Inulin supplementation ameliorates hyperuricemia and modulates gut microbiota in Uox-knockout mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-10-26

AUTHORS

Yingjie Guo, Yanan Yu, Hailong Li, Xueli Ding, Xiaoyu Li, Xue Jing, Jianwei Chen, Guilin Liu, Yuan Lin, Chen Jiang, Zhen Liu, Yuwei He, Changgui Li, Zibin Tian

ABSTRACT

PurposeInulin is a type of fermentable dietary fiber, which is non-digestible, and can improve metabolic function by modulating intestinal microbiota. This study aimed to evaluate the role of inulin in hyperuricemia and microbial composition of the gut microbiota in a mouse model of hyperuricemia established through knockout of Uox (urate oxidase) gene.MethodsKO (Uox-knockout) and WT (wild-type) mice were given inulin or saline by gavage for 7 weeks. The effect of inulin to combat hyperuricemia was determined by assessing the changes in serum UA (uric acid) levels, inflammatory parameters, epithelial barrier integrity, fecal microbiota alterations, and SCFA (short-chain fatty acid) concentrations in KO mice.ResultsInulin supplementation can effectively alleviate hyperuricemia, increase the expressions of ABCG2 in intestine, and downregulate expression and activity of hepatic XOD (xanthine oxidase) in KO mice. It was revealed that the levels of inflammatory cytokines and the LPS (lipopolysaccharide) were remarkably higher in the KO group than those in the WT group, indicating systemic inflammation of hyperuricemic mice, but inulin treatment ameliorated inflammation in KO mice. Besides, inulin treatment repaired the intestinal epithelial barrier as evidenced by increased levels of intestinal TJ (tight junction) proteins [ZO-1 (zonula occludens-1) and occluding] in KO mice. Moreover, serum levels of uremic toxins, including IS (indoxyl sulfate) and PCS (p-cresol sulfate), were reduced in inulin-treated KO mice. Further investigation unveiled that inulin supplementation enhanced microbial diversity and raised the relative abundance of beneficial bacteria, involving SCFAs-producing bacteria (e.g., Akkermansia and Ruminococcus). Additionally, inulin treatment increased the production of gut microbiota-derived SCFAs (acetate, propionate and butyrate concentrations) in KO mice, which was positively correlated with the effectiveness of hyperuricemia relief.ConclusionsOur findings showed that inulin may be a promising therapeutic candidate for the treatment of hyperuricemia. Moreover, alleviation of hyperuricemia by inulin supplementation was, at least, partially conciliated by modulation of gut microbiota and its metabolites. More... »

PAGES

2217-2230

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-020-02414-x

DOI

http://dx.doi.org/10.1007/s00394-020-02414-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1132040710

