Effects of vitamin D supplementation on FGF23: a randomized-controlled trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-30

AUTHORS

Christian Trummer, Verena Schwetz, Marlene Pandis, Martin R. Grübler, Nicolas Verheyen, Martin Gaksch, Armin Zittermann, Winfried März, Felix Aberer, Julia Steinkellner, Claudia Friedl, Vincent Brandenburg, Jakob Voelkl, Ioana Alesutan, Barbara Obermayer-Pietsch, Thomas R. Pieber, Andreas Tomaschitz, Stefan Pilz

ABSTRACT

PurposeFibroblast growth factor-23 (FGF23) is critical for phosphate homeostasis. Considering the high prevalence of vitamin D deficiency and the association of FGF23 with adverse outcomes, we investigated effects of vitamin D3 supplementation on FGF23 concentrations.MethodsThis is a post-hoc analysis of the Styrian Vitamin D Hypertension trial, a single-center, double-blind, randomized, placebo-controlled trial, conducted from 2011 to 2014 at the Medical University of Graz, Austria. Two hundred subjects with 25(OH)D concentrations < 30 ng/mL and arterial hypertension were randomized to receive either 2800 IU of vitamin D3 daily or placebo over 8 weeks. Primary outcome was the between-group difference in FGF23 levels at study end while adjusting for baseline values.ResultsOverall, 181 participants (mean ± standard deviation age, 60.1 ± 11.3; 48% women) with available c-term FGF23 concentrations were considered for the present analysis. Mean treatment duration was 54 ± 10 days in the vitamin D3 group and 54 ± 9 days in the placebo group. At baseline, FGF23 was significantly correlated with serum phosphate (r = 0.135; p = 0.002). Vitamin D3 supplementation had no significant effect on FGF23 in the entire cohort (mean treatment effect 0.374 pmol/L; 95% confidence interval − 0.024 to 0.772 pmol/L; p = 0.065), but increased FGF23 concentrations in subgroups with baseline 25(OH)D concentrations below 20 ng/mL (n = 70; mean treatment effect 0.973 pmol/L; 95% confidence interval − 0.032 to 1.979 pmol/L; p = 0.019) and 16 ng/mL (n = 40; mean treatment effect 0.593 pmol/L; 95% confidence interval 0.076 to 1.109; p = 0.022).ConclusionsVitamin D3 supplementation had no significant effect on FGF23 in the entire study cohort. We did, however, observe an increase of FGF23 concentrations in subgroups with low baseline 25(OH)D. More... »

PAGES

697-703

Journal

TITLE

European Journal of Nutrition

ISSUE

2

VOLUME

58

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-018-1672-7

DOI

http://dx.doi.org/10.1007/s00394-018-1672-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1101842288

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29602956


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    "description": "PurposeFibroblast growth factor-23 (FGF23) is critical for phosphate homeostasis. Considering the high prevalence of vitamin D deficiency and the association of FGF23 with adverse outcomes, we investigated effects of vitamin D3 supplementation on FGF23 concentrations.MethodsThis is a post-hoc analysis of the Styrian Vitamin D Hypertension trial, a single-center, double-blind, randomized, placebo-controlled trial, conducted from 2011 to 2014\u00a0at the Medical University of Graz, Austria. Two hundred subjects with 25(OH)D concentrations\u2009<\u200930\u00a0ng/mL and arterial hypertension were randomized to receive either 2800\u00a0IU of vitamin D3 daily or placebo over 8\u00a0weeks. Primary outcome was the between-group difference in FGF23 levels at study end while adjusting for baseline values.ResultsOverall, 181 participants (mean\u2009\u00b1\u2009standard deviation age, 60.1\u2009\u00b1\u200911.3; 48% women) with available c-term FGF23 concentrations were considered for the present analysis. Mean treatment duration was 54\u2009\u00b1\u200910 days in the vitamin D3 group and 54\u2009\u00b1\u20099 days in the placebo group. At baseline, FGF23 was significantly correlated with serum phosphate (r\u2009=\u20090.135; p\u2009=\u20090.002). Vitamin D3 supplementation had no significant effect on FGF23 in the entire cohort (mean treatment effect 0.374\u00a0pmol/L; 95% confidence interval \u2212\u20090.024 to 0.772\u00a0pmol/L; p\u2009=\u20090.065), but increased FGF23 concentrations in subgroups with baseline 25(OH)D concentrations below 20\u00a0ng/mL (n\u2009=\u200970; mean treatment effect 0.973\u00a0pmol/L; 95% confidence interval \u2212\u20090.032 to 1.979\u00a0pmol/L; p\u2009=\u20090.019) and 16\u00a0ng/mL (n\u2009=\u200940; mean treatment effect 0.593\u00a0pmol/L; 95% confidence interval 0.076 to 1.109; p\u2009=\u20090.022).ConclusionsVitamin D3 supplementation had no significant effect on FGF23 in the entire study cohort. We did, however, observe an increase of FGF23 concentrations in subgroups with low baseline 25(OH)D.", 
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344 schema:name Medizinische Klinik mit Schwerpunkt Kardiologie, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
345 rdf:type schema:Organization
 




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