The development of allergic inflammation in a murine house dust mite asthma model is suppressed by synbiotic mixtures of non-digestible ... View Full Text


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Article Info

DATE

2015-05-24

AUTHORS

K. A. T. Verheijden, L. E. M. Willemsen, S. Braber, T. Leusink-Muis, P. V. Jeurink, J. Garssen, A. D. Kraneveld, G. Folkerts

ABSTRACT

Purpose The incidence and severity of allergic asthma is rising, and novel strategies to prevent or treat this disease are needed. This study investigated the effects of different mixtures of non-digestible oligosaccharides combined with Bifidobacterium breve M-16V (BB) on the development of allergic airway inflammation in an animal model for house dust mite (HDM)-induced allergic asthma.MethodsBALB/c mice were sensitized intranasally (i.n.) with HDM and subsequently challenged (i.n.) with PBS or HDM while being fed diets containing different oligosaccharide mixtures in combination with BB or an isocaloric identical control diet. Bronchoalveolar lavage fluid (BALF) inflammatory cell influx, chemokine and cytokine concentrations in lung homogenates and supernatants of ex vivo HDM-restimulated lung cells were analyzed.ResultsThe HDM-induced influx of eosinophils and lymphocytes was reduced by the diet containing the short-chain and long-chain fructo-oligosaccharides and BB (FFBB). In addition to the HDM-induced cell influx, concentrations of IL-33, CCL17, CCL22, IL-6, IL-13 and IL-5 were increased in supernatants of lung homogenates or BALF and IL-4, IFN-γ and IL-10 were increased in restimulated lung cell suspensions of HDM-allergic mice. The diet containing FFBB reduced IL-6, IFN-γ, IL-4 and IL-10 concentrations, whereas the combination of galacto-oligosaccharides and long-chain fructo-oligosaccharides with BB was less potent in this model.ConclusionThese findings show that synbiotic dietary supplementation can affect respiratory allergic inflammation induced by HDM. The combination of FFBB was most effective in the prevention of HDM-induced airway inflammation in mice. More... »

PAGES

1141-1151

Journal

TITLE

European Journal of Nutrition

ISSUE

3

VOLUME

55

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00394-015-0928-8

    DOI

    http://dx.doi.org/10.1007/s00394-015-0928-8

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26003185


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    33 schema:description Purpose The incidence and severity of allergic asthma is rising, and novel strategies to prevent or treat this disease are needed. This study investigated the effects of different mixtures of non-digestible oligosaccharides combined with Bifidobacterium breve M-16V (BB) on the development of allergic airway inflammation in an animal model for house dust mite (HDM)-induced allergic asthma.MethodsBALB/c mice were sensitized intranasally (i.n.) with HDM and subsequently challenged (i.n.) with PBS or HDM while being fed diets containing different oligosaccharide mixtures in combination with BB or an isocaloric identical control diet. Bronchoalveolar lavage fluid (BALF) inflammatory cell influx, chemokine and cytokine concentrations in lung homogenates and supernatants of ex vivo HDM-restimulated lung cells were analyzed.ResultsThe HDM-induced influx of eosinophils and lymphocytes was reduced by the diet containing the short-chain and long-chain fructo-oligosaccharides and BB (FFBB). In addition to the HDM-induced cell influx, concentrations of IL-33, CCL17, CCL22, IL-6, IL-13 and IL-5 were increased in supernatants of lung homogenates or BALF and IL-4, IFN-γ and IL-10 were increased in restimulated lung cell suspensions of HDM-allergic mice. The diet containing FFBB reduced IL-6, IFN-γ, IL-4 and IL-10 concentrations, whereas the combination of galacto-oligosaccharides and long-chain fructo-oligosaccharides with BB was less potent in this model.ConclusionThese findings show that synbiotic dietary supplementation can affect respiratory allergic inflammation induced by HDM. The combination of FFBB was most effective in the prevention of HDM-induced airway inflammation in mice.
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    40 Bifidobacterium breve M-16V
    41 CCL17
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    45 HDM-allergic mice
    46 IFN
    47 IL-10
    48 IL-10 concentrations
    49 IL-13
    50 IL-33
    51 IL-4
    52 IL-5
    53 IL-6
    54 M-16V
    55 MethodsBALB/c mice
    56 PBS
    57 addition
    58 airway inflammation
    59 allergic airway inflammation
    60 allergic asthma
    61 allergic inflammation
    62 animal models
    63 asthma
    64 asthma model
    65 c mice
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    67 cell suspensions
    68 cells
    69 chemokines
    70 combination
    71 concentration
    72 control diet
    73 cytokine concentrations
    74 development
    75 diet
    76 dietary supplementation
    77 different mixtures
    78 disease
    79 dust mite
    80 effect
    81 eosinophils
    82 fed diets
    83 findings
    84 homogenates
    85 house dust mite
    86 identical control diet
    87 incidence
    88 inflammation
    89 inflammatory cell influx
    90 influx
    91 influx of eosinophils
    92 lung cell suspensions
    93 lung cells
    94 lung homogenates
    95 lymphocytes
    96 mice
    97 mites
    98 mixture
    99 model
    100 non-digestible oligosaccharides
    101 novel strategy
    102 oligosaccharide mixtures
    103 oligosaccharides
    104 prevention
    105 purpose
    106 respiratory allergic inflammation
    107 severity
    108 strategies
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