Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-02

AUTHORS

Dae Young Kwon, Jin Sun Jang, Sang Mee Hong, Ji Eun Lee, So Ra Sung, Hye Ryeo Park, Sunmin Park

ABSTRACT

BACKGROUND: We previously reported that Chungkookjang (CKJ), fermented unsalted soybeans, exhibited better anti-diabetic action than cooked soybeans (CSB) in vitro, but its effectiveness and mechanism have not been studied in vivo. AIM OF THE STUDY: We investigated whether CKJ modulated insulin resistance, insulin secretion, and pancreatic beta-cell growth and survival in 90% pancreatectomized (Px) diabetic rats. METHODS: The Px rats weighing 201 +/- 12 g were divided into four groups and fed for 8 weeks with a CSB diet, a CKJ diet, a casein diet, or a casein diet plus rosiglitazone (20 mg/kg body weight/day). With the exception of protein sources and contents of isoflavonoid aglycones and glycosides, the composition of the diets was made identical by adding soybean oil and cellulose to a casein diet. At the end of the experimental periods, hyperglycemic clamp was performed in conscious, unstressed and overnight fasted Px rats to measure insulin secretion capacity. Insulin/IGF-1 signaling was measured by immunoblotting in isolated islets from the treated rats, and beta-cell mass, proliferation and apoptosis were also determined by immunohistochemistry. RESULTS: After 8-week administration, CSB did not modulate glucose-stimulated insulin secretion, but surprisingly, CKJ enhanced insulin secretion. In addition, CKJ potentiated insulin/IGF-1 signaling in islets via the induction of insulin receptor substrate-2 expression, leading to increasing pancreatic duodenal homeobox-1, insulin promoter transcription factor. In parallel with the enhancement of the signaling, CKJ elevated pancreatic beta-cell hyperplasia by increasing its proliferation and decreasing apoptosis, whereas CSB did not. CONCLUSION: Based on these results, the fermentation of soybeans predominantly with Bacillus subtilis generated isoflavonoid aglycones and small peptides, which improved insulinotropic action in islets of type 2 diabetic rats. Overall, the anti-diabetic action of CKJ was superior to CSB in type 2 diabetic rats. More... »

PAGES

44-52

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-006-0630-y

DOI

http://dx.doi.org/10.1007/s00394-006-0630-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1017180523

