Determinants of the transition from a cardiometabolic normal to abnormal overweight/obese phenotype in a Spanish population View Full Text


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Article Info

DATE

2013-12-10

AUTHORS

Helmut Schröder, Rafel Ramos, José M. Baena-Díez, Michelle A. Mendez, Dolors Juvinyà Canal, Montserrat Fíto, Joan Sala, Roberto Elosua

ABSTRACT

Purpose There is limited prospective evidence at population scale of the impacts of lifestyle and surrogate measures of general and abdominal adiposity on the transition of a metabolically healthy (absence of a metabolic disorder) overweight/obese (MHOO) phenotype to a metabolically abnormal overweight/obese (MAOO) phenotype. Therefore, we determined the relationship between 10-year body mass index (BMI), waist circumferences (WC), waist to height ratio (WHtR), and lifestyle changes and the transition of the MHOO phenotype.MethodsWe conducted a prospective population-based study of 3,052 male and female Spaniards aged 25–74 years who were followed from 2000 through 2009. Diet and leisure-time physical activity were recorded on validated questionnaires. Weight, height, WC, blood lipids, glycemia, and blood pressure were measured. All variables were obtained at baseline (BL) and follow-up (FL). Participants with a BMI ≥ 25 kg/m2 and free from hypercholesterolemia, hypertriglyceridemia, diabetes, hypertension, and low HDL and high LDL cholesterol levels were characterized as the MHOO phenotype. A composite healthy lifestyle index (HLI) was constructed by including temporary changes in 3 lifestyle variables (diet, leisure-time physical activity, and smoking).ResultsInitially, 20.8 % of subjects had the MHOO phenotype; 49.2 % of these shifted to MAOO phenotype. In multivariate analysis, changes in BMI, WC, WHtR were positively associated (p = 0.004, p = 0.018, and p = 0.016, respectively) with this transition. One unit increase in the HLI was associated with a 33 % lower risk (p = 0.025) to the MAOO phenotype transition after adjusting for age, sex, educational level, and baseline energy intake, BMI, WC, and WHtR.ConclusionsThe presence of metabolic disorders in the MHOO phenotype is predicted by an increase in anthropometric surrogate measures of general and abdominal adiposity. In contrast, a healthy lifestyle protects against a transition to the MAOO phenotype. More... »

PAGES

1345-1353

Journal

TITLE

European Journal of Nutrition

ISSUE

6

VOLUME

53

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-013-0635-2

DOI

http://dx.doi.org/10.1007/s00394-013-0635-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034181591

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24322835


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39 schema:description Purpose There is limited prospective evidence at population scale of the impacts of lifestyle and surrogate measures of general and abdominal adiposity on the transition of a metabolically healthy (absence of a metabolic disorder) overweight/obese (MHOO) phenotype to a metabolically abnormal overweight/obese (MAOO) phenotype. Therefore, we determined the relationship between 10-year body mass index (BMI), waist circumferences (WC), waist to height ratio (WHtR), and lifestyle changes and the transition of the MHOO phenotype.MethodsWe conducted a prospective population-based study of 3,052 male and female Spaniards aged 25–74 years who were followed from 2000 through 2009. Diet and leisure-time physical activity were recorded on validated questionnaires. Weight, height, WC, blood lipids, glycemia, and blood pressure were measured. All variables were obtained at baseline (BL) and follow-up (FL). Participants with a BMI ≥ 25 kg/m2 and free from hypercholesterolemia, hypertriglyceridemia, diabetes, hypertension, and low HDL and high LDL cholesterol levels were characterized as the MHOO phenotype. A composite healthy lifestyle index (HLI) was constructed by including temporary changes in 3 lifestyle variables (diet, leisure-time physical activity, and smoking).ResultsInitially, 20.8 % of subjects had the MHOO phenotype; 49.2 % of these shifted to MAOO phenotype. In multivariate analysis, changes in BMI, WC, WHtR were positively associated (p = 0.004, p = 0.018, and p = 0.016, respectively) with this transition. One unit increase in the HLI was associated with a 33 % lower risk (p = 0.025) to the MAOO phenotype transition after adjusting for age, sex, educational level, and baseline energy intake, BMI, WC, and WHtR.ConclusionsThe presence of metabolic disorders in the MHOO phenotype is predicted by an increase in anthropometric surrogate measures of general and abdominal adiposity. In contrast, a healthy lifestyle protects against a transition to the MAOO phenotype.
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46 schema:keywords ConclusionsThe presence
47 HDL
48 LDL cholesterol levels
49 MAOO phenotype
50 MAOO phenotype transition
51 MHOO phenotype
52 MethodsWe
53 Spaniards
54 Spanish population
55 WHtR
56 WHtR.
57 abdominal adiposity
58 abnormal overweight/obese (MAOO) phenotype
59 activity
60 adiposity
61 age
62 analysis
63 anthropometric surrogate measures
64 baseline
65 baseline energy intake
66 blood lipids
67 blood pressure
68 body mass index
69 changes
70 cholesterol levels
71 circumference
72 composite healthy lifestyle index
73 contrast
74 determinants
75 diabetes
76 diet
77 disorders
78 educational level
79 energy intake
80 evidence
81 female Spaniards
82 glycemia
83 healthy lifestyle
84 healthy lifestyle index
85 healthy overweight/obese phenotype
86 height
87 high LDL cholesterol levels
88 hypercholesterolemia
89 hypertension
90 hypertriglyceridemia
91 impact
92 impact of lifestyle
93 increase
94 index
95 intake
96 leisure-time physical activity
97 levels
98 lifestyle
99 lifestyle changes
100 lifestyle index
101 lifestyle variables
102 lipids
103 low HDL
104 lower risk
105 m2
106 mass index
107 measures
108 metabolic disorders
109 multivariate analysis
110 obese phenotype
111 overweight/obese (MHOO) phenotype
112 participants
113 phenotype
114 phenotype transition
115 physical activity
116 population
117 population scale
118 population-based study
119 presence
120 pressure
121 prospective evidence
122 prospective population-based study
123 purpose
124 questionnaire
125 ratio
126 relationship
127 risk
128 scale
129 sex
130 study
131 subjects
132 surrogate measure
133 temporary changes
134 transition
135 unit increase
136 variables
137 waist
138 waist circumference
139 weight
140 years
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