147 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
    148 schema:name Public Health and Health Services
    149 rdf:type schema:DefinedTerm
    150 sg:journal.1294989 schema:issn 1436-6207
    151 1436-6215
    152 schema:name European Journal of Nutrition
    153 schema:publisher Springer Nature
    154 rdf:type schema:Periodical
    155 sg:person.010270303541.75 schema:affiliation grid-institutes:grid.5718.b
    156 schema:familyName Naaresh
    157 schema:givenName Roaa
    158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010270303541.75
    159 rdf:type schema:Person
    160 sg:person.010425000605.69 schema:affiliation grid-institutes:grid.5718.b
    161 schema:familyName Peters
    162 schema:givenName Triinu
    163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010425000605.69
    164 rdf:type schema:Person
    165 sg:person.010427360515.53 schema:affiliation grid-institutes:grid.4562.5
    166 schema:familyName Laabs
    167 schema:givenName Björn-Hergen
    168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010427360515.53
    169 rdf:type schema:Person
    170 sg:person.01166020076.17 schema:affiliation grid-institutes:grid.5718.b
    171 schema:familyName Hinney
    172 schema:givenName Anke
    173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166020076.17
    174 rdf:type schema:Person
    175 sg:person.01266642064.26 schema:affiliation grid-institutes:grid.5718.b
    176 schema:familyName Hebebrand
    177 schema:givenName Johannes
    178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266642064.26
    179 rdf:type schema:Person
    180 sg:person.014603033341.38 schema:affiliation grid-institutes:grid.5718.b
    181 schema:familyName Ludwig
    182 schema:givenName Christine
    183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014603033341.38
    184 rdf:type schema:Person
    185 sg:person.015744240364.49 schema:affiliation grid-institutes:grid.5718.b
    186 schema:familyName Antel
    187 schema:givenName Jochen
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015744240364.49
    189 rdf:type schema:Person
    190 sg:person.0704254754.41 schema:affiliation grid-institutes:grid.5949.1
    191 schema:familyName Föcker
    192 schema:givenName Manuel
    193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0704254754.41
    194 rdf:type schema:Person
    195 sg:person.0742320465.63 schema:affiliation grid-institutes:grid.488381.e
    196 schema:familyName Libuda
    197 schema:givenName Lars
    198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742320465.63
    199 rdf:type schema:Person
    200 sg:pub.10.1007/s00112-016-0173-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039017019
    201 https://doi.org/10.1007/s00112-016-0173-0
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1007/s00787-017-0949-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083698310
    204 https://doi.org/10.1007/s00787-017-0949-3
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1007/s10654-017-0255-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1085444144
    207 https://doi.org/10.1007/s10654-017-0255-x
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1007/s12402-018-0276-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107869882
    210 https://doi.org/10.1007/s12402-018-0276-7
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/s40471-017-0128-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092840571
    213 https://doi.org/10.1007/s40471-017-0128-6
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/s41467-017-02662-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100320496
    216 https://doi.org/10.1038/s41467-017-02662-2
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/s41467-020-15421-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1126049488
    219 https://doi.org/10.1038/s41467-020-15421-7
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/s41588-018-0099-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103565841
    222 https://doi.org/10.1038/s41588-018-0099-7
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/s41588-018-0269-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1110155380
    225 https://doi.org/10.1038/s41588-018-0269-7
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1186/s40348-019-0090-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113937516
    228 https://doi.org/10.1186/s40348-019-0090-0
    229 rdf:type schema:CreativeWork
    230 grid-institutes:grid.4562.5 schema:alternateName Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, 23562, Lübeck, Germany
    231 schema:name Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, 23562, Lübeck, Germany
    232 rdf:type schema:Organization
    233 grid-institutes:grid.488381.e schema:alternateName Research Institute for the Prevention of Allergies and Respiratory Diseases in Childhood, Department of Pediatrics, Marien-Hospital Wesel, 46483, Wesel, Germany
    234 schema:name Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany
    235 Research Institute for the Prevention of Allergies and Respiratory Diseases in Childhood, Department of Pediatrics, Marien-Hospital Wesel, 46483, Wesel, Germany
    236 rdf:type schema:Organization
    237 grid-institutes:grid.5718.b schema:alternateName Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany
    238 schema:name Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital Essen, University of Duisburg-Essen, Virchowstr. 174, 45147, Essen, Germany
    239 rdf:type schema:Organization
    240 grid-institutes:grid.5949.1 schema:alternateName Department of Child and Adolescent Psychiatry, University of Münster, 48149, Münster, Germany
    241 schema:name Department of Child and Adolescent Psychiatry, University of Münster, 48149, Münster, Germany
    242 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...