The role of the microbiome for human health: from basic science to clinical applications View Full Text


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Article Info

DATE

2018-05-10

AUTHORS

M. Hasan Mohajeri, Robert J. M. Brummer, Robert A. Rastall, Rinse K. Weersma, Hermie J. M. Harmsen, Marijke Faas, Manfred Eggersdorfer

ABSTRACT

The 2017 annual symposium organized by the University Medical Center Groningen in The Netherlands focused on the role of the gut microbiome in human health and disease. Experts from academia and industry examined interactions of prebiotics, probiotics, or vitamins with the gut microbiome in health and disease, the development of the microbiome in early-life and the role of the microbiome on the gut–brain axis. The gut microbiota changes dramatically during pregnancy and intrinsic factors (such as stress), in addition to extrinsic factors (such as diet, and drugs) influence the composition and activity of the gut microbiome throughout life. Microbial metabolites, e.g. short-chain fatty acids affect gut–brain signaling and the immune response. The gut microbiota has a regulatory role on anxiety, mood, cognition and pain which is exerted via the gut–brain axis. Ingestion of prebiotics or probiotics has been used to treat a range of conditions including constipation, allergic reactions and infections in infancy, and IBS. Fecal microbiota transplantation (FMT) highly effective for treating recurrent Clostridium difficile infections. The gut microbiome affects virtually all aspects of human health, but the degree of scientific evidence, the models and technologies and the understanding of mechanisms of action vary considerably from one benefit area to the other. For a clinical practice to be broadly accepted, the mode of action, the therapeutic window, and potential side effects need to thoroughly be investigated. This calls for further coordinated state-of-the art research to better understand and document the human gut microbiome’s effects on human health. More... »

PAGES

1-14

References to SciGraph publications

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  • 2016-12-07. Erratum: The prebiotic concept and human health: a changing landscape with riboflavin as a novel prebiotic candidate? in EUROPEAN JOURNAL OF CLINICAL NUTRITION
  • 2007-12-13. Universal risk factors for multifactorial diseases in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2012-06-12. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner in MOLECULAR PSYCHIATRY
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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s00394-018-1703-4

    DOI

    http://dx.doi.org/10.1007/s00394-018-1703-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1103924899

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29748817


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