Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2017-02-16

AUTHORS

Martin Purpura, Ryan P. Lowery, Jacob M. Wilson, Haider Mannan, Gerald Münch, Valentina Razmovski-Naumovski

ABSTRACT

PURPOSE: The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO). METHODS: Twelve healthy human volunteers participated in a double-blinded, cross-over study. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-h period. RESULTS: CW8 showed the highest plasma concentrations of curcumin, demethoxycurcumin, and total curcuminoids, whereas CSL administration resulted in the highest levels of bisdemethoxycurcumin. CW8 (39-fold) showed significantly increased relative bioavailability of total curcuminoids (AUC0-12) in comparison with the unformulated StdC. CONCLUSION: The data presented suggest that γ-cyclodextrin curcumin formulation (CW8) significantly improves the absorption of curcuminoids in healthy humans. More... »

PAGES

929-938

References to SciGraph publications

  • 2015-09-03. Therapeutic Applications of Curcumin Nanoformulations in THE AAPS JOURNAL
  • 2012-09-26. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people in NUTRITION JOURNAL
  • 2007-01-09. “Spicing Up” of the Immune System by Curcumin in JOURNAL OF CLINICAL IMMUNOLOGY
  • 2014-01-24. Comparative absorption of curcumin formulations in NUTRITION JOURNAL
  • 2008-03-07. Curcumin: From ancient medicine to current clinical trials in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2007. ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF CURCUMIN in THE MOLECULAR TARGETS AND THERAPEUTIC USES OF CURCUMIN IN HEALTH AND DISEASE
  • 2006-03-17. Dose escalation of a curcuminoid formulation in BMC COMPLEMENTARY MEDICINE AND THERAPIES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00394-016-1376-9

    DOI

    http://dx.doi.org/10.1007/s00394-016-1376-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1083842651

