Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-12

AUTHORS

Wendy Atkinson, Pamela Downer, Michael Lever, Stephen T. Chambers, Peter M. George

ABSTRACT

BACKGROUND: Proline betaine (PB), a glycine betaine (GB) analogue found in citrus foods, increases urinary GB loss and plasma total homocysteine (tHcy) concentrations in rats. Its presence in human plasma is associated with increased GB excretion. AIM: To compare the effects of dietary levels of PB on GB excretion, and on plasma tHcy and GB concentrations in healthy volunteers. METHODS: In a randomized crossover study, eight healthy males (18-50 years) ingested either 750 mL orange juice (containing 0.545 g PB), a PB supplement (0.545 g PB dissolved in 750 mL apple juice), or 750 mL apple juice (control). Plasma PB, GB and tHcy, and urine PB, GB and creatinine concentrations were measured hourly for 6 h and at 24 h post-treatment. RESULTS: Plasma tHcy concentrations were not increased (relative to control) following ingestion of either orange juice or PB supplement. Both treatments produced a significant increase in plasma PB concentrations (P < 0.001), this effect being greater following orange juice compared with PB supplement (P < 0.05, 1-2 h). Urinary excretion of PB was greater than the control following both orange juice (P < 0.001) and PB supplement (P < 0.001), from 2 to 24 h post-treatment. This increase in PB excretion was significantly greater following orange juice compared with PB supplement with higher peak excretion (Cmax difference, P = 0.008). GB excretion was significantly greater following ingestion of orange juice compared with PB in apple juice (P = 0.007) and apple juice control (P < 0.001) in the first 2 h post-ingestion. CONCLUSIONS: PB administered in dietary doses had little effect on plasma tHcy concentrations in healthy humans. Ingestion of PB in orange juice compared with PB alone resulted in greater increases in the urinary excretion of PB and GB. More... »

PAGES

446-452

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-007-0684-5

DOI

http://dx.doi.org/10.1007/s00394-007-0684-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1028466390