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/33104864


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1111", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Nutrition and Dietetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dietary Supplements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Microbiome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hyperuricemia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.412521.1", 
          "name": [
            "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guo", 
        "givenName": "Yingjie", 
        "id": "sg:person.012041740203.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012041740203.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.412521.1", 
          "name": [
            "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yu", 
        "givenName": "Yanan", 
        "id": "sg:person.07350105251.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07350105251.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Metabolic Diseases, Qingdao University, 266003, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.410645.2", 
          "name": [
            "Institute of Metabolic Diseases, Qingdao University, 266003, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Hailong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.412521.1", 
          "name": [
            "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ding", 
        "givenName": "Xueli", 
        "id": "sg:person.01352520122.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352520122.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.412521.1", 
          "name": [
            "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xiaoyu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.412521.1", 
          "name": [
            "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jing", 
        "givenName": "Xue", 
        "id": "sg:person.0627114022.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627114022.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Synthetic Biology Technology Innovation Center of Shandong Province, 266101, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "BGI-Qingdao, BGI-Shenzhen, 266555, Qingdao, Shandong, China", 
            "Synthetic Biology Technology Innovation Center of Shandong Province, 266101, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Jianwei", 
        "id": "sg:person.01205576745.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205576745.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "BGI-Qingdao, BGI-Shenzhen, 266555, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.21155.32", 
          "name": [
            "BGI-Qingdao, BGI-Shenzhen, 266555, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Guilin", 
        "id": "sg:person.010153034162.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010153034162.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.412521.1", 
          "name": [
            "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Yuan", 
        "id": "sg:person.011553754031.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011553754031.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.412521.1", 
          "name": [
            "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jiang", 
        "givenName": "Chen", 
        "id": "sg:person.015625222603.76", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015625222603.76"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Metabolic Diseases, Qingdao University, 266003, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.410645.2", 
          "name": [
            "Institute of Metabolic Diseases, Qingdao University, 266003, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Zhen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Metabolic Diseases, Qingdao University, 266003, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.410645.2", 
          "name": [
            "Institute of Metabolic Diseases, Qingdao University, 266003, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "He", 
        "givenName": "Yuwei", 
        "id": "sg:person.011763651031.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011763651031.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Metabolic Diseases, Qingdao University, 266003, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.410645.2", 
          "name": [
            "Institute of Metabolic Diseases, Qingdao University, 266003, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Changgui", 
        "id": "sg:person.0676564741.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676564741.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China", 
          "id": "http://www.grid.ac/institutes/grid.412521.1", 
          "name": [
            "Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tian", 
        "givenName": "Zibin", 
        "id": "sg:person.01256542533.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256542533.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/s41584-020-0441-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1128481532", 
          "https://doi.org/10.1038/s41584-020-0441-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrgastro.2017.75", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086020795", 
          "https://doi.org/10.1038/nrgastro.2017.75"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11906-016-0684-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042984124", 
          "https://doi.org/10.1007/s11906-016-0684-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep20602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001228643", 
          "https://doi.org/10.1038/srep20602"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10157-020-01892-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1126654234", 
          "https://doi.org/10.1007/s10157-020-01892-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41396-019-0364-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1112057358", 
          "https://doi.org/10.1038/s41396-019-0364-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrgastro.2015.47", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022534311", 
