Determinants of the transition from a cardiometabolic normal to abnormal overweight/obese phenotype in a Spanish population View Full Text


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Article Info

DATE

2013-12-10

AUTHORS

Helmut Schröder, Rafel Ramos, José M. Baena-Díez, Michelle A. Mendez, Dolors Juvinyà Canal, Montserrat Fíto, Joan Sala, Roberto Elosua

ABSTRACT

Purpose There is limited prospective evidence at population scale of the impacts of lifestyle and surrogate measures of general and abdominal adiposity on the transition of a metabolically healthy (absence of a metabolic disorder) overweight/obese (MHOO) phenotype to a metabolically abnormal overweight/obese (MAOO) phenotype. Therefore, we determined the relationship between 10-year body mass index (BMI), waist circumferences (WC), waist to height ratio (WHtR), and lifestyle changes and the transition of the MHOO phenotype.MethodsWe conducted a prospective population-based study of 3,052 male and female Spaniards aged 25–74 years who were followed from 2000 through 2009. Diet and leisure-time physical activity were recorded on validated questionnaires. Weight, height, WC, blood lipids, glycemia, and blood pressure were measured. All variables were obtained at baseline (BL) and follow-up (FL). Participants with a BMI ≥ 25 kg/m2 and free from hypercholesterolemia, hypertriglyceridemia, diabetes, hypertension, and low HDL and high LDL cholesterol levels were characterized as the MHOO phenotype. A composite healthy lifestyle index (HLI) was constructed by including temporary changes in 3 lifestyle variables (diet, leisure-time physical activity, and smoking).ResultsInitially, 20.8 % of subjects had the MHOO phenotype; 49.2 % of these shifted to MAOO phenotype. In multivariate analysis, changes in BMI, WC, WHtR were positively associated (p = 0.004, p = 0.018, and p = 0.016, respectively) with this transition. One unit increase in the HLI was associated with a 33 % lower risk (p = 0.025) to the MAOO phenotype transition after adjusting for age, sex, educational level, and baseline energy intake, BMI, WC, and WHtR.ConclusionsThe presence of metabolic disorders in the MHOO phenotype is predicted by an increase in anthropometric surrogate measures of general and abdominal adiposity. In contrast, a healthy lifestyle protects against a transition to the MAOO phenotype. More... »

PAGES

1345-1353

Journal

TITLE

European Journal of Nutrition

ISSUE

6

VOLUME

53

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-013-0635-2

DOI

http://dx.doi.org/10.1007/s00394-013-0635-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034181591

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24322835


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39 schema:description Purpose There is limited prospective evidence at population scale of the impacts of lifestyle and surrogate measures of general and abdominal adiposity on the transition of a metabolically healthy (absence of a metabolic disorder) overweight/obese (MHOO) phenotype to a metabolically abnormal overweight/obese (MAOO) phenotype. Therefore, we determined the relationship between 10-year body mass index (BMI), waist circumferences (WC), waist to height ratio (WHtR), and lifestyle changes and the transition of the MHOO phenotype.MethodsWe conducted a prospective population-based study of 3,052 male and female Spaniards aged 25–74 years who were followed from 2000 through 2009. Diet and leisure-time physical activity were recorded on validated questionnaires. Weight, height, WC, blood lipids, glycemia, and blood pressure were measured. All variables were obtained at baseline (BL) and follow-up (FL). Participants with a BMI ≥ 25 kg/m2 and free from hypercholesterolemia, hypertriglyceridemia, diabetes, hypertension, and low HDL and high LDL cholesterol levels were characterized as the MHOO phenotype. A composite healthy lifestyle index (HLI) was constructed by including temporary changes in 3 lifestyle variables (diet, leisure-time physical activity, and smoking).ResultsInitially, 20.8 % of subjects had the MHOO phenotype; 49.2 % of these shifted to MAOO phenotype. In multivariate analysis, changes in BMI, WC, WHtR were positively associated (p = 0.004, p = 0.018, and p = 0.016, respectively) with this transition. One unit increase in the HLI was associated with a 33 % lower risk (p = 0.025) to the MAOO phenotype transition after adjusting for age, sex, educational level, and baseline energy intake, BMI, WC, and WHtR.ConclusionsThe presence of metabolic disorders in the MHOO phenotype is predicted by an increase in anthropometric surrogate measures of general and abdominal adiposity. In contrast, a healthy lifestyle protects against a transition to the MAOO phenotype.
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46 schema:keywords ConclusionsThe presence
47 HDL
48 LDL cholesterol levels
49 MethodsWe
50 Spaniards
51 Spanish population
52 WHtR
53 WHtR.
54 abdominal adiposity
55 activity
56 adiposity
57 age
58 analysis
59 baseline
60 baseline energy intake
61 blood lipids
62 blood pressure
63 body mass index
64 changes
65 cholesterol levels
66 circumference
67 contrast
68 determinants
69 diabetes
70 diet
71 disorders
72 educational level
73 energy intake
74 evidence
75 glycemia
76 healthy lifestyle
77 healthy lifestyle index
78 healthy overweight/obese phenotype
79 height
80 high LDL cholesterol levels
81 hypercholesterolemia
82 hypertension
83 hypertriglyceridemia
84 impact
85 impact of lifestyle
86 increase
87 index
88 intake
89 leisure-time physical activity
90 levels
91 lifestyle
92 lifestyle changes
93 lifestyle index
94 lifestyle variables
95 lipids
96 low HDL
97 lower risk
98 m2
99 mass index
100 measures
101 metabolic disorders
102 multivariate analysis
103 obese phenotype
104 participants
105 phenotype
106 phenotype transition
107 physical activity
108 population
109 population scale
110 population-based study
111 presence
112 pressure
113 prospective evidence
114 prospective population-based study
115 purpose
116 questionnaire
117 ratio
118 relationship
119 risk
120 scale
121 sex
122 study
123 subjects
124 surrogate measure
125 temporary changes
126 transition
127 unit increase
128 variables
129 waist
130 waist circumference
131 weight
132 years
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