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18060588


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Area Under Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Betaine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Beverages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Citrus sinensis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Over Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dietary Supplements", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Double-Blind Method", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homocysteine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Absorption", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kinetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proline", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Canterbury Health Laboratories", 
          "id": "https://www.grid.ac/institutes/grid.413344.5", 
          "name": [
            "Clinical Biochemistry Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Atkinson", 
        "givenName": "Wendy", 
        "id": "sg:person.01063550203.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063550203.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canterbury Health Laboratories", 
          "id": "https://www.grid.ac/institutes/grid.413344.5", 
          "name": [
            "Clinical Biochemistry Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Downer", 
        "givenName": "Pamela", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canterbury Health Laboratories", 
          "id": "https://www.grid.ac/institutes/grid.413344.5", 
          "name": [
            "Clinical Biochemistry Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lever", 
        "givenName": "Michael", 
        "id": "sg:person.01136574074.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136574074.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Otago", 
          "id": "https://www.grid.ac/institutes/grid.29980.3a", 
          "name": [
            "Pathology Dept., Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chambers", 
        "givenName": "Stephen T.", 
        "id": "sg:person.01330040355.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330040355.25"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Canterbury Health Laboratories", 
          "id": "https://www.grid.ac/institutes/grid.413344.5", 
          "name": [
            "Clinical Biochemistry Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch, New Zealand"
          ], 
          "type": "Organization"
        }, 
        "familyName": "George", 
        "givenName": "Peter M.", 
        "id": "sg:person.01025103615.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025103615.02"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1139/o96-030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001736830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0168-8227(98)00115-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002332182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0955-2863(98)00025-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012169388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000114569.54976.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013499184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000114569.54976.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013499184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.0000114569.54976.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013499184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.aca.2005.10.060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015197681"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2001.013395", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016646055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinbiochem.2003.11.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018308962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jfca.2004.05.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018867445"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(94)90165-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022997332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-4165(94)90165-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022997332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinbiochem.2007.03.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023283659"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci112878", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023985746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0308-8146(03)00063-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025146832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0308-8146(03)00063-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025146832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biocel.2003.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029404840"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clinbiochem.2007.05.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029662557"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejme068060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030558816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ab.2004.03.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041293656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(94)90090-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047355898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(94)90090-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047355898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048015291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chroma.2005.11.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049638273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.metabol.2004.07.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052810599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bse.2005.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053548677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bse.2005.01.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053548677"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.52.5.663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062813643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.52.5.663", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062813643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/136.6.1493", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077241470"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.21273/jashs.122.1.8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1111865976"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-12", 
    "datePublishedReg": "2007-12-01", 
    "description": "BACKGROUND: Proline betaine (PB), a glycine betaine (GB) analogue found in citrus foods, increases urinary GB loss and plasma total homocysteine (tHcy) concentrations in rats. Its presence in human plasma is associated with increased GB excretion.\nAIM: To compare the effects of dietary levels of PB on GB excretion, and on plasma tHcy and GB concentrations in healthy volunteers.\nMETHODS: In a randomized crossover study, eight healthy males (18-50 years) ingested either 750 mL orange juice (containing 0.545 g PB), a PB supplement (0.545 g PB dissolved in 750 mL apple juice), or 750 mL apple juice (control). Plasma PB, GB and tHcy, and urine PB, GB and creatinine concentrations were measured hourly for 6 h and at 24 h post-treatment.\nRESULTS: Plasma tHcy concentrations were not increased (relative to control) following ingestion of either orange juice or PB supplement. Both treatments produced a significant increase in plasma PB concentrations (P < 0.001), this effect being greater following orange juice compared with PB supplement (P < 0.05, 1-2 h). Urinary excretion of PB was greater than the control following both orange juice (P < 0.001) and PB supplement (P < 0.001), from 2 to 24 h post-treatment. This increase in PB excretion was significantly greater following orange juice compared with PB supplement with higher peak excretion (Cmax difference, P = 0.008). GB excretion was significantly greater following ingestion of orange juice compared with PB in apple juice (P = 0.007) and apple juice control (P < 0.001) in the first 2 h post-ingestion.\nCONCLUSIONS: PB administered in dietary doses had little effect on plasma tHcy concentrations in healthy humans. Ingestion of PB in orange juice compared with PB alone resulted in greater increases in the urinary excretion of PB and GB.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00394-007-0684-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1294989", 
        "issn": [
          "1436-6207", 
          "1435-1293"
        ], 
        "name": "European Journal of Nutrition", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "46"
      }
    ], 
    "name": "Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects", 
    "pagination": "446-452", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "879b2d6a1e1170936f27acc76c89306d93df68997c4883bdde9dcdac00431cf8"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18060588"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100888704"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00394-007-0684-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1028466390"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00394-007-0684-5", 
      "https://app.dimensions.ai/details/publication/pub.1028466390"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13102_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00394-007-0684-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00394-007-0684-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00394-007-0684-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00394-007-0684-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00394-007-0684-5'


 

This table displays all metadata directly associated to this object as RDF triples.