          "https://doi.org/10.1038/nrgastro.2015.47"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ismej.2015.53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028996799", 
          "https://doi.org/10.1038/ismej.2015.53"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12020-018-1605-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103763122", 
          "https://doi.org/10.1007/s12020-018-1605-5"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-10-26", 
    "datePublishedReg": "2020-10-26", 
    "description": "PurposeInulin is a type of fermentable dietary fiber, which is non-digestible, and can improve metabolic function by modulating intestinal microbiota. This study aimed to evaluate the role of inulin in hyperuricemia and microbial composition of the gut microbiota in a mouse model of hyperuricemia established through knockout of Uox (urate oxidase) gene.MethodsKO (Uox-knockout) and WT (wild-type) mice were given inulin or saline by gavage for 7\u00a0weeks. The effect of inulin to combat hyperuricemia was determined by assessing the changes in serum UA (uric acid) levels, inflammatory parameters, epithelial barrier integrity, fecal microbiota alterations, and SCFA (short-chain fatty acid) concentrations in KO mice.ResultsInulin supplementation can effectively alleviate hyperuricemia, increase the expressions of ABCG2 in intestine, and downregulate expression and activity of hepatic XOD (xanthine oxidase) in KO mice. It was revealed that the levels of inflammatory cytokines and the LPS (lipopolysaccharide) were remarkably higher in the KO group than those in the WT group, indicating systemic inflammation of hyperuricemic mice, but inulin treatment ameliorated inflammation in KO mice. Besides, inulin treatment repaired the intestinal epithelial barrier as evidenced by increased levels of intestinal TJ (tight junction) proteins [ZO-1 (zonula occludens-1) and occluding] in KO mice. Moreover, serum levels of uremic toxins, including IS (indoxyl sulfate) and PCS (p-cresol sulfate), were reduced in inulin-treated KO mice. Further investigation unveiled that inulin supplementation enhanced microbial diversity and raised the relative abundance of beneficial bacteria, involving SCFAs-producing bacteria (e.g., Akkermansia and Ruminococcus). Additionally, inulin treatment increased the production of gut microbiota-derived SCFAs (acetate, propionate and butyrate concentrations) in KO mice, which was positively correlated with the effectiveness of hyperuricemia relief.ConclusionsOur findings showed that inulin may be a promising therapeutic candidate for the treatment of hyperuricemia. Moreover, alleviation of hyperuricemia by inulin supplementation was, at least, partially conciliated by modulation of gut microbiota and its metabolites.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00394-020-02414-x", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.8887053", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1294989", 
        "issn": [
          "1436-6207", 
          "1436-6215"
        ], 
        "name": "European Journal of Nutrition", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "60"
      }
    ], 
    "keywords": [
      "KO mice", 
      "inulin supplementation", 
      "inulin treatment", 
      "gut microbiota", 
      "fecal microbiota alterations", 
      "serum UA levels", 
      "SCFA-producing bacteria", 
      "intestinal TJ proteins", 
      "intestinal epithelial barrier", 
      "promising therapeutic candidate", 
      "expression of ABCG2", 
      "treatment of hyperuricemia", 
      "epithelial barrier integrity", 
      "fermentable dietary fiber", 
      "hepatic XOD", 
      "inflammatory parameters", 
      "systemic inflammation", 
      "hyperuricemic mice", 
      "serum levels", 
      "microbiota alterations", 
      "WT mice", 
      "UA levels", 
      "inflammatory cytokines", 
      "role of inulin", 
      "KO group", 
      "WT group", 
      "mouse model", 
      "uremic toxins", 
      "intestinal microbiota", 
      "hyperuricemia", 
      "barrier integrity", 
      "therapeutic candidate", 
      "epithelial barrier", 
      "SCFA concentrations", 
      "mice", 
      "ConclusionsOur findings", 
      "TJ proteins", 
      "supplementation", 
      "effects of inulin", 
      "microbiota", 
      "inflammation", 
      "treatment", 
      "dietary fiber", 
      "further investigation", 
      "metabolic functions", 
      "beneficial bacteria", 
      "microbial composition", 
      "inulin", 
      "gavage", 
      "group", 
      "levels", 
      "cytokines", 
      "expression", 
      "LPS", 
      "saline", 
      "weeks", 
      "intestine", 
      "ABCG2", 
      "SCFA", 
      "XOD", 
      "modulates", 
      "relief", 
      "alterations", 
      "toxin", 
      "knockout", 
      "metabolites", 
      "bacteria", 
      "findings", 
      "PCS", 
      "modulation", 
      "alleviation", 
      "activity", 
      "protein", 
      "study", 
      "genes", 
      "role", 
      "effect", 
      "changes", 
      "barriers", 
      "concentration", 
      "candidates", 
      "function", 
      "Uox gene", 
      "IS", 
      "relative abundance", 
      "microbial diversity", 
      "integrity", 
      "effectiveness", 
      "types", 
      "fibers", 
      "investigation", 
      "production", 
      "model", 
      "parameters", 
      "abundance", 
      "composition", 
      "diversity"
    ], 
    "name": "Inulin supplementation ameliorates hyperuricemia and modulates gut microbiota in Uox-knockout mice", 
    "pagination": "2217-2230", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1132040710"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00394-020-02414-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "33104864"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00394-020-02414-x", 
      "https://app.dimensions.ai/details/publication/pub.1132040710"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-11-24T21:06", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_845.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00394-020-02414-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00394-020-02414-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00394-020-02414-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00394-020-02414-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00394-020-02414-x'