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28204880


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Pharmacology and Pharmaceutical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents, Phytogenic", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antioxidants", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Area Under Curve", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cohort Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cross-Over Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Curcumin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Diarylheptanoids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dietary Supplements", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Double-Blind Method", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Food Additives", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Food Handling", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intestinal Absorption", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nutritive Value", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "gamma-Cyclodextrins", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Increnovo LLC, 2138 E Lafayette Pl, Milwaukee, WI 53202 USA", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Increnovo LLC, 2138 E Lafayette Pl, Milwaukee, WI 53202 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Purpura", 
            "givenName": "Martin", 
            "id": "sg:person.0647320012.70", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647320012.70"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL 33606 USA", 
              "id": "http://www.grid.ac/institutes/grid.267280.9", 
              "name": [
                "Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL 33606 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Lowery", 
            "givenName": "Ryan P.", 
            "id": "sg:person.01232762004.15", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232762004.15"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL 33606 USA", 
              "id": "http://www.grid.ac/institutes/grid.267280.9", 
              "name": [
                "Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL 33606 USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wilson", 
            "givenName": "Jacob M.", 
            "id": "sg:person.01164646604.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164646604.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre for Health Research, School of Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia", 
              "id": "http://www.grid.ac/institutes/grid.1029.a", 
              "name": [
                "Centre for Health Research, School of Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mannan", 
            "givenName": "Haider", 
            "id": "sg:person.01252334601.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252334601.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Molecular Medicine Research Group, School of Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia", 
              "id": "http://www.grid.ac/institutes/grid.1029.a", 
              "name": [
                "National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia", 
                "Molecular Medicine Research Group, School of Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "M\u00fcnch", 
            "givenName": "Gerald", 
            "id": "sg:person.01060325274.18", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060325274.18"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "South Western Sydney Clinical School, School of Medicine, The University of New South Wales, Sydney, NSW 2052 Australia", 
              "id": "http://www.grid.ac/institutes/grid.1005.4", 
              "name": [
                "National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia", 
                "South Western Sydney Clinical School, School of Medicine, The University of New South Wales, Sydney, NSW 2052 Australia"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Razmovski-Naumovski", 
            "givenName": "Valentina", 
            "id": "sg:person.01131674323.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131674323.12"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00018-008-7452-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017783394", 
              "https://doi.org/10.1007/s00018-008-7452-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1208/s12248-015-9811-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035545142", 
              "https://doi.org/10.1208/s12248-015-9811-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2891-13-11", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039872304", 
              "https://doi.org/10.1186/1475-2891-13-11"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-0-387-46401-5_3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022106134", 
              "https://doi.org/10.1007/978-0-387-46401-5_3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10875-006-9066-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050713395", 
              "https://doi.org/10.1007/s10875-006-9066-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1475-2891-11-79", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044803275", 
              "https://doi.org/10.1186/1475-2891-11-79"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1472-6882-6-10", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045578930", 
              "https://doi.org/10.1186/1472-6882-6-10"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-02-16", 
        "datePublishedReg": "2017-02-16", 
        "description": "PURPOSE: The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new \u03b3-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO).\nMETHODS: Twelve healthy human volunteers participated in a double-blinded, cross-over study. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-h period.\nRESULTS: CW8 showed the highest plasma concentrations of curcumin, demethoxycurcumin, and total curcuminoids, whereas CSL administration resulted in the highest levels of bisdemethoxycurcumin. CW8 (39-fold) showed significantly increased relative bioavailability of total curcuminoids (AUC0-12) in comparison with the unformulated StdC.\nCONCLUSION: The data presented suggest that \u03b3-cyclodextrin curcumin formulation (CW8) significantly improves the absorption of curcuminoids in healthy humans.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00394-016-1376-9", 
        "inLanguage": "en", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1294989", 
            "issn": [
              "1436-6207", 
              "1436-6215"
            ], 
            "name": "European Journal of Nutrition", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "3", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "57"
          }
        ], 
        "keywords": [
          "plasma concentrations", 
          "curcumin formulations", 
          "cross-over study", 
          "poor intestinal absorption", 
          "optimal health benefits", 
          "higher plasma concentrations", 
          "healthy human volunteers", 
          "relative oral bioavailability", 
          "total curcuminoids", 
          "formulation of curcumin", 
          "oral administration", 
          "intestinal absorption", 
          "healthy humans", 
          "phytosome formulation", 
          "human volunteers", 
          "oral bioavailability", 
          "relative bioavailability", 
          "health benefits", 
          "curcumin extract", 
          "human subjects", 
          "curcumin", 
          "administration", 
          "available formulations", 
          "bioavailability", 
          "Cw8", 
          "curcuminoids", 
          "individual curcuminoids", 
          "lipophilic compounds", 
          "high levels", 
          "molecular basis", 
          "baseline", 
          "volunteers", 
          "aqueous solubility", 
          "innovative formulation", 
          "study", 
          "turmeric", 
          "subjects", 
          "bisdemethoxycurcumin", 
          "demethoxycurcumin", 
          "humans", 
          "concentration", 
          "essential oil", 
          "intervals", 
          "extract", 
          "period", 
          "levels", 
          "benefits", 
          "absorption", 
          "data", 
          "rhizomes", 
          "comparison", 
          "analysis", 
          "formulation", 
          "low solubility", 
          "compounds", 
          "basis", 
          "cyclodextrin", 
          "complexes", 
          "solubility", 
          "oil", 
          "inclusion complexes", 
          "water", 
          "dispersibility", 
          "cyclodextrin curcumin formulation", 
          "standardized unformulated curcumin extract", 
          "unformulated curcumin extract", 
          "curcumin phytosome formulation", 
          "CSL administration", 
          "unformulated StdC.", 
          "StdC.", 
          "absorption of curcuminoids", 
          "different innovative formulations"
        ], 
        "name": "Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects", 
        "pagination": "929-938", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1083842651"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00394-016-1376-9"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28204880"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00394-016-1376-9", 
          "https://app.dimensions.ai/details/publication/pub.1083842651"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:44", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_726.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00394-016-1376-9"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00394-016-1376-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00394-016-1376-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00394-016-1376-9'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00394-016-1376-9'


     

    This table displays all metadata directly associated to this object as RDF triples.