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17200876


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Area Under Curve", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Glucose", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dexamethasone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fermentation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glucose Clamp Technique", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypoglycemic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Resistance", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin Secretion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Insulin-Secreting Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pancreatectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Random Allocation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Soy Foods", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Soybeans", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Food Functional Research Division, Korean Food Research Institutes, Seoul, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwon", 
        "givenName": "Dae Young", 
        "id": "sg:person.01355405676.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355405676.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jang", 
        "givenName": "Jin Sun", 
        "id": "sg:person.01362714013.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362714013.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hong", 
        "givenName": "Sang Mee", 
        "id": "sg:person.013610615374.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013610615374.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lee", 
        "givenName": "Ji Eun", 
        "id": "sg:person.01246646361.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246646361.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sung", 
        "givenName": "So Ra", 
        "id": "sg:person.07356627512.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07356627512.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Hye Ryeo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Park", 
        "givenName": "Sunmin", 
        "id": "sg:person.01060641224.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060641224.70"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1023/a:1006806722619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003203012", 
          "https://doi.org/10.1023/a:1006806722619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.3.686", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005587952"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.55.01.06.db05-0648", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009863994"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diacare.26.3.791", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018151237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.55.04.06.db05-1089", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021793432"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci21845", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024860834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m508307200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028354034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m508307200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028354034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-003-1190-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030245545", 
          "https://doi.org/10.1007/s00125-003-1190-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-003-1190-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030245545", 
          "https://doi.org/10.1007/s00125-003-1190-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.suppl_3.s16", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031925582"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1753-4887.2005.tb00141.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033567744"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/biof.5520260403", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033655527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-1573(199911)13:7<601::aid-ptr550>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033844386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1099-1573(199911)13:7<601::aid-ptr550>3.0.co;2-o", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033844386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-002-1009-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035282322", 
          "https://doi.org/10.1007/s00125-002-1009-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00125-002-1009-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035282322", 
          "https://doi.org/10.1007/s00125-002-1009-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118387", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036376393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.metabol.2005.06.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041204976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci18581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043442132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.51.6.1825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044120088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.10187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044682613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1263/jbb.100.685", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044814601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/372182a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046415369", 
          "https://doi.org/10.1038/372182a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1079/bjn2002720", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046514481"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/diabetes.53.2.441", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046903081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci22217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047716662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.10.3434", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050840325"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.1097103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051045522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/biof.5520260101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053168417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2004-1653", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247278"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/76.6.1191", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075195874"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jn/107.7.1340", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082934972"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcn/68.6.1492s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083359977"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-02", 
    "datePublishedReg": "2007-02-01", 
    "description": "BACKGROUND: We previously reported that Chungkookjang (CKJ), fermented unsalted soybeans, exhibited better anti-diabetic action than cooked soybeans (CSB) in vitro, but its effectiveness and mechanism have not been studied in vivo.\nAIM OF THE STUDY: We investigated whether CKJ modulated insulin resistance, insulin secretion, and pancreatic beta-cell growth and survival in 90% pancreatectomized (Px) diabetic rats.\nMETHODS: The Px rats weighing 201 +/- 12 g were divided into four groups and fed for 8 weeks with a CSB diet, a CKJ diet, a casein diet, or a casein diet plus rosiglitazone (20 mg/kg body weight/day). With the exception of protein sources and contents of isoflavonoid aglycones and glycosides, the composition of the diets was made identical by adding soybean oil and cellulose to a casein diet. At the end of the experimental periods, hyperglycemic clamp was performed in conscious, unstressed and overnight fasted Px rats to measure insulin secretion capacity. Insulin/IGF-1 signaling was measured by immunoblotting in isolated islets from the treated rats, and beta-cell mass, proliferation and apoptosis were also determined by immunohistochemistry.\nRESULTS: After 8-week administration, CSB did not modulate glucose-stimulated insulin secretion, but surprisingly, CKJ enhanced insulin secretion. In addition, CKJ potentiated insulin/IGF-1 signaling in islets via the induction of insulin receptor substrate-2 expression, leading to increasing pancreatic duodenal homeobox-1, insulin promoter transcription factor. In parallel with the enhancement of the signaling, CKJ elevated pancreatic beta-cell hyperplasia by increasing its proliferation and decreasing apoptosis, whereas CSB did not.\nCONCLUSION: Based on these results, the fermentation of soybeans predominantly with Bacillus subtilis generated isoflavonoid aglycones and small peptides, which improved insulinotropic action in islets of type 2 diabetic rats. Overall, the anti-diabetic action of CKJ was superior to CSB in type 2 diabetic rats.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00394-006-0630-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1294989", 
        "issn": [
          "1436-6207", 
          "1435-1293"
        ], 
        "name": "European Journal of Nutrition", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "46"
      }
    ], 
    "name": "Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats", 
    "pagination": "44-52", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "51dac539e203f55137f7f0f8a34ebc1bfe6429198a662fd383645350fcffde2d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17200876"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100888704"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00394-006-0630-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1017180523"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00394-006-0630-y", 
      "https://app.dimensions.ai/details/publication/pub.1017180523"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13087_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00394-006-0630-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00394-006-0630-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00394-006-0630-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00394-006-0630-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00394-006-0630-y'


 

This table displays all metadata directly associated to this object as RDF triples.