 

This table displays all metadata directly associated to this object as RDF triples.

322 TRIPLES      21 PREDICATES      138 URIs      121 LITERALS      14 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00394-020-02414-x schema:about N1168b3ba7d824f94a5f95d22f6fc5697
2 N1a73d0f9d78f4aeb918feaa48a4ac78e
3 N6f9f4cc6bed24f9c8668eb633e2e29be
4 N8fe3044e94cc42879088c19c9b0c5c99
5 Na6963158fa554ec8bec9ee4de4d31f17
6 Nd5c361dfc67449f8a2affa816bf8d793
7 Nd87d267ea9384a0d8808f7b7159d7e22
8 anzsrc-for:11
9 anzsrc-for:1111
10 schema:author N5f4768b5aa8b45b598abffa73c629a77
11 schema:citation sg:pub.10.1007/s10157-020-01892-x
12 sg:pub.10.1007/s11906-016-0684-z
13 sg:pub.10.1007/s12020-018-1605-5
14 sg:pub.10.1038/ismej.2015.53
15 sg:pub.10.1038/nrgastro.2015.47
16 sg:pub.10.1038/nrgastro.2017.75
17 sg:pub.10.1038/s41396-019-0364-5
18 sg:pub.10.1038/s41584-020-0441-1
19 sg:pub.10.1038/srep20602
20 schema:datePublished 2020-10-26
21 schema:datePublishedReg 2020-10-26
22 schema:description PurposeInulin is a type of fermentable dietary fiber, which is non-digestible, and can improve metabolic function by modulating intestinal microbiota. This study aimed to evaluate the role of inulin in hyperuricemia and microbial composition of the gut microbiota in a mouse model of hyperuricemia established through knockout of Uox (urate oxidase) gene.MethodsKO (Uox-knockout) and WT (wild-type) mice were given inulin or saline by gavage for 7 weeks. The effect of inulin to combat hyperuricemia was determined by assessing the changes in serum UA (uric acid) levels, inflammatory parameters, epithelial barrier integrity, fecal microbiota alterations, and SCFA (short-chain fatty acid) concentrations in KO mice.ResultsInulin supplementation can effectively alleviate hyperuricemia, increase the expressions of ABCG2 in intestine, and downregulate expression and activity of hepatic XOD (xanthine oxidase) in KO mice. It was revealed that the levels of inflammatory cytokines and the LPS (lipopolysaccharide) were remarkably higher in the KO group than those in the WT group, indicating systemic inflammation of hyperuricemic mice, but inulin treatment ameliorated inflammation in KO mice. Besides, inulin treatment repaired the intestinal epithelial barrier as evidenced by increased levels of intestinal TJ (tight junction) proteins [ZO-1 (zonula occludens-1) and occluding] in KO mice. Moreover, serum levels of uremic toxins, including IS (indoxyl sulfate) and PCS (p-cresol sulfate), were reduced in inulin-treated KO mice. Further investigation unveiled that inulin supplementation enhanced microbial diversity and raised the relative abundance of beneficial bacteria, involving SCFAs-producing bacteria (e.g., Akkermansia and Ruminococcus). Additionally, inulin treatment increased the production of gut microbiota-derived SCFAs (acetate, propionate and butyrate concentrations) in KO mice, which was positively correlated with the effectiveness of hyperuricemia relief.ConclusionsOur findings showed that inulin may be a promising therapeutic candidate for the treatment of hyperuricemia. Moreover, alleviation of hyperuricemia by inulin supplementation was, at least, partially conciliated by modulation of gut microbiota and its metabolites.
23 schema:genre article
24 schema:isAccessibleForFree true
25 schema:isPartOf N2dd52e44074d49a199147b06ce7e8c35
26 N46ddd05810b643018ff5d7791a94988a
27 sg:journal.1294989
28 schema:keywords ABCG2
29 ConclusionsOur findings
30 IS
31 KO group
32 KO mice
33 LPS
34 PCS
35 SCFA
36 SCFA concentrations
37 SCFA-producing bacteria
38 TJ proteins
39 UA levels
40 Uox gene
41 WT group
42 WT mice
43 XOD
44 abundance
45 activity
46 alleviation
47 alterations
48 bacteria
49 barrier integrity
50 barriers
51 beneficial bacteria
52 candidates
53 changes
54 composition
55 concentration
56 cytokines
