The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible ... View Full Text


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Article Info

DATE

2015-05-24

AUTHORS

K. A. T. Verheijden, L. E. M. Willemsen, S. Braber, T. Leusink-Muis, P. V. Jeurink, J. Garssen, A. D. Kraneveld, G. Folkerts

ABSTRACT

Purpose The incidence and severity of allergic asthma is rising, and novel strategies to prevent or treat this disease are needed. This study investigated the effects of different mixtures of non-digestible oligosaccharides combined with Bifidobacterium breve M-16V (BB) on the development of allergic airway inflammation in an animal model for house dust mite (HDM)-induced allergic asthma.MethodsBALB/c mice were sensitized intranasally (i.n.) with HDM and subsequently challenged (i.n.) with PBS or HDM while being fed diets containing different oligosaccharide mixtures in combination with BB or an isocaloric identical control diet. Bronchoalveolar lavage fluid (BALF) inflammatory cell influx, chemokine and cytokine concentrations in lung homogenates and supernatants of ex vivo HDM-restimulated lung cells were analyzed.ResultsThe HDM-induced influx of eosinophils and lymphocytes was reduced by the diet containing the short-chain and long-chain fructo-oligosaccharides and BB (FFBB). In addition to the HDM-induced cell influx, concentrations of IL-33, CCL17, CCL22, IL-6, IL-13 and IL-5 were increased in supernatants of lung homogenates or BALF and IL-4, IFN-γ and IL-10 were increased in restimulated lung cell suspensions of HDM-allergic mice. The diet containing FFBB reduced IL-6, IFN-γ, IL-4 and IL-10 concentrations, whereas the combination of galacto-oligosaccharides and long-chain fructo-oligosaccharides with BB was less potent in this model.ConclusionThese findings show that synbiotic dietary supplementation can affect respiratory allergic inflammation induced by HDM. The combination of FFBB was most effective in the prevention of HDM-induced airway inflammation in mice. More... »

PAGES

1141-1151

Journal

TITLE

European Journal of Nutrition

ISSUE

3

VOLUME

55

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00394-015-0928-8

    DOI

    http://dx.doi.org/10.1007/s00394-015-0928-8

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26003185


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    33 schema:description Purpose The incidence and severity of allergic asthma is rising, and novel strategies to prevent or treat this disease are needed. This study investigated the effects of different mixtures of non-digestible oligosaccharides combined with Bifidobacterium breve M-16V (BB) on the development of allergic airway inflammation in an animal model for house dust mite (HDM)-induced allergic asthma.MethodsBALB/c mice were sensitized intranasally (i.n.) with HDM and subsequently challenged (i.n.) with PBS or HDM while being fed diets containing different oligosaccharide mixtures in combination with BB or an isocaloric identical control diet. Bronchoalveolar lavage fluid (BALF) inflammatory cell influx, chemokine and cytokine concentrations in lung homogenates and supernatants of ex vivo HDM-restimulated lung cells were analyzed.ResultsThe HDM-induced influx of eosinophils and lymphocytes was reduced by the diet containing the short-chain and long-chain fructo-oligosaccharides and BB (FFBB). In addition to the HDM-induced cell influx, concentrations of IL-33, CCL17, CCL22, IL-6, IL-13 and IL-5 were increased in supernatants of lung homogenates or BALF and IL-4, IFN-γ and IL-10 were increased in restimulated lung cell suspensions of HDM-allergic mice. The diet containing FFBB reduced IL-6, IFN-γ, IL-4 and IL-10 concentrations, whereas the combination of galacto-oligosaccharides and long-chain fructo-oligosaccharides with BB was less potent in this model.ConclusionThese findings show that synbiotic dietary supplementation can affect respiratory allergic inflammation induced by HDM. The combination of FFBB was most effective in the prevention of HDM-induced airway inflammation in mice.
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    50 IL-33
    51 IL-4
    52 IL-5
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    55 MethodsBALB/c mice
    56 PBS
    57 addition
    58 airway inflammation
    59 allergic airway inflammation
    60 allergic asthma
    61 allergic inflammation
    62 animal models
    63 asthma
    64 asthma model
    65 c mice
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    80 effect
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    82 fed diets
    83 findings
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    87 incidence
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    92 lung cell suspensions
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    95 lymphocytes
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    100 non-digestible oligosaccharides
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    103 oligosaccharides
    104 prevention
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    107 severity
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