Invasive hemodynamics and cardiac biomarkers to predict outcomes after percutaneous edge-to-edge mitral valve repair in patients with severe heart failure View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Michael M. Kreusser, Nicolas A. Geis, Nicolas Berlin, Sebastian Greiner, Sven T. Pleger, Raffi Bekeredjian, Hugo A. Katus, Philip W. Raake

ABSTRACT

BACKGROUND: Percutaneous mitral valve repair (PMVR) via MitraClip implantation is a therapeutic option for high-risk or non-surgical candidates with severe mitral regurgitation (MR) and advanced stages of heart failure (HF). However, these patients have a high mortality despite PMVR, and predictors for outcomes are not well established. Here, we evaluated invasive hemodynamics, echocardiography parameters, and biomarkers to predict outcomes after PMVR in severe HF patients. METHODS: Patients with reduced ejection fraction (EF) and severe and moderate-to-severe MR undergoing PMVR at our centre between September 2009 and January 2016 were analysed retrospectively. Inclusion criteria were: left ventricular EF < 45%, preoperative right heart catheterization, successful MitraClip deployment ("technical success"), and follow-up for at least 1 year after the procedure. Data from preoperative right heart catheterization, echocardiography, and biomarkers were assessed. Primary endpoint was all-cause mortality at 1 year after PMVR. We performed univariate and multivariate Cox regression analyses and generated a risk score to predict outcomes. RESULTS: Of 174 patients with PMVR and severe HF, 79.9% had functional MR. Mean EF was 25% (17.2; 30.7) and advanced New York Heart Association functional class was prevalent (class II: 13%; class III: 70%; and class IV: 17%). The cumulative incidences of all-cause death were 6.9% and 17.8% at 30 days and 1 year, respectively. In the Cox multivariate model, high-sensitive troponin T [hsTnT; hazard ratio (HR) 1.01; confidence interval (CI) 1.01-1.02; p < 0.0001] and mixed venous O2-saturation (HR 0.92; CI 0.89-0.96; p < 0.0001) were found to significantly and independently predict outcomes. A simple risk score including these two parameters was sufficient to discriminate between low- and high-risk patients (HR 7.22; CI 3.4-15.5; p < 0.001). CONCLUSION: In a cohort of patients with severe HF undergoing PMVR, patients with elevated hsTnT and reduced mixed venous O2-saturation carried the worst prognosis. A simple risk score including these two parameters may improve patient selection and outcomes after PMVR. More... »

