Effects of differing phenolic content in dietary olive oils on lipids and LDL oxidation View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-06

AUTHORS

Jaume Marrugat, María-Isabel Covas, Montserrat Fitó, Helmut Schröder, Elisabet Miró-Casas, Eva Gimeno, M. Carmen López-Sabater, Rafael de la Torre, Magí Farré, and the members of the SOLOS Investigators*

ABSTRACT

BACKGROUND: Evidence from in vitro studies suggests that antioxidant olive oil phenolic compounds can prevent LDL oxidation. However, in vivo evidence in support of this hypothesis is sparse. AIM OF THE STUDY: to establish the antioxidant effect of olive oils with differences in their phenolic compounds content in humans METHODS: A controlled, double blind, cross-over, randomized, clinical trial using three similar olive oils with increasing phenolic concentration (from 0 to 150 mg/Kg) was conducted in 30 healthy volunteers. Olive oils were administered over three periods of 3 weeks preceded by two-week washout periods. RESULTS: Urinary tyrosol and hydroxytyrosol increased (p < 0.020), in vivo plasma oxidized LDL decreased (p = 0.006), and ex vivo resistance of LDL to oxidation increased (p = 0.012) with the phenolic content of the olive oil administered. After virgin olive oil administration, an increase (p = 0.029) was observed in HDL cholesterol levels. CONCLUSIONS: Sustained consumption of virgin olive oil with the high phenolic content was more effective in protecting LDL from oxidation and in rising HDL cholesterol levels than that of other type of olive oils. Dose-dependent changes in oxidative stress markers, and phenolic compounds in urine, were observed with the phenolic content of the olive oil administered. Our results support the hypothesis that virgin olive oil consumption could provide benefits in the prevention of oxidative processes. More... »

PAGES

140-147

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00394-004-0452-8

DOI

http://dx.doi.org/10.1007/s00394-004-0452-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1040787899

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/15168036


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00394-004-0452-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00394-004-0452-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00394-004-0452-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00394-004-0452-8'


 

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292 Universitat Autònoma de Barcelona, Barcelona, Spain
293 Universitat Pompeu Fabra, Barcelona, Spain
294 rdf:type schema:Organization
295 https://www.grid.ac/institutes/grid.5841.8 schema:alternateName University of Barcelona
296 schema:name Dept. of Nutrition and Bromatology, Pharmacy Faculty, University of Barcelona, 08028, Barcelona, Spain
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298 https://www.grid.ac/institutes/grid.7080.f schema:alternateName Autonomous University of Barcelona
299 schema:name Lipids and Cardiovascular Epidemiology, Research Unit, Institut Municipal d’Investigació Mèdica, Carrer Dr Aiguader 80, 08003, Barcelona, Spain
300 Universitat Autònoma de Barcelona, Barcelona, Spain
301 rdf:type schema:Organization
 




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