57 dietary fiber
58 diversity
59 effect
60 effectiveness
61 effects of inulin
62 epithelial barrier
63 epithelial barrier integrity
64 expression
65 expression of ABCG2
66 fecal microbiota alterations
67 fermentable dietary fiber
68 fibers
69 findings
70 function
71 further investigation
72 gavage
73 genes
74 group
75 gut microbiota
76 hepatic XOD
77 hyperuricemia
78 hyperuricemic mice
79 inflammation
80 inflammatory cytokines
81 inflammatory parameters
82 integrity
83 intestinal TJ proteins
84 intestinal epithelial barrier
85 intestinal microbiota
86 intestine
87 inulin
88 inulin supplementation
89 inulin treatment
90 investigation
91 knockout
92 levels
93 metabolic functions
94 metabolites
95 mice
96 microbial composition
97 microbial diversity
98 microbiota
99 microbiota alterations
100 model
101 modulates
102 modulation
103 mouse model
104 parameters
105 production
106 promising therapeutic candidate
107 protein
108 relative abundance
109 relief
110 role
111 role of inulin
112 saline
113 serum UA levels
114 serum levels
115 study
116 supplementation
117 systemic inflammation
118 therapeutic candidate
119 toxin
120 treatment
121 treatment of hyperuricemia
122 types
123 uremic toxins
124 weeks
125 schema:name Inulin supplementation ameliorates hyperuricemia and modulates gut microbiota in Uox-knockout mice
126 schema:pagination 2217-2230
127 schema:productId N13d308bb3331424ea8b8c4d6c4bc1a20
128 N6904736c9d68414796454bb1bba469bf
129 Nb4044204bada4c429910e3897883c4b3
130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1132040710
131 https://doi.org/10.1007/s00394-020-02414-x
132 schema:sdDatePublished 2022-11-24T21:06
133 schema:sdLicense https://scigraph.springernature.com/explorer/license/
134 schema:sdPublisher Nbb9569494e494716b4f6fa1b01ffddfb
135 schema:url https://doi.org/10.1007/s00394-020-02414-x
136 sgo:license sg:explorer/license/
137 sgo:sdDataset articles
138 rdf:type schema:ScholarlyArticle
139 N0217293e8a3042a494421f746ac0f5ba rdf:first sg:person.010153034162.54
140 rdf:rest N9d5b82f04f5a4d0994d4c947a68c767d
141 N026ad10d61e546a8b85d2816db6abeab rdf:first sg:person.01352520122.80
142 rdf:rest N4f1f777568b743c9b7f6e7911697c472
143 N1168b3ba7d824f94a5f95d22f6fc5697 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Dietary Supplements
145 rdf:type schema:DefinedTerm
146 N13a42f4dc4cf481da81f46546e046c69 rdf:first Ned3926cc04494b86afdafbd32353ee78
147 rdf:rest N026ad10d61e546a8b85d2816db6abeab
148 N13d308bb3331424ea8b8c4d6c4bc1a20 schema:name pubmed_id
149 schema:value 33104864
150 rdf:type schema:PropertyValue
151 N1a73d0f9d78f4aeb918feaa48a4ac78e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Hyperuricemia
153 rdf:type schema:DefinedTerm
154 N20fe86b84c804900bcd8930db369097b rdf:first sg:person.015625222603.76
155 rdf:rest N9badb985c4874f45a548504d4033c019
156 N2dd52e44074d49a199147b06ce7e8c35 schema:volumeNumber 60
157 rdf:type schema:PublicationVolume
158 N46ddd05810b643018ff5d7791a94988a schema:issueNumber 4
159 rdf:type schema:PublicationIssue
160 N4bf5c039fb7243b787aa00db5c8a5260 rdf:first sg:person.0676564741.16
161 rdf:rest Nc21724f6ae43499f8adb9360ce8b8c69
162 N4f1f777568b743c9b7f6e7911697c472 rdf:first N71a4c32383354377b13c81f3f582ca24
163 rdf:rest Naa6aab51a1254c3b811c860bf931d711
164 N55af3195dce14c21ae4639f43afa31f4 rdf:first sg:person.07350105251.28
165 rdf:rest N13a42f4dc4cf481da81f46546e046c69
166 N5f4768b5aa8b45b598abffa73c629a77 rdf:first sg:person.012041740203.60
167 rdf:rest N55af3195dce14c21ae4639f43afa31f4
168 N6904736c9d68414796454bb1bba469bf schema:name doi
169 schema:value 10.1007/s00394-020-02414-x
170 rdf:type schema:PropertyValue
171 N6f9f4cc6bed24f9c8668eb633e2e29be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Gastrointestinal Microbiome
173 rdf:type schema:DefinedTerm
174 N6fda84ffebb149299b6969418aa8a3e7 rdf:first sg:person.01205576745.01