311 TRIPLES      21 PREDICATES      83 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00394-006-0630-y schema:about N077cf28206c74e53b55f8f48de9ba184
2 N126753c131a74ca7a4af61718c49efd7
3 N18428def3f5c478d90acf0c52d56b7ea
4 N1a99ce30d91c4ef48f187002851ff607
5 N214d42f0a1a9436dab767f0549c26d12
6 N300f2930725d47a7bd1d78015151d022
7 N4eb014ac4b76496a9206eccecc4bbcba
8 N5770bab83e224043a5aa33d9f2a00a06
9 N585c0e9b1a0b497a9e4d895d68a3cf72
10 N60b808e78c80432ca7e29a5e31d03d0a
11 N7618b5607fe746bea75a8e796ac3efc7
12 N853011fab4ed4b028e49522804b9a669
13 N8f137e45a6874088a9e61d7a97ef733d
14 N9f95606ed5e843dd85e45bb9dfaa905f
15 Nb55b43eed67240afad4b95ef738ebaa2
16 Nb8de530e0add471d8f5268290aa613f1
17 Nbf69eb5e155a4971823101d6d8909a0d
18 Nc7a667a806564eb89280191397dd2b09
19 Nc952e5e944924b23b510125c4080f96e
20 Ncfd621872d204fc99a7e27349e5dd239
21 Nd8cd3adc4a0342319798723d9c9a6b21
22 Ne5226c92b66842d288e64bfb9b998240
23 Nf0661397621c4d35acfb75c5c78d1a52
24 Nf37a2efe10df4f1dbfd240085b53d183
25 anzsrc-for:11
26 anzsrc-for:1103
27 schema:author N93279ae06e1646a2954f106310e953c8
28 schema:citation sg:pub.10.1007/s00125-002-1009-0
29 sg:pub.10.1007/s00125-003-1190-9
30 sg:pub.10.1023/a:1006806722619
31 sg:pub.10.1038/372182a0
32 https://doi.org/10.1002/(sici)1099-1573(199911)13:7<601::aid-ptr550>3.0.co;2-o
33 https://doi.org/10.1002/biof.5520260101
34 https://doi.org/10.1002/biof.5520260403
35 https://doi.org/10.1002/jcp.10187
36 https://doi.org/10.1016/j.metabol.2005.06.021
37 https://doi.org/10.1073/pnas.84.10.3434
38 https://doi.org/10.1074/jbc.m508307200
39 https://doi.org/10.1079/bjn2002720
40 https://doi.org/10.1093/ajcn/68.6.1492s
41 https://doi.org/10.1093/ajcn/76.6.1191
42 https://doi.org/10.1093/jn/107.7.1340
43 https://doi.org/10.1101/gad.1097103
44 https://doi.org/10.1111/j.1753-4887.2005.tb00141.x
45 https://doi.org/10.1172/jci118387
46 https://doi.org/10.1172/jci18581
47 https://doi.org/10.1172/jci21845
48 https://doi.org/10.1172/jci22217
49 https://doi.org/10.1210/en.2004-1653
50 https://doi.org/10.1263/jbb.100.685
51 https://doi.org/10.2337/diabetes.51.3.686
52 https://doi.org/10.2337/diabetes.51.6.1825
53 https://doi.org/10.2337/diabetes.53.2.441
54 https://doi.org/10.2337/diabetes.53.suppl_3.s16
55 https://doi.org/10.2337/diabetes.55.01.06.db05-0648
56 https://doi.org/10.2337/diabetes.55.04.06.db05-1089
57 https://doi.org/10.2337/diacare.26.3.791
58 schema:datePublished 2007-02
59 schema:datePublishedReg 2007-02-01
60 schema:description BACKGROUND: We previously reported that Chungkookjang (CKJ), fermented unsalted soybeans, exhibited better anti-diabetic action than cooked soybeans (CSB) in vitro, but its effectiveness and mechanism have not been studied in vivo. AIM OF THE STUDY: We investigated whether CKJ modulated insulin resistance, insulin secretion, and pancreatic beta-cell growth and survival in 90% pancreatectomized (Px) diabetic rats. METHODS: The Px rats weighing 201 +/- 12 g were divided into four groups and fed for 8 weeks with a CSB diet, a CKJ diet, a casein diet, or a casein diet plus rosiglitazone (20 mg/kg body weight/day). With the exception of protein sources and contents of isoflavonoid aglycones and glycosides, the composition of the diets was made identical by adding soybean oil and cellulose to a casein diet. At the end of the experimental periods, hyperglycemic clamp was performed in conscious, unstressed and overnight fasted Px rats to measure insulin secretion capacity. Insulin/IGF-1 signaling was measured by immunoblotting in isolated islets from the treated rats, and beta-cell mass, proliferation and apoptosis were also determined by immunohistochemistry. RESULTS: After 8-week administration, CSB did not modulate glucose-stimulated insulin secretion, but surprisingly, CKJ enhanced insulin secretion. In addition, CKJ potentiated insulin/IGF-1 signaling in islets via the induction of insulin receptor substrate-2 expression, leading to increasing pancreatic duodenal homeobox-1, insulin promoter transcription factor. In parallel with the enhancement of the signaling, CKJ elevated pancreatic beta-cell hyperplasia by increasing its proliferation and decreasing apoptosis, whereas CSB did not. CONCLUSION: Based on these results, the fermentation of soybeans predominantly with Bacillus subtilis generated isoflavonoid aglycones and small peptides, which improved insulinotropic action in islets of type 2 diabetic rats. Overall, the anti-diabetic action of CKJ was superior to CSB in type 2 diabetic rats.
