Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-11-20

AUTHORS

Elisabeth Lerchbaum, Christian Trummer, Verena Theiler-Schwetz, Martina Kollmann, Monika Wölfler, Annemieke C. Heijboer, Stefan Pilz, Barbara Obermayer-Pietsch

ABSTRACT

PurposeIt has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline.MethodsThe Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. One-hundred healthy men with serum TT levels < 10.4 nmol/l and 25-hydroxyvitamin D [25(OH)D] levels < 75 nmol/l participated in the trial. Subjects were randomized to receive 20,000 IU of vitamin D3/week (n = 50) or placebo (n = 50) for 12 weeks. Primary outcome was TT measured using mass spectrometry. Secondary outcomes were free testosterone, free androgen index, sex hormone-binding globulin, estradiol, follicle-stimulating hormone, luteinizing hormone, metabolic characteristics, and body composition.ResultsNinety-four men [mean age and 25(OH)D: 47 (± 12) years and 56.3 (± 18.3) nmol/l, respectively] completed the study. We found no significant treatment effect on serum TT or on the remaining secondary outcome variables.ConclusionVitamin D treatment had no effect on serum TT levels in middle-aged healthy men with low TT levels. More... »

PAGES

3135-3146

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-018-1858-z

DOI

http://dx.doi.org/10.1007/s00394-018-1858-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1110063202

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30460609


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