239 TRIPLES      21 PREDICATES      70 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00394-007-0684-5 schema:about N04ce6b23e84c498e8ee8cc915d55f299
2 N1edad072575b459cbb83b8ea5b2aa584
3 N2215304d44784431a7af948cae25d739
4 N39a974417932466f9ca98bc943604fb1
5 N4251b6fabeb8458d924411602b16b96d
6 N5431dd7ec66f4bbdba08095b8f28cd9a
7 N637ba3b0f0c740f7b251e85561070985
8 N6bb6d0af6dc94979ad0810899191521c
9 N6e87d7a9919749938bf57aa301761a03
10 N85e19c1dbf71455ca7b09c64d9c516d8
11 Na312e038d5214715b93436bfb688838c
12 Na5834d979e214841ae904ff49034864b
13 Na60d254572e6453094e50612b06b6099
14 Nbfd07b727aec4ecd98c5d74de476d623
15 Nce8102379f6c4c7d86f362db14a0cd5d
16 Ne82b0a24ad0b4b62bb34de3a754d5d9b
17 Nfb510f6b227045f2acbce627c7263130
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author Nc672f66bb3b9409098d68c5360d44a90
21 schema:citation https://doi.org/10.1002/jcp.20872
22 https://doi.org/10.1016/0009-8981(94)90090-6
23 https://doi.org/10.1016/0304-4165(94)90165-1
24 https://doi.org/10.1016/j.ab.2004.03.069
25 https://doi.org/10.1016/j.aca.2005.10.060
26 https://doi.org/10.1016/j.biocel.2003.10.001
27 https://doi.org/10.1016/j.bse.2005.01.005
28 https://doi.org/10.1016/j.chroma.2005.11.123
29 https://doi.org/10.1016/j.clinbiochem.2003.11.004
30 https://doi.org/10.1016/j.clinbiochem.2007.03.009
31 https://doi.org/10.1016/j.clinbiochem.2007.05.021
32 https://doi.org/10.1016/j.jfca.2004.05.004
33 https://doi.org/10.1016/j.metabol.2004.07.007
34 https://doi.org/10.1016/s0168-8227(98)00115-6
35 https://doi.org/10.1016/s0308-8146(03)00063-3
36 https://doi.org/10.1016/s0955-2863(98)00025-4
37 https://doi.org/10.1056/nejme068060
38 https://doi.org/10.1093/jn/136.6.1493
39 https://doi.org/10.1113/jphysiol.2001.013395
40 https://doi.org/10.1136/gut.52.5.663
41 https://doi.org/10.1139/o96-030
42 https://doi.org/10.1161/01.atv.0000114569.54976.31
43 https://doi.org/10.1172/jci112878
44 https://doi.org/10.21273/jashs.122.1.8
45 schema:datePublished 2007-12
46 schema:datePublishedReg 2007-12-01
47 schema:description BACKGROUND: Proline betaine (PB), a glycine betaine (GB) analogue found in citrus foods, increases urinary GB loss and plasma total homocysteine (tHcy) concentrations in rats. Its presence in human plasma is associated with increased GB excretion. AIM: To compare the effects of dietary levels of PB on GB excretion, and on plasma tHcy and GB concentrations in healthy volunteers. METHODS: In a randomized crossover study, eight healthy males (18-50 years) ingested either 750 mL orange juice (containing 0.545 g PB), a PB supplement (0.545 g PB dissolved in 750 mL apple juice), or 750 mL apple juice (control). Plasma PB, GB and tHcy, and urine PB, GB and creatinine concentrations were measured hourly for 6 h and at 24 h post-treatment. RESULTS: Plasma tHcy concentrations were not increased (relative to control) following ingestion of either orange juice or PB supplement. Both treatments produced a significant increase in plasma PB concentrations (P < 0.001), this effect being greater following orange juice compared with PB supplement (P < 0.05, 1-2 h). Urinary excretion of PB was greater than the control following both orange juice (P < 0.001) and PB supplement (P < 0.001), from 2 to 24 h post-treatment. This increase in PB excretion was significantly greater following orange juice compared with PB supplement with higher peak excretion (Cmax difference, P = 0.008). GB excretion was significantly greater following ingestion of orange juice compared with PB in apple juice (P = 0.007) and apple juice control (P < 0.001) in the first 2 h post-ingestion. CONCLUSIONS: PB administered in dietary doses had little effect on plasma tHcy concentrations in healthy humans. Ingestion of PB in orange juice compared with PB alone resulted in greater increases in the urinary excretion of PB and GB.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree false
51 schema:isPartOf N9e7783e46e5d4cab8582b2db3d40362f
52 Nf18e098a11104d97ad0706677def05a1
53 sg:journal.1294989
54 schema:name Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthy male subjects
55 schema:pagination 446-452
56 schema:productId N1fca055f43d24f9ebdf98d9f9d739618
57 N48ea575c4bb1492fa4b6c832277fb257
58 N812f806179234d84a2b85ec2eae0ff8f
59 N92b673b84c684ca4b54253aa41af14e6
60 N93ff0d49a42247799265479296aacfe6
61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028466390
62 https://doi.org/10.1007/s00394-007-0684-5
63 schema:sdDatePublished 2019-04-11T14:32
64 schema:sdLicense https://scigraph.springernature.com/explorer/license/