    286 TRIPLES      22 PREDICATES      124 URIs      109 LITERALS      26 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00394-016-1376-9 schema:about N07b0a2db54c6489daf84118de5a27c90
    2 N15b1149b594344769958afe2a49ec6f5
    3 N18619acdf732463e82e158e9e724d30a
    4 N2ccbefcbec2f41f4a35ae50744189527
    5 N2ce90cbd14b249bf8823060ec518c91b
    6 N4d15cca19b7449bbb6ce0e0bda9e251b
    7 N582dd7ed252d4141bc5c977b45661e3d
    8 N62990c9b688246deb287894a337e36ef
    9 N63f1fe5900f443cf8662cdabd08dffd7
    10 N70ad4f392b004265978a4b472a109cbc
    11 N7b05f6cc9dd748b7965849f482ca38f5
    12 Na72a1a346d0e4640bfcb16104c18bed3
    13 Nb6c12a5f55e84404a99f65550445a938
    14 Nc77047574ec84a24bce3cd0bf7c35223
    15 Nc8a33cae35d74387802ce153eb440c92
    16 Nc8c2438d8eab43cf81c26003d9ee62ff
    17 Nef9b043e27a74280a07f42114e712cdc
    18 Nf07d94bed491469eac4838d4127cfdae
    19 Nffe7b16275e64978be54b2c97940a228
    20 anzsrc-for:11
    21 anzsrc-for:1115
    22 schema:author N47df6522f06745caa8dc2db7866bd35c
    23 schema:citation sg:pub.10.1007/978-0-387-46401-5_3
    24 sg:pub.10.1007/s00018-008-7452-4
    25 sg:pub.10.1007/s10875-006-9066-7
    26 sg:pub.10.1186/1472-6882-6-10
    27 sg:pub.10.1186/1475-2891-11-79
    28 sg:pub.10.1186/1475-2891-13-11
    29 sg:pub.10.1208/s12248-015-9811-z
    30 schema:datePublished 2017-02-16
    31 schema:datePublishedReg 2017-02-16
    32 schema:description PURPOSE: The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorption. In this study, we investigated the bioavailability of a new γ-cyclodextrin curcumin formulation (CW8). This formulation was compared to a standardized unformulated curcumin extract (StdC) and two commercially available formulations with purported increased bioavailability: a curcumin phytosome formulation (CSL) and a formulation of curcumin with essential oils of turmeric extracted from the rhizome (CEO). METHODS: Twelve healthy human volunteers participated in a double-blinded, cross-over study. The plasma concentrations of the individual curcuminoids that are present in turmeric (namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin) were determined at baseline and at various intervals after oral administration over a 12-h period. RESULTS: CW8 showed the highest plasma concentrations of curcumin, demethoxycurcumin, and total curcuminoids, whereas CSL administration resulted in the highest levels of bisdemethoxycurcumin. CW8 (39-fold) showed significantly increased relative bioavailability of total curcuminoids (AUC<sub>0-12</sub>) in comparison with the unformulated StdC. CONCLUSION: The data presented suggest that γ-cyclodextrin curcumin formulation (CW8) significantly improves the absorption of curcuminoids in healthy humans.
    33 schema:genre article
    34 schema:inLanguage en
    35 schema:isAccessibleForFree true
    36 schema:isPartOf N7f136faafb4b478395356ddeef0451e0
    37 Nd32a6128ce994b10a58e3a4ae82efc65
    38 sg:journal.1294989
    39 schema:keywords CSL administration
    40 Cw8
    41 StdC.
    42 absorption
    43 absorption of curcuminoids
    44 administration
    45 analysis
    46 aqueous solubility
    47 available formulations
    48 baseline
    49 basis
    50 benefits
    51 bioavailability
    52 bisdemethoxycurcumin
    53 comparison
    54 complexes
    55 compounds
    56 concentration
    57 cross-over study
    58 curcumin
    59 curcumin extract
    60 curcumin formulations
    61 curcumin phytosome formulation
    62 curcuminoids
    63 cyclodextrin
    64 cyclodextrin curcumin formulation
    65 data
    66 demethoxycurcumin
    67 different innovative formulations
    68 dispersibility
    69 essential oil
    70 extract
    71 formulation
    72 formulation of curcumin
    73 health benefits
    74 healthy human volunteers
    75 healthy humans
    76 high levels
    77 higher plasma concentrations
    78 human subjects
    79 human volunteers
    80 humans
    81 inclusion complexes
    82 individual curcuminoids
    83 innovative formulation
    84 intervals
    85 intestinal absorption
    86 levels
    87 lipophilic compounds
    88 low solubility
    89 molecular basis
    90 oil
    91 optimal health benefits
    92 oral administration
    93 oral bioavailability
    94 period
    95 phytosome formulation
    96 plasma concentrations
    97 poor intestinal absorption
    98 relative bioavailability
    99 relative oral bioavailability
    100 rhizomes
    101 solubility
    102 standardized unformulated curcumin extract
    103 study
    104 subjects
    105 total curcuminoids
    106 turmeric
    107 unformulated StdC.
    108 unformulated curcumin extract
    109 volunteers
    110 water
    111 schema:name Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects
    112 schema:pagination 929-938
    113 schema:productId N4a792f7dc3ed44f7a180dda5397c661c
    114 N60b243051d8e41f7a2f3d80dbf6f73c0