61 schema:genre research_article
62 schema:inLanguage en
63 schema:isAccessibleForFree false
64 schema:isPartOf N7c5e6f0c14b5494788f2137ee6049cff
65 Na6df6b69a6a745d1988eacdda3a395cb
66 sg:journal.1294989
67 schema:name Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats
68 schema:pagination 44-52
69 schema:productId N6b7b50d92f1940a4a8c4a8bcc4605596
70 Nbdeb449f62334eecb311f670ecb11cfb
71 Ndb23a0c432d44c74b18e121dd7a5890b
72 Nf87dde5f97a442a1945c4392c3e5dcde
73 Nf99df8fd95194a5282af1b25e2e78635
74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017180523
75 https://doi.org/10.1007/s00394-006-0630-y
76 schema:sdDatePublished 2019-04-11T14:29
77 schema:sdLicense https://scigraph.springernature.com/explorer/license/
78 schema:sdPublisher N6d947e7776d94ad3839d9bcf556a5289
79 schema:url http://link.springer.com/10.1007%2Fs00394-006-0630-y
80 sgo:license sg:explorer/license/
81 sgo:sdDataset articles
82 rdf:type schema:ScholarlyArticle
83 N077cf28206c74e53b55f8f48de9ba184 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Insulin
85 rdf:type schema:DefinedTerm
86 N126753c131a74ca7a4af61718c49efd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Insulin Resistance
88 rdf:type schema:DefinedTerm
89 N163ee3ca9053486cb86a62afad8362f7 schema:name Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea
90 rdf:type schema:Organization
91 N18428def3f5c478d90acf0c52d56b7ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Animals
93 rdf:type schema:DefinedTerm
94 N1a99ce30d91c4ef48f187002851ff607 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Fermentation
96 rdf:type schema:DefinedTerm
97 N214d42f0a1a9436dab767f0549c26d12 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Area Under Curve
99 rdf:type schema:DefinedTerm
100 N300f2930725d47a7bd1d78015151d022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Diabetes Mellitus
102 rdf:type schema:DefinedTerm
103 N436a2b76978141628524cbb107e501e2 rdf:first sg:person.013610615374.90
104 rdf:rest Na9c5a0b292d34d9d8663079e0a64cf10
105 N47461ce383fc43efa03881e9f4cd87ad schema:affiliation Nc8568d3b394c43e9914473ec073296c9
106 schema:familyName Park
107 schema:givenName Hye Ryeo
108 rdf:type schema:Person
109 N4eb014ac4b76496a9206eccecc4bbcba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Male
111 rdf:type schema:DefinedTerm
112 N5047582e1eff4310bfdf02696b3129a7 schema:name Food Functional Research Division, Korean Food Research Institutes, Seoul, Korea
113 rdf:type schema:Organization
114 N5770bab83e224043a5aa33d9f2a00a06 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Hypoglycemic Agents
116 rdf:type schema:DefinedTerm
117 N585c0e9b1a0b497a9e4d895d68a3cf72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Apoptosis
119 rdf:type schema:DefinedTerm
120 N5992eab74d2c483e981c34dad3218a37 rdf:first sg:person.07356627512.09
121 rdf:rest Ned4c4fe0e7c6412692f7a397764534b6
122 N60b808e78c80432ca7e29a5e31d03d0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Dexamethasone
124 rdf:type schema:DefinedTerm
125 N6b7b50d92f1940a4a8c4a8bcc4605596 schema:name readcube_id
126 schema:value 51dac539e203f55137f7f0f8a34ebc1bfe6429198a662fd383645350fcffde2d
127 rdf:type schema:PropertyValue
128 N6d13146359e74b56923ad4135f293dc2 schema:name Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea
129 rdf:type schema:Organization
130 N6d947e7776d94ad3839d9bcf556a5289 schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 N7618b5607fe746bea75a8e796ac3efc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Cell Division
134 rdf:type schema:DefinedTerm
135 N7c5e6f0c14b5494788f2137ee6049cff schema:issueNumber 1
136 rdf:type schema:PublicationIssue
137 N853011fab4ed4b028e49522804b9a669 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Glucose Clamp Technique
139 rdf:type schema:DefinedTerm
140 N8f137e45a6874088a9e61d7a97ef733d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Insulin-Secreting Cells
142 rdf:type schema:DefinedTerm
143 N93279ae06e1646a2954f106310e953c8 rdf:first sg:person.01355405676.20
144 rdf:rest Nacd4b772f6b442619a67a885b179caa4
145 N943efcee36e945e3b7520a7706cef362 schema:name Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea
146 rdf:type schema:Organization
147 N96ff3304fd8c42f4a248e8f0a1f0e51a rdf:first sg:person.01060641224.70
148 rdf:rest rdf:nil
149 N9bf99a9efc6548ab8e747f1f2c72bb2d schema:name Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea
150 rdf:type schema:Organization
