Inter-individual variability in the production of flavan-3-ol colonic metabolites: preliminary elucidation of urinary metabotypes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-04-03

AUTHORS

Pedro Mena, Iziar A. Ludwig, Virginia B. Tomatis, Animesh Acharjee, Luca Calani, Alice Rosi, Furio Brighenti, Sumantra Ray, Julian L. Griffin, Les J. Bluck, Daniele Del Rio

ABSTRACT

PurposeThere is much information on the bioavailability of (poly)phenolic compounds following acute intake of various foods. However, there are only limited data on the effects of repeated and combined exposure to specific (poly)phenol food sources and the inter-individual variability in their bioavailability. This study evaluated the combined urinary excretion of (poly)phenols from green tea and coffee following daily consumption by healthy subjects in free-living conditions. The inter-individual variability in the production of phenolic metabolites was also investigated.MethodsEleven participants consumed both tablets of green tea and green coffee bean extracts daily for 8 weeks and 24-h urine was collected on five different occasions. The urinary profile of phenolic metabolites and a set of multivariate statistical tests were used to investigate the putative existence of characteristic metabotypes in the production of flavan-3-ol microbial metabolites.Results(Poly)phenolic compounds in the green tea and green coffee bean extracts were absorbed and excreted after simultaneous consumption, with green tea resulting in more inter-individual variability in urinary excretion of phenolic metabolites. Three metabotypes in the production of flavan-3-ol microbial metabolites were tentatively defined, characterized by the excretion of different amounts of trihydroxyphenyl-γ-valerolactones, dihydroxyphenyl-γ-valerolactones, and hydroxyphenylpropionic acids.ConclusionsThe selective production of microbiota-derived metabolites from flavan-3-ols and the putative existence of characteristic metabotypes in their production represent an important development in the study of the bioavailability of plant bioactives. These observations will contribute to better understand the health effects and individual differences associated with consumption of flavan-3-ols, arguably the main class of flavonoids in the human diet. More... »

PAGES

1529-1543

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-018-1683-4

DOI

http://dx.doi.org/10.1007/s00394-018-1683-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103154477

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29616322


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32 MethodsEleven participants
33 PurposeThere
34 acid
35 acute intake
36 amount
37 bean
38 bean extract
39 bioactives
40 bioavailability
41 characteristic metabotypes
42 class
43 coffee
44 coffee bean extract
45 coffee beans
46 colonic metabolites
47 combined exposure
48 compounds
49 conditions
50 consumption
51 consumption of flavan-3-ols
52 daily consumption
53 data
54 development
55 diet
56 differences
57 different amounts
58 different occasions
59 dihydroxyphenyl
60 effect
61 elucidation
62 excretion
63 existence
64 exposure
65 extracts
66 flavan-3-ol colonic metabolites
67 flavan-3-ol microbial metabolites
68 flavan-3-ols
69 flavonoids
70 food
71 food sources
72 free-living conditions
73 green coffee bean extract
74 green coffee beans
75 green tea
76 health effects
77 healthy subjects
78 human diet
79 hydroxyphenylpropionic acid
80 important developments
81 individual differences
82 information
83 intake
84 inter-individual variability
85 main classes
86 metabolites
87 metabotypes
88 microbial metabolites
89 microbiota-derived metabolites
90 more inter-individual variability
91 multivariate statistical tests
92 observations
93 occasions
94 participants
95 phenolic metabolites
96 plant bioactives
97 preliminary elucidation
98 production
99 profile
100 putative existence
101 selective production
102 set
103 simultaneous consumption
104 source
105 statistical tests
106 study
107 subjects
108 tablets
109 tea
110 test
111 trihydroxyphenyl
112 urinary excretion
113 urinary metabotypes
114 urinary profiles
115 urine
116 valerolactone
117 variability
118 weeks
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