    115 Nf9fec838df0646caa3469dee8ca70991
    116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083842651
    117 https://doi.org/10.1007/s00394-016-1376-9
    118 schema:sdDatePublished 2022-01-01T18:44
    119 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    120 schema:sdPublisher N0f913a090fe5471388feb5801d814e64
    121 schema:url https://doi.org/10.1007/s00394-016-1376-9
    122 sgo:license sg:explorer/license/
    123 sgo:sdDataset articles
    124 rdf:type schema:ScholarlyArticle
    125 N07b0a2db54c6489daf84118de5a27c90 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name Food Handling
    127 rdf:type schema:DefinedTerm
    128 N0f913a090fe5471388feb5801d814e64 schema:name Springer Nature - SN SciGraph project
    129 rdf:type schema:Organization
    130 N15b1149b594344769958afe2a49ec6f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Young Adult
    132 rdf:type schema:DefinedTerm
    133 N18619acdf732463e82e158e9e724d30a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Male
    135 rdf:type schema:DefinedTerm
    136 N2ccbefcbec2f41f4a35ae50744189527 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Cross-Over Studies
    138 rdf:type schema:DefinedTerm
    139 N2ce90cbd14b249bf8823060ec518c91b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Dietary Supplements
    141 rdf:type schema:DefinedTerm
    142 N37a29662072e4cd1bb66dc4ccf3b39e6 rdf:first sg:person.01232762004.15
    143 rdf:rest N5214424d014e4601addb2a9eafe1bb7d
    144 N45f64da167e4464f8211325b23a69bee rdf:first sg:person.01252334601.04
    145 rdf:rest Nfed5a0aa115342259cb72c7570a96b48
    146 N47df6522f06745caa8dc2db7866bd35c rdf:first sg:person.0647320012.70
    147 rdf:rest N37a29662072e4cd1bb66dc4ccf3b39e6
    148 N4a792f7dc3ed44f7a180dda5397c661c schema:name doi
    149 schema:value 10.1007/s00394-016-1376-9
    150 rdf:type schema:PropertyValue
    151 N4d15cca19b7449bbb6ce0e0bda9e251b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Nutritive Value
    153 rdf:type schema:DefinedTerm
    154 N5214424d014e4601addb2a9eafe1bb7d rdf:first sg:person.01164646604.47
    155 rdf:rest N45f64da167e4464f8211325b23a69bee
    156 N582dd7ed252d4141bc5c977b45661e3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Antioxidants
    158 rdf:type schema:DefinedTerm
    159 N60b243051d8e41f7a2f3d80dbf6f73c0 schema:name pubmed_id
    160 schema:value 28204880
    161 rdf:type schema:PropertyValue
    162 N62990c9b688246deb287894a337e36ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    163 schema:name Food Additives
    164 rdf:type schema:DefinedTerm
    165 N63f1fe5900f443cf8662cdabd08dffd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    166 schema:name gamma-Cyclodextrins
    167 rdf:type schema:DefinedTerm
    168 N70ad4f392b004265978a4b472a109cbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    169 schema:name Cohort Studies
    170 rdf:type schema:DefinedTerm
    171 N74ff33f840854db8be678daa96fc3107 rdf:first sg:person.01131674323.12
    172 rdf:rest rdf:nil
    173 N7b05f6cc9dd748b7965849f482ca38f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    174 schema:name Curcumin
    175 rdf:type schema:DefinedTerm
    176 N7f136faafb4b478395356ddeef0451e0 schema:volumeNumber 57
    177 rdf:type schema:PublicationVolume
    178 Na72a1a346d0e4640bfcb16104c18bed3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Female
    180 rdf:type schema:DefinedTerm
    181 Nb6c12a5f55e84404a99f65550445a938 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Adult
    183 rdf:type schema:DefinedTerm
    184 Nc77047574ec84a24bce3cd0bf7c35223 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    185 schema:name Antineoplastic Agents, Phytogenic
    186 rdf:type schema:DefinedTerm
    187 Nc8a33cae35d74387802ce153eb440c92 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    188 schema:name Diarylheptanoids
    189 rdf:type schema:DefinedTerm
    190 Nc8c2438d8eab43cf81c26003d9ee62ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Intestinal Absorption
    192 rdf:type schema:DefinedTerm
    193 Nd32a6128ce994b10a58e3a4ae82efc65 schema:issueNumber 3
    194 rdf:type schema:PublicationIssue
    195 Nef9b043e27a74280a07f42114e712cdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    196 schema:name Humans
    197 rdf:type schema:DefinedTerm
    198 Nf07d94bed491469eac4838d4127cfdae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    199 schema:name Double-Blind Method
    200 rdf:type schema:DefinedTerm
    201 Nf9fec838df0646caa3469dee8ca70991 schema:name dimensions_id
    202 schema:value pub.1083842651
    203 rdf:type schema:PropertyValue
    204 Nfed5a0aa115342259cb72c7570a96b48 rdf:first sg:person.01060325274.18
    205 rdf:rest N74ff33f840854db8be678daa96fc3107
    206 Nffe7b16275e64978be54b2c97940a228 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Area Under Curve