151 N9f95606ed5e843dd85e45bb9dfaa905f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Rats
153 rdf:type schema:DefinedTerm
154 Na6df6b69a6a745d1988eacdda3a395cb schema:volumeNumber 46
155 rdf:type schema:PublicationVolume
156 Na9c5a0b292d34d9d8663079e0a64cf10 rdf:first sg:person.01246646361.35
157 rdf:rest N5992eab74d2c483e981c34dad3218a37
158 Nacd4b772f6b442619a67a885b179caa4 rdf:first sg:person.01362714013.22
159 rdf:rest N436a2b76978141628524cbb107e501e2
160 Nb55b43eed67240afad4b95ef738ebaa2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Immunohistochemistry
162 rdf:type schema:DefinedTerm
163 Nb8de530e0add471d8f5268290aa613f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Rats, Sprague-Dawley
165 rdf:type schema:DefinedTerm
166 Nbdeb449f62334eecb311f670ecb11cfb schema:name dimensions_id
167 schema:value pub.1017180523
168 rdf:type schema:PropertyValue
169 Nbf69eb5e155a4971823101d6d8909a0d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Pancreatectomy
171 rdf:type schema:DefinedTerm
172 Nc7a667a806564eb89280191397dd2b09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Random Allocation
174 rdf:type schema:DefinedTerm
175 Nc8568d3b394c43e9914473ec073296c9 schema:name Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea
176 rdf:type schema:Organization
177 Nc952e5e944924b23b510125c4080f96e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Cell Survival
179 rdf:type schema:DefinedTerm
180 Ncfd621872d204fc99a7e27349e5dd239 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Blood Glucose
182 rdf:type schema:DefinedTerm
183 Nd69fdf25fe134912939abd7e284c1439 schema:name Dept. of Food and Nutrition, Institute of Basic Sciences, Hoseo University, 165 Sechul-Ri Baebang-Myun Asan-Si, 336-795, Chungnam-Do, Korea
184 rdf:type schema:Organization
185 Nd8cd3adc4a0342319798723d9c9a6b21 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
186 schema:name Soy Foods
187 rdf:type schema:DefinedTerm
188 Ndb23a0c432d44c74b18e121dd7a5890b schema:name nlm_unique_id
189 schema:value 100888704
190 rdf:type schema:PropertyValue
191 Ne5226c92b66842d288e64bfb9b998240 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Insulin Secretion
193 rdf:type schema:DefinedTerm
194 Ned4c4fe0e7c6412692f7a397764534b6 rdf:first N47461ce383fc43efa03881e9f4cd87ad
195 rdf:rest N96ff3304fd8c42f4a248e8f0a1f0e51a
196 Nf0661397621c4d35acfb75c5c78d1a52 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Humans
198 rdf:type schema:DefinedTerm
199 Nf37a2efe10df4f1dbfd240085b53d183 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
200 schema:name Soybeans
201 rdf:type schema:DefinedTerm
202 Nf87dde5f97a442a1945c4392c3e5dcde schema:name doi
203 schema:value 10.1007/s00394-006-0630-y
204 rdf:type schema:PropertyValue
205 Nf99df8fd95194a5282af1b25e2e78635 schema:name pubmed_id
206 schema:value 17200876
207 rdf:type schema:PropertyValue
208 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
209 schema:name Medical and Health Sciences
210 rdf:type schema:DefinedTerm
211 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
212 schema:name Clinical Sciences
213 rdf:type schema:DefinedTerm
214 sg:journal.1294989 schema:issn 1435-1293
215 1436-6207
216 schema:name European Journal of Nutrition
217 rdf:type schema:Periodical
218 sg:person.01060641224.70 schema:affiliation N6d13146359e74b56923ad4135f293dc2
219 schema:familyName Park
220 schema:givenName Sunmin
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01060641224.70
222 rdf:type schema:Person
223 sg:person.01246646361.35 schema:affiliation N9bf99a9efc6548ab8e747f1f2c72bb2d
224 schema:familyName Lee
225 schema:givenName Ji Eun
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246646361.35
227 rdf:type schema:Person
228 sg:person.01355405676.20 schema:affiliation N5047582e1eff4310bfdf02696b3129a7
229 schema:familyName Kwon
230 schema:givenName Dae Young
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355405676.20
232 rdf:type schema:Person
233 sg:person.013610615374.90 schema:affiliation N163ee3ca9053486cb86a62afad8362f7
234 schema:familyName Hong
235 schema:givenName Sang Mee
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013610615374.90
237 rdf:type schema:Person
238 sg:person.01362714013.22 schema:affiliation N943efcee36e945e3b7520a7706cef362
239 schema:familyName Jang
240 schema:givenName Jin Sun
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362714013.22
242 rdf:type schema:Person
243 sg:person.07356627512.09 schema:affiliation Nd69fdf25fe134912939abd7e284c1439
