Thrombus aspiration in patients with ST-elevation myocardial infarction presenting late after symptom onset: long-term clinical outcome of a randomized trial View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-03-11

AUTHORS

Anne Freund, Sandra Schock, Thomas Stiermaier, Suzanne de Waha-Thiele, Ingo Eitel, Philipp Lurz, Holger Thiele, Steffen Desch

ABSTRACT

BackgroundIn the largest randomized trial so far, thrombus aspiration failed to reduce the primary endpoint of microvascular obstruction (MVO) in patients with ST-elevation myocardial infarction (STEMI) presenting late after symptom onset. Long-term clinical outcome data of this trial have not been reported yet.Methods and resultsA total of 144 patients with STEMI presenting ≥ 12 and ≤ 48 h after symptom onset were randomized to primary percutaneous coronary intervention (PCI) with or without manual thrombus aspiration in a 1:1 fashion. The primary efficacy endpoint was the extent of MVO assessed by cardiac magnetic resonance imaging and showed no significant difference between groups. Long-term clinical follow-up was performed at 4 years. Overall mortality at 4 years reached 18%. There was no significant difference between groups with respect to mortality and major adverse cardiac events defined as the composite of death, myocardial reinfarction and target vessel revascularization. In a multivariate Cox regression model glomerular filtration rate on admission, left ventricular ejection fraction, and cardiogenic shock were independently associated with time-dependent occurrence of death.ConclusionRoutine thrombus aspiration in STEMI patients presenting late after symptom onset showed no significant difference with respect to long-term clinical endpoints compared to conventional PCI only. More... »

PAGES

1208-1214

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00392-019-01452-8

DOI

http://dx.doi.org/10.1007/s00392-019-01452-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112683275

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30859380


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