    208 rdf:type schema:DefinedTerm
    209 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    210 schema:name Medical and Health Sciences
    211 rdf:type schema:DefinedTerm
    212 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
    213 schema:name Pharmacology and Pharmaceutical Sciences
    214 rdf:type schema:DefinedTerm
    215 sg:journal.1294989 schema:issn 1436-6207
    216 1436-6215
    217 schema:name European Journal of Nutrition
    218 schema:publisher Springer Nature
    219 rdf:type schema:Periodical
    220 sg:person.01060325274.18 schema:affiliation grid-institutes:grid.1029.a
    221 schema:familyName Münch
    222 schema:givenName Gerald
    223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060325274.18
    224 rdf:type schema:Person
    225 sg:person.01131674323.12 schema:affiliation grid-institutes:grid.1005.4
    226 schema:familyName Razmovski-Naumovski
    227 schema:givenName Valentina
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131674323.12
    229 rdf:type schema:Person
    230 sg:person.01164646604.47 schema:affiliation grid-institutes:grid.267280.9
    231 schema:familyName Wilson
    232 schema:givenName Jacob M.
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164646604.47
    234 rdf:type schema:Person
    235 sg:person.01232762004.15 schema:affiliation grid-institutes:grid.267280.9
    236 schema:familyName Lowery
    237 schema:givenName Ryan P.
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232762004.15
    239 rdf:type schema:Person
    240 sg:person.01252334601.04 schema:affiliation grid-institutes:grid.1029.a
    241 schema:familyName Mannan
    242 schema:givenName Haider
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252334601.04
    244 rdf:type schema:Person
    245 sg:person.0647320012.70 schema:affiliation grid-institutes:None
    246 schema:familyName Purpura
    247 schema:givenName Martin
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647320012.70
    249 rdf:type schema:Person
    250 sg:pub.10.1007/978-0-387-46401-5_3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022106134
    251 https://doi.org/10.1007/978-0-387-46401-5_3
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1007/s00018-008-7452-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017783394
    254 https://doi.org/10.1007/s00018-008-7452-4
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1007/s10875-006-9066-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050713395
    257 https://doi.org/10.1007/s10875-006-9066-7
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1186/1472-6882-6-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045578930
    260 https://doi.org/10.1186/1472-6882-6-10
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1186/1475-2891-11-79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044803275
    263 https://doi.org/10.1186/1475-2891-11-79
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1186/1475-2891-13-11 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039872304
    266 https://doi.org/10.1186/1475-2891-13-11
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1208/s12248-015-9811-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1035545142
    269 https://doi.org/10.1208/s12248-015-9811-z
    270 rdf:type schema:CreativeWork
    271 grid-institutes:None schema:alternateName Increnovo LLC, 2138 E Lafayette Pl, Milwaukee, WI 53202 USA
    272 schema:name Increnovo LLC, 2138 E Lafayette Pl, Milwaukee, WI 53202 USA
    273 rdf:type schema:Organization
    274 grid-institutes:grid.1005.4 schema:alternateName South Western Sydney Clinical School, School of Medicine, The University of New South Wales, Sydney, NSW 2052 Australia
    275 schema:name National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia
    276 South Western Sydney Clinical School, School of Medicine, The University of New South Wales, Sydney, NSW 2052 Australia
    277 rdf:type schema:Organization
    278 grid-institutes:grid.1029.a schema:alternateName Centre for Health Research, School of Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia
    279 Molecular Medicine Research Group, School of Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia
    280 schema:name Centre for Health Research, School of Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia
    281 Molecular Medicine Research Group, School of Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia
    282 National Institute of Complementary Medicine, Western Sydney University, Campbelltown, NSW 2560 Australia
    283 rdf:type schema:Organization
    284 grid-institutes:grid.267280.9 schema:alternateName Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL 33606 USA
    285 schema:name Department of Health Sciences and Human Performance, The University of Tampa, Tampa, FL 33606 USA
    286 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...