244 schema:familyName Sung
245 schema:givenName So Ra
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07356627512.09
247 rdf:type schema:Person
248 sg:pub.10.1007/s00125-002-1009-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035282322
249 https://doi.org/10.1007/s00125-002-1009-0
250 rdf:type schema:CreativeWork
251 sg:pub.10.1007/s00125-003-1190-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030245545
252 https://doi.org/10.1007/s00125-003-1190-9
253 rdf:type schema:CreativeWork
254 sg:pub.10.1023/a:1006806722619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003203012
255 https://doi.org/10.1023/a:1006806722619
256 rdf:type schema:CreativeWork
257 sg:pub.10.1038/372182a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046415369
258 https://doi.org/10.1038/372182a0
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1002/(sici)1099-1573(199911)13:7<601::aid-ptr550>3.0.co;2-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1033844386
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1002/biof.5520260101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053168417
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1002/biof.5520260403 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033655527
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1002/jcp.10187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044682613
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.metabol.2005.06.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041204976
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1073/pnas.84.10.3434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050840325
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1074/jbc.m508307200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028354034
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1079/bjn2002720 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046514481
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1093/ajcn/68.6.1492s schema:sameAs https://app.dimensions.ai/details/publication/pub.1083359977
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1093/ajcn/76.6.1191 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075195874
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1093/jn/107.7.1340 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082934972
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1101/gad.1097103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051045522
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1111/j.1753-4887.2005.tb00141.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033567744
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1172/jci118387 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036376393
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1172/jci18581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043442132
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1172/jci21845 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024860834
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1172/jci22217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047716662
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1210/en.2004-1653 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247278
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1263/jbb.100.685 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044814601
297 rdf:type schema:CreativeWork
298 https://doi.org/10.2337/diabetes.51.3.686 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005587952
299 rdf:type schema:CreativeWork
300 https://doi.org/10.2337/diabetes.51.6.1825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044120088
301 rdf:type schema:CreativeWork
302 https://doi.org/10.2337/diabetes.53.2.441 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046903081
303 rdf:type schema:CreativeWork
304 https://doi.org/10.2337/diabetes.53.suppl_3.s16 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031925582
305 rdf:type schema:CreativeWork
306 https://doi.org/10.2337/diabetes.55.01.06.db05-0648 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009863994
307 rdf:type schema:CreativeWork
308 https://doi.org/10.2337/diabetes.55.04.06.db05-1089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021793432
309 rdf:type schema:CreativeWork
310 https://doi.org/10.2337/diacare.26.3.791 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018151237
311 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...