High-dose cholecalciferol supplementation significantly increases peripheral CD4+ Tregs in healthy adults without negatively affecting the frequency of other immune cells View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-09-03

AUTHORS

Barbara Prietl, Gerlies Treiber, Julia K. Mader, Evelyne Hoeller, Michael Wolf, Stefan Pilz, Winfried B. Graninger, Barbara M. Obermayer-Pietsch, Thomas R. Pieber

ABSTRACT

BackgroundRegulatory T cells (Tregs) play a central role in the maintenance of self-tolerance. Animal and in vitro studies suggest that vitamin D is involved in reducing the risk of autoimmunity by modulating Tregs.MethodsIn a double-blind, placebo controlled study in 60 healthy volunteers, we assessed the effect of a 12-week high-dose oral cholecalciferol supplementation (140,000 IU/month) on the number and function of CD4posCD25highFoxP3posCD127dim Tregs. We also assessed the clinical safety of the supplementation and the effect on the frequency of other immune cells such as monocytes, dendritic cells, natural killer cells, natural killer T cells, B cells and subgroups of T cells. We also tested the in vitro effect of cholecalciferol on Tregs in human cell cultures.ResultsBy using FACS analysis, ex vivo suppressive co-cultures and apoptosis assays, we were able to show that a cholecalciferol supplementation leads to significantly increased numbers of peripheral Tregs in vivo. Tregs function and the frequency of other immune cells remained unchanged, and no clinically relevant safety concerns were found. The in vitro exposure of human peripheral blood mononuclear cells to cholecalciferol also supported our in vivo findings.ConclusionsOur results indicate a substantial effect of a supplementation with inactive vitamin D on the immune system of healthy humans in vivo and provide a rationale for future studies to investigate the immunomodulatory effects of vitamin D in autoimmune diseases. More... »

PAGES

751-759

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-013-0579-6

DOI

http://dx.doi.org/10.1007/s00394-013-0579-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029239372

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23999998


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61 cholecalciferol supplementation
62 clinical safety
63 concern
64 culture
65 dendritic cells
66 disease
67 effect
68 effect of cholecalciferol
69 ex vivo
70 exposure
71 findings
72 frequency
73 function
74 future studies
75 healthy adults
76 healthy humans
77 healthy volunteers
78 high-dose cholecalciferol supplementation
79 human cell cultures
80 human peripheral blood mononuclear cells
81 humans
82 immune cells
83 immune system
84 immunomodulatory effects
85 inactive vitamin D
86 killer T cells
87 killer cells
88 maintenance
89 monocytes
90 mononuclear cells
91 natural killer T cells
92 natural killer cells
93 number
94 oral cholecalciferol supplementation
95 peripheral CD4
96 peripheral Tregs
97 peripheral blood mononuclear cells
98 placebo
99 rationale
100 relevant safety concerns
101 results
102 risk
103 risk of autoimmunity
104 role
105 safety
106 safety concerns
107 study
108 subgroups
109 substantial effect
110 supplementation
111 system
112 vitamin D
113 vivo
114 vivo findings
115 volunteers
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