175 rdf:rest N0217293e8a3042a494421f746ac0f5ba
176 N71a4c32383354377b13c81f3f582ca24 schema:affiliation grid-institutes:grid.412521.1
177 schema:familyName Li
178 schema:givenName Xiaoyu
179 rdf:type schema:Person
180 N8fe3044e94cc42879088c19c9b0c5c99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Mice
182 rdf:type schema:DefinedTerm
183 N9badb985c4874f45a548504d4033c019 rdf:first Ne250ce06d1a04eaca2a14bcf492fbda7
184 rdf:rest Naf36d4b635584d38ac75967f0e3fa801
185 N9d5b82f04f5a4d0994d4c947a68c767d rdf:first sg:person.011553754031.05
186 rdf:rest N20fe86b84c804900bcd8930db369097b
187 Na6963158fa554ec8bec9ee4de4d31f17 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Animals
189 rdf:type schema:DefinedTerm
190 Naa6aab51a1254c3b811c860bf931d711 rdf:first sg:person.0627114022.20
191 rdf:rest N6fda84ffebb149299b6969418aa8a3e7
192 Naf36d4b635584d38ac75967f0e3fa801 rdf:first sg:person.011763651031.40
193 rdf:rest N4bf5c039fb7243b787aa00db5c8a5260
194 Nb4044204bada4c429910e3897883c4b3 schema:name dimensions_id
195 schema:value pub.1132040710
196 rdf:type schema:PropertyValue
197 Nbb9569494e494716b4f6fa1b01ffddfb schema:name Springer Nature - SN SciGraph project
198 rdf:type schema:Organization
199 Nc21724f6ae43499f8adb9360ce8b8c69 rdf:first sg:person.01256542533.70
200 rdf:rest rdf:nil
201 Nd5c361dfc67449f8a2affa816bf8d793 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Inulin
203 rdf:type schema:DefinedTerm
204 Nd87d267ea9384a0d8808f7b7159d7e22 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Mice, Knockout
206 rdf:type schema:DefinedTerm
207 Ne250ce06d1a04eaca2a14bcf492fbda7 schema:affiliation grid-institutes:grid.410645.2
208 schema:familyName Liu
209 schema:givenName Zhen
210 rdf:type schema:Person
211 Ned3926cc04494b86afdafbd32353ee78 schema:affiliation grid-institutes:grid.410645.2
212 schema:familyName Li
213 schema:givenName Hailong
214 rdf:type schema:Person
215 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
216 schema:name Medical and Health Sciences
217 rdf:type schema:DefinedTerm
218 anzsrc-for:1111 schema:inDefinedTermSet anzsrc-for:
219 schema:name Nutrition and Dietetics
220 rdf:type schema:DefinedTerm
221 sg:grant.8887053 http://pending.schema.org/fundedItem sg:pub.10.1007/s00394-020-02414-x
222 rdf:type schema:MonetaryGrant
223 sg:journal.1294989 schema:issn 1436-6207
224 1436-6215
225 schema:name European Journal of Nutrition
226 schema:publisher Springer Nature
227 rdf:type schema:Periodical
228 sg:person.010153034162.54 schema:affiliation grid-institutes:grid.21155.32
229 schema:familyName Liu
230 schema:givenName Guilin
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010153034162.54
232 rdf:type schema:Person
233 sg:person.011553754031.05 schema:affiliation grid-institutes:grid.412521.1
234 schema:familyName Lin
235 schema:givenName Yuan
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011553754031.05
237 rdf:type schema:Person
238 sg:person.011763651031.40 schema:affiliation grid-institutes:grid.410645.2
239 schema:familyName He
240 schema:givenName Yuwei
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011763651031.40
242 rdf:type schema:Person
243 sg:person.012041740203.60 schema:affiliation grid-institutes:grid.412521.1
244 schema:familyName Guo
245 schema:givenName Yingjie
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012041740203.60
247 rdf:type schema:Person
248 sg:person.01205576745.01 schema:affiliation grid-institutes:None
249 schema:familyName Chen
250 schema:givenName Jianwei
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205576745.01
252 rdf:type schema:Person
253 sg:person.01256542533.70 schema:affiliation grid-institutes:grid.412521.1
254 schema:familyName Tian
255 schema:givenName Zibin
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256542533.70
257 rdf:type schema:Person
