Long-term outcome after thrombus aspiration in non-ST-elevation myocardial infarction: results from the TATORT-NSTEMI trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-02-06

AUTHORS

Hans-Josef Feistritzer, Roza Meyer-Saraei, Christiane Lober, Michael Böhm, Bruno Scheller, Bernward Lauer, Tobias Geisler, Meinrad Gawaz, Leonhard Bruch, Norbert Klein, Uwe Zeymer, Ingo Eitel, Alexander Jobs, Anne Freund, Steffen Desch, Suzanne de Waha-Thiele, Holger Thiele

ABSTRACT

AimsTo investigate the long-term prognostic value of aspiration thrombectomy in conjunction with primary percutaneous coronary intervention (PCI) compared to conventional PCI in patients with non-ST-elevation myocardial infarction (NSTEMI).MethodsIn the randomized TATORT-NSTEMI (Thrombus aspiration in thrombus containing culprit lesions in non-ST-elevation myocardial infarction) trial, NSTEMI patients with thrombus containing culprit lesions were randomized to either PCI with aspiration thrombectomy or conventional PCI. The endpoint was a combination of all-cause death, reinfarction and new congestive heart failure.ResultsFrom 440 patients initially randomized, outcome data were available in 432 (98.2%) patients at a median follow-up of 4.9 (interquartile range [IQR] 4.4–5.0) years. Thrombectomy was associated with a significant reduction of the combined endpoint compared to conventional PCI (19.9% vs. 30.7%, p = 0.01). This finding was primarily driven by a reduced rate of reinfarction with thrombectomy (3.4% vs. 10.3%, p = 0.01). Thrombectomy was still independently associated with the combined endpoint after multivariable adjustment (hazard ratio [HR] 0.47, 95% confidence interval [CI] 0.30–0.76, p = 0.002). Findings were consistent across all analyzed subgroups (p values for interaction all > 0.05).ConclusionsIn NSTEMI, thrombus aspiration is associated with favorable clinical outcome during long-term follow-up.Clinical trial registrationNCT01612312. More... »

PAGES

1223-1231

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00392-020-01613-0

DOI

http://dx.doi.org/10.1007/s00392-020-01613-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1124650533

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32030497


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24 schema:description AimsTo investigate the long-term prognostic value of aspiration thrombectomy in conjunction with primary percutaneous coronary intervention (PCI) compared to conventional PCI in patients with non-ST-elevation myocardial infarction (NSTEMI).MethodsIn the randomized TATORT-NSTEMI (Thrombus aspiration in thrombus containing culprit lesions in non-ST-elevation myocardial infarction) trial, NSTEMI patients with thrombus containing culprit lesions were randomized to either PCI with aspiration thrombectomy or conventional PCI. The endpoint was a combination of all-cause death, reinfarction and new congestive heart failure.ResultsFrom 440 patients initially randomized, outcome data were available in 432 (98.2%) patients at a median follow-up of 4.9 (interquartile range [IQR] 4.4–5.0) years. Thrombectomy was associated with a significant reduction of the combined endpoint compared to conventional PCI (19.9% vs. 30.7%, p = 0.01). This finding was primarily driven by a reduced rate of reinfarction with thrombectomy (3.4% vs. 10.3%, p = 0.01). Thrombectomy was still independently associated with the combined endpoint after multivariable adjustment (hazard ratio [HR] 0.47, 95% confidence interval [CI] 0.30–0.76, p = 0.002). Findings were consistent across all analyzed subgroups (p values for interaction all > 0.05).ConclusionsIn NSTEMI, thrombus aspiration is associated with favorable clinical outcome during long-term follow-up.Clinical trial registrationNCT01612312.
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