Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects View Full Text


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Article Info

DATE

2017-02-16

AUTHORS

Martin Purpura, Ryan P. Lowery, Jacob M. Wilson, Haider Mannan, Gerald Münch, Valentina Razmovski-Naumovski

ABSTRACT

PURPOSE: The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO). METHODS: Twelve healthy human volunteers participated in a double-blinded, cross-over study. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-h period. RESULTS: CW8 showed the highest plasma concentrations of curcumin, demethoxycurcumin, and total curcuminoids, whereas CSL administration resulted in the highest levels of bisdemethoxycurcumin. CW8 (39-fold) showed significantly increased relative bioavailability of total curcuminoids (AUC0-12) in comparison with the unformulated StdC. CONCLUSION: The data presented suggest that γ-cyclodextrin curcumin formulation (CW8) significantly improves the absorption of curcuminoids in healthy humans. More... »

PAGES

929-938

References to SciGraph publications

  • 2015-09-03. Therapeutic Applications of Curcumin Nanoformulations in THE AAPS JOURNAL
  • 2012-09-26. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people in NUTRITION JOURNAL
  • 2007-01-09. “Spicing Up” of the Immune System by Curcumin in JOURNAL OF CLINICAL IMMUNOLOGY
  • 2014-01-24. Comparative absorption of curcumin formulations in NUTRITION JOURNAL
  • 2008-03-07. Curcumin: From ancient medicine to current clinical trials in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2007. ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF CURCUMIN in THE MOLECULAR TARGETS AND THERAPEUTIC USES OF CURCUMIN IN HEALTH AND DISEASE
  • 2006-03-17. Dose escalation of a curcuminoid formulation in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00394-016-1376-9

    DOI

    http://dx.doi.org/10.1007/s00394-016-1376-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083842651

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28204880


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