65 schema:sdPublisher Nbfd0c6c3d34e4e2fa8eea0ce53b97fa1
66 schema:url http://link.springer.com/10.1007%2Fs00394-007-0684-5
67 sgo:license sg:explorer/license/
68 sgo:sdDataset articles
69 rdf:type schema:ScholarlyArticle
70 N04ce6b23e84c498e8ee8cc915d55f299 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
71 schema:name Proline
72 rdf:type schema:DefinedTerm
73 N1edad072575b459cbb83b8ea5b2aa584 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Dietary Supplements
75 rdf:type schema:DefinedTerm
76 N1fca055f43d24f9ebdf98d9f9d739618 schema:name doi
77 schema:value 10.1007/s00394-007-0684-5
78 rdf:type schema:PropertyValue
79 N2215304d44784431a7af948cae25d739 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Middle Aged
81 rdf:type schema:DefinedTerm
82 N39a974417932466f9ca98bc943604fb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Betaine
84 rdf:type schema:DefinedTerm
85 N4251b6fabeb8458d924411602b16b96d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Area Under Curve
87 rdf:type schema:DefinedTerm
88 N48ea575c4bb1492fa4b6c832277fb257 schema:name dimensions_id
89 schema:value pub.1028466390
90 rdf:type schema:PropertyValue
91 N5431dd7ec66f4bbdba08095b8f28cd9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Double-Blind Method
93 rdf:type schema:DefinedTerm
94 N62ecd59292cd48539e770161323a89fa rdf:first sg:person.01330040355.25
95 rdf:rest Ne78b4a51b11747849bbf11c6eafc4aa5
96 N637ba3b0f0c740f7b251e85561070985 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Humans
98 rdf:type schema:DefinedTerm
99 N6bb6d0af6dc94979ad0810899191521c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Administration, Oral
101 rdf:type schema:DefinedTerm
102 N6e87d7a9919749938bf57aa301761a03 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Beverages
104 rdf:type schema:DefinedTerm
105 N812f806179234d84a2b85ec2eae0ff8f schema:name nlm_unique_id
106 schema:value 100888704
107 rdf:type schema:PropertyValue
108 N85e19c1dbf71455ca7b09c64d9c516d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cross-Over Studies
110 rdf:type schema:DefinedTerm
111 N8aed198a5666465dac4c903fdcc7d1ba rdf:first sg:person.01136574074.44
112 rdf:rest N62ecd59292cd48539e770161323a89fa
113 N8bac2579a4f9404fbaa5d40f3f693a17 rdf:first Ne98ba297dc9f45eeb1c80440bfb74e85
114 rdf:rest N8aed198a5666465dac4c903fdcc7d1ba
115 N92b673b84c684ca4b54253aa41af14e6 schema:name readcube_id
116 schema:value 879b2d6a1e1170936f27acc76c89306d93df68997c4883bdde9dcdac00431cf8
117 rdf:type schema:PropertyValue
118 N93ff0d49a42247799265479296aacfe6 schema:name pubmed_id
119 schema:value 18060588
120 rdf:type schema:PropertyValue
121 N9e7783e46e5d4cab8582b2db3d40362f schema:issueNumber 8
122 rdf:type schema:PublicationIssue
123 Na312e038d5214715b93436bfb688838c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Male
125 rdf:type schema:DefinedTerm
126 Na5834d979e214841ae904ff49034864b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Adolescent
128 rdf:type schema:DefinedTerm
129 Na60d254572e6453094e50612b06b6099 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Homocysteine
131 rdf:type schema:DefinedTerm
132 Nbfd07b727aec4ecd98c5d74de476d623 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Kinetics
134 rdf:type schema:DefinedTerm
135 Nbfd0c6c3d34e4e2fa8eea0ce53b97fa1 schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 Nc672f66bb3b9409098d68c5360d44a90 rdf:first sg:person.01063550203.98
138 rdf:rest N8bac2579a4f9404fbaa5d40f3f693a17
139 Nce8102379f6c4c7d86f362db14a0cd5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Citrus sinensis
141 rdf:type schema:DefinedTerm
142 Ne78b4a51b11747849bbf11c6eafc4aa5 rdf:first sg:person.01025103615.02
143 rdf:rest rdf:nil
144 Ne82b0a24ad0b4b62bb34de3a754d5d9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Adult
146 rdf:type schema:DefinedTerm
147 Ne98ba297dc9f45eeb1c80440bfb74e85 schema:affiliation https://www.grid.ac/institutes/grid.413344.5
148 schema:familyName Downer
149 schema:givenName Pamela
150 rdf:type schema:Person
151 Nf18e098a11104d97ad0706677def05a1 schema:volumeNumber 46
152 rdf:type schema:PublicationVolume
153 Nfb510f6b227045f2acbce627c7263130 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Intestinal Absorption
155 rdf:type schema:DefinedTerm
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
160 schema:name Clinical Sciences
161 rdf:type schema:DefinedTerm
162 sg:journal.1294989 schema:issn 1435-1293
163 1436-6207
164 schema:name European Journal of Nutrition
165 rdf:type schema:Periodical
166 sg:person.01025103615.02 schema:affiliation https://www.grid.ac/institutes/grid.413344.5
167 schema:familyName George