258 sg:person.01352520122.80 schema:affiliation grid-institutes:grid.412521.1
259 schema:familyName Ding
260 schema:givenName Xueli
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352520122.80
262 rdf:type schema:Person
263 sg:person.015625222603.76 schema:affiliation grid-institutes:grid.412521.1
264 schema:familyName Jiang
265 schema:givenName Chen
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015625222603.76
267 rdf:type schema:Person
268 sg:person.0627114022.20 schema:affiliation grid-institutes:grid.412521.1
269 schema:familyName Jing
270 schema:givenName Xue
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627114022.20
272 rdf:type schema:Person
273 sg:person.0676564741.16 schema:affiliation grid-institutes:grid.410645.2
274 schema:familyName Li
275 schema:givenName Changgui
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676564741.16
277 rdf:type schema:Person
278 sg:person.07350105251.28 schema:affiliation grid-institutes:grid.412521.1
279 schema:familyName Yu
280 schema:givenName Yanan
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07350105251.28
282 rdf:type schema:Person
283 sg:pub.10.1007/s10157-020-01892-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1126654234
284 https://doi.org/10.1007/s10157-020-01892-x
285 rdf:type schema:CreativeWork
286 sg:pub.10.1007/s11906-016-0684-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1042984124
287 https://doi.org/10.1007/s11906-016-0684-z
288 rdf:type schema:CreativeWork
289 sg:pub.10.1007/s12020-018-1605-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103763122
290 https://doi.org/10.1007/s12020-018-1605-5
291 rdf:type schema:CreativeWork
292 sg:pub.10.1038/ismej.2015.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028996799
293 https://doi.org/10.1038/ismej.2015.53
294 rdf:type schema:CreativeWork
295 sg:pub.10.1038/nrgastro.2015.47 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022534311
296 https://doi.org/10.1038/nrgastro.2015.47
297 rdf:type schema:CreativeWork
298 sg:pub.10.1038/nrgastro.2017.75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086020795
299 https://doi.org/10.1038/nrgastro.2017.75
300 rdf:type schema:CreativeWork
301 sg:pub.10.1038/s41396-019-0364-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112057358
302 https://doi.org/10.1038/s41396-019-0364-5
303 rdf:type schema:CreativeWork
304 sg:pub.10.1038/s41584-020-0441-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1128481532
305 https://doi.org/10.1038/s41584-020-0441-1
306 rdf:type schema:CreativeWork
307 sg:pub.10.1038/srep20602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001228643
308 https://doi.org/10.1038/srep20602
309 rdf:type schema:CreativeWork
310 grid-institutes:None schema:alternateName Synthetic Biology Technology Innovation Center of Shandong Province, 266101, Qingdao, Shandong, China
311 schema:name BGI-Qingdao, BGI-Shenzhen, 266555, Qingdao, Shandong, China
312 Synthetic Biology Technology Innovation Center of Shandong Province, 266101, Qingdao, Shandong, China
313 rdf:type schema:Organization
314 grid-institutes:grid.21155.32 schema:alternateName BGI-Qingdao, BGI-Shenzhen, 266555, Qingdao, Shandong, China
315 schema:name BGI-Qingdao, BGI-Shenzhen, 266555, Qingdao, Shandong, China
316 rdf:type schema:Organization
317 grid-institutes:grid.410645.2 schema:alternateName Institute of Metabolic Diseases, Qingdao University, 266003, Qingdao, Shandong, China
318 schema:name Institute of Metabolic Diseases, Qingdao University, 266003, Qingdao, Shandong, China
319 rdf:type schema:Organization
320 grid-institutes:grid.412521.1 schema:alternateName Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China
321 schema:name Department of Gastroenterology, The Affiliated Hospital of Qingdao University, 266000, Qingdao, Shandong, China
322 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...