„Therapierefraktäre Polymyositis“ – stimmt die Diagnose? View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-09

AUTHORS

G. Ceccon, H. C. Lehmann, E. Neuen-Jacob, G. Meng, G. R. Fink, G. Wunderlich

ABSTRACT

We report the case of a 32-year-old woman with severely elevated serum creatine kinase (CK; 80,000 U/l) and progressive proximal pareses. As muscular biopsy showed inflammatory infiltrates, polymyositis was suspected and immunosuppressive treatment was initiated. However, clinical improvement could not be achieved. Gene sequencing of the DYSF-gene showed a previously unreported homozygous mutation. In summary, elevated serum CK and inflammatory infiltrates in the muscle biopsy are not specific for polymyositis, but may also occur in degenerative diseases (muscular dystrophy), such as dysferlinopathy. More... »

PAGES

640-643

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00393-017-0326-0

DOI

http://dx.doi.org/10.1007/s00393-017-0326-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085436300

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28523511


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