168 schema:givenName Peter M.
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025103615.02
170 rdf:type schema:Person
171 sg:person.01063550203.98 schema:affiliation https://www.grid.ac/institutes/grid.413344.5
172 schema:familyName Atkinson
173 schema:givenName Wendy
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063550203.98
175 rdf:type schema:Person
176 sg:person.01136574074.44 schema:affiliation https://www.grid.ac/institutes/grid.413344.5
177 schema:familyName Lever
178 schema:givenName Michael
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01136574074.44
180 rdf:type schema:Person
181 sg:person.01330040355.25 schema:affiliation https://www.grid.ac/institutes/grid.29980.3a
182 schema:familyName Chambers
183 schema:givenName Stephen T.
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01330040355.25
185 rdf:type schema:Person
186 https://doi.org/10.1002/jcp.20872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048015291
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/0009-8981(94)90090-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047355898
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/0304-4165(94)90165-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022997332
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.ab.2004.03.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041293656
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.aca.2005.10.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015197681
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/j.biocel.2003.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029404840
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.bse.2005.01.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053548677
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.chroma.2005.11.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049638273
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1016/j.clinbiochem.2003.11.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018308962
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/j.clinbiochem.2007.03.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023283659
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.clinbiochem.2007.05.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029662557
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.jfca.2004.05.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018867445
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.metabol.2004.07.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052810599
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/s0168-8227(98)00115-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002332182
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/s0308-8146(03)00063-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025146832
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/s0955-2863(98)00025-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012169388
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1056/nejme068060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030558816
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1093/jn/136.6.1493 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077241470
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1113/jphysiol.2001.013395 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016646055
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1136/gut.52.5.663 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062813643
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1139/o96-030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001736830
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1161/01.atv.0000114569.54976.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013499184
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1172/jci112878 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023985746
231 rdf:type schema:CreativeWork
232 https://doi.org/10.21273/jashs.122.1.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1111865976
233 rdf:type schema:CreativeWork
234 https://www.grid.ac/institutes/grid.29980.3a schema:alternateName University of Otago
235 schema:name Pathology Dept., Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
236 rdf:type schema:Organization
237 https://www.grid.ac/institutes/grid.413344.5 schema:alternateName Canterbury Health Laboratories
238 schema:name Clinical Biochemistry Unit, Canterbury Health Laboratories, P.O. Box 151, Christchurch, New Zealand
239 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...