Effect of vitamin D deficiency on depressive symptoms in child and adolescent psychiatric patients: results of a randomized controlled trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-02-27

AUTHORS

Lars Libuda, Nina Timmesfeld, Jochen Antel, Raphael Hirtz, Jens Bauer, Dagmar Führer, Denise Zwanziger, Dana Öztürk, Gina Langenbach, Denise Hahn, Stefanie Ring, Triinu Peters, Anke Hinney, Judith Bühlmeier, Johannes Hebebrand, Corinna Grasemann, Manuel Föcker

ABSTRACT

PurposeWhile observational studies revealed inverse associations between serum vitamin D levels [25(OH)D] and depression, randomized controlled trials (RCT) in children and adolescents are lacking. This RCT examined the effect of an untreated vitamin D deficiency compared to an immediate vitamin D3 supplementation on depression scores in children and adolescents during standard day and in-patient psychiatric treatment.MethodsPatients with vitamin D deficiency [25(OH)D ≤ 30 nmol/l] and at least mild depression [Beck Depression Inventory II (BDI-II) > 13] (n = 113) were 1:1 randomized into verum (VG; 2640 IU vitamin D3/d) or placebo group (PG) in a double-blind manner. During the intervention period of 28 days, both groups additionally received treatment as usual. BDI-II scores were assessed as primary outcome, DISYPS-II (Diagnostic System for Mental Disorders in Childhood and Adolescence, Self- and Parent Rating) and serum total 25(OH)D were secondary outcomes.ResultsAt admission, 49.3% of the screened patients (n = 280) had vitamin D deficiency. Although the intervention led to a higher increase of 25(OH)D levels in the VG than in the PG (treatment difference: + 14 ng/ml; 95% CI 4.86–23.77; p = 0.003), the change in BDI-II scores did not differ (+ 1.3; 95% CI − 2.22 to 4.81; p = 0.466). In contrast, DISYPS parental ratings revealed pronounced improvements of depressive symptoms in the VG (− 0.68; 95% CI − 1.23 to − 0.13; p = 0.016).ConclusionWhereas this study failed to show a vitamin D supplementation effect on self-rated depression in adolescent in- or daycare patients, parents reported less depressive symptoms in VG at the end of our study. Future trials should consider clinician-rated depressive symptoms as primary outcome.Trial registration“German Clinical Trials Register” (https://www.drks.de), registration number: DRKS00009758 More... »

PAGES

3415-3424

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-020-02176-6

DOI

http://dx.doi.org/10.1007/s00394-020-02176-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1125132334

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32108263


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