Fatty acid supply with complementary foods and LC-PUFA status in healthy infants: results of a randomised controlled trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-07-14

AUTHORS

Lars Libuda, Christina M. Mesch, Madlen Stimming, Hans Demmelmair, Berthold Koletzko, Petra Warschburger, Katharina Blanke, Eva Reischl, Hermann Kalhoff, Mathilde Kersting

ABSTRACT

Purpose Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breastfeeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) on term infant LC-PUFA status.Methods Healthy infants born at term were randomised to receive from the introduction of complementary feeding at the age of 4 to 6 months until age of 10 months ready-made complementary meals either with ALA-rich rapeseed oil (intervention group (IG)-R), with salmon twice weekly to provide preformed DHA (IG-F), or with linoleic acid-rich corn oil (control group, CG). Fatty acid composition was assessed in erythrocyte (RBC) and plasma glycerophospholipids.ResultsComplete data of fatty acids in RBC (plasma) were available from 158 (155) infants. After intervention, infants assigned to IG-F showed higher RBC and plasma percentages of eicosapentaenoic acid (EPA), DHA, and total n-3 LC-PUFA than CG (each p < 0.001). In IG-R, levels of ALA and the ratio of ALA to LA in plasma and RBC (all p < 0.0001) as well as RBC–EPA (p < 0.0001) were higher than in CG, while DHA levels did not differ between IG-R and CG.ConclusionsRegular fish consumption during complementary feeding enhances infant EPA and DHA status. The usage of rapeseed oil in small amounts concordant with EU-law for commercial meals enhances endogenic EPA-synthesis, but does not affect DHA status. Provision of oily fish with complementary feeds is advisable to prevent a decline of DHA status.Clinical Trial Registrationwww.clinicaltrials.gov, identifier: NCT01487889, title: Polyunsaturated fatty acids in child nutrition—a German multimodal optimisation study (PINGU). More... »

PAGES

1633-1644

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-015-0982-2

DOI

http://dx.doi.org/10.1007/s00394-015-0982-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052634951

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26169870


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36 schema:description Purpose Introduction of complementary food usually leads to decreasing intakes of long-chain n-3 polyunsaturated fatty acids (n-3 LC-PUFA), compared to full breastfeeding. In the randomised controlled PINGU intervention trial, we tested the effects of complementary foods with different contents of alpha-linolenic acid (ALA) and docosahexaenoic acid (DHA) on term infant LC-PUFA status.Methods Healthy infants born at term were randomised to receive from the introduction of complementary feeding at the age of 4 to 6 months until age of 10 months ready-made complementary meals either with ALA-rich rapeseed oil (intervention group (IG)-R), with salmon twice weekly to provide preformed DHA (IG-F), or with linoleic acid-rich corn oil (control group, CG). Fatty acid composition was assessed in erythrocyte (RBC) and plasma glycerophospholipids.ResultsComplete data of fatty acids in RBC (plasma) were available from 158 (155) infants. After intervention, infants assigned to IG-F showed higher RBC and plasma percentages of eicosapentaenoic acid (EPA), DHA, and total n-3 LC-PUFA than CG (each p < 0.001). In IG-R, levels of ALA and the ratio of ALA to LA in plasma and RBC (all p < 0.0001) as well as RBC–EPA (p < 0.0001) were higher than in CG, while DHA levels did not differ between IG-R and CG.ConclusionsRegular fish consumption during complementary feeding enhances infant EPA and DHA status. The usage of rapeseed oil in small amounts concordant with EU-law for commercial meals enhances endogenic EPA-synthesis, but does not affect DHA status. Provision of oily fish with complementary feeds is advisable to prevent a decline of DHA status.Clinical Trial Registrationwww.clinicaltrials.gov, identifier: NCT01487889, title: Polyunsaturated fatty acids in child nutrition—a German multimodal optimisation study (PINGU).
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54 acid
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63 complementary feeding
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76 eicosapentaenoic acid
77 erythrocytes
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