PAGES

375-387

References to SciGraph publications

  • 2018-03. Association between hypo- and hyperkalemia and outcome in acute heart failure patients: the role of medications in CLINICAL RESEARCH IN CARDIOLOGY
  • 2016-06. Deep sedation versus general anesthesia in percutaneous edge-to-edge mitral valve reconstruction using the MitraClip system in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-04. Impact of cardiac comorbidities on early and 1-year outcome after percutaneous mitral valve interventions: data from the German transcatheter mitral valve interventions (TRAMI) registry in CLINICAL RESEARCH IN CARDIOLOGY
  • 2016-04. Transcatheter mitral valve repair with the MitraClip® can be performed without general anesthesia and without conscious sedation in CLINICAL RESEARCH IN CARDIOLOGY
  • 2016-01. Long-term changes in renal function and perfusion in heart failure patients with reduced ejection fraction in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-12. Functional status and quality of life after transcatheter mitral valve repair: a prospective cohort study and systematic review in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-10. Implantation of CARILLON® Mitral Contour System with transvenous left ventricular lead in place in CLINICAL RESEARCH IN CARDIOLOGY
  • 2016-05. Myocardial injury associated with transcatheter aortic valve implantation (TAVI) in CLINICAL RESEARCH IN CARDIOLOGY
  • 2018-08. Indication and short-term clinical outcomes of high-risk percutaneous coronary intervention with microaxial Impella® pump: results from the German Impella® registry in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-12. Biological variation of extracellular matrix biomarkers in patients with stable chronic heart failure in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-12. Comparison of outcomes using balloon-expandable versus self-expanding transcatheter prostheses according to the extent of aortic valve calcification in CLINICAL RESEARCH IN CARDIOLOGY
  • 2016-01. Invasive hemodynamic assessments during transcatheter aortic valve implantation: comparison of patient outcomes in higher vs. lower transvalvular gradients with respect to left ventricular ejection fraction in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-06. Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-02. Comment to: De Waha S, Seeburger J et al. (2016): Deep sedation versus general anaesthesia in percutaneous edge-to edge mitral valve reconstruction using the MitraClip system. Clin Res Cardiol 105(6):535–43 in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-05. Impact of baseline tricuspid regurgitation on long-term clinical outcomes and survival after interventional edge-to-edge repair for mitral regurgitation in CLINICAL RESEARCH IN CARDIOLOGY
  • 2016-05. Discordant cardiac biomarker levels independently predict outcome in ST-segment elevation myocardial infarction in CLINICAL RESEARCH IN CARDIOLOGY
  • 2018-03. Prognostic value of preprocedural 6-min walk test in patients undergoing transcatheter mitral valve repair—insights from the German transcatheter mitral valve interventions registry in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-05. Incidence, laboratory detection and prognostic relevance of hypoxic hepatitis in cardiogenic shock in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-03. Low level exercise echocardiography helps diagnose early stage heart failure with preserved ejection fraction: a study of echocardiography versus catheterization in CLINICAL RESEARCH IN CARDIOLOGY
  • 2017-12. Circadian rhythm of blood cardiac troponin T concentration in CLINICAL RESEARCH IN CARDIOLOGY
  • 2016-12. Similar hemodynamic decongestion with vasodilators and inotropes: systematic review, meta-analysis, and meta-regression of 35 studies on acute heart failure in CLINICAL RESEARCH IN CARDIOLOGY
  • 2018-01. Effect of eplerenone on extracellular cardiac matrix biomarkers in patients with acute ST-elevation myocardial infarction without heart failure: insights from the randomized double-blind REMINDER Study in CLINICAL RESEARCH IN CARDIOLOGY
  • 2016-02. A combined clinical and biomarker approach to predict diuretic response in acute heart failure in CLINICAL RESEARCH IN CARDIOLOGY
  • 2016-08. Prevalence of severe mitral regurgitation eligible for edge-to-edge mitral valve repair (MitraClip) in CLINICAL RESEARCH IN CARDIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00392-018-1365-5

    DOI

    http://dx.doi.org/10.1007/s00392-018-1365-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1106804052

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30191296


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    74 schema:description BACKGROUND: Percutaneous mitral valve repair (PMVR) via MitraClip implantation is a therapeutic option for high-risk or non-surgical candidates with severe mitral regurgitation (MR) and advanced stages of heart failure (HF). However, these patients have a high mortality despite PMVR, and predictors for outcomes are not well established. Here, we evaluated invasive hemodynamics, echocardiography parameters, and biomarkers to predict outcomes after PMVR in severe HF patients. METHODS: Patients with reduced ejection fraction (EF) and severe and moderate-to-severe MR undergoing PMVR at our centre between September 2009 and January 2016 were analysed retrospectively. Inclusion criteria were: left ventricular EF < 45%, preoperative right heart catheterization, successful MitraClip deployment ("technical success"), and follow-up for at least 1 year after the procedure. Data from preoperative right heart catheterization, echocardiography, and biomarkers were assessed. Primary endpoint was all-cause mortality at 1 year after PMVR. We performed univariate and multivariate Cox regression analyses and generated a risk score to predict outcomes. RESULTS: Of 174 patients with PMVR and severe HF, 79.9% had functional MR. Mean EF was 25% (17.2; 30.7) and advanced New York Heart Association functional class was prevalent (class II: 13%; class III: 70%; and class IV: 17%). The cumulative incidences of all-cause death were 6.9% and 17.8% at 30 days and 1 year, respectively. In the Cox multivariate model, high-sensitive troponin T [hsTnT; hazard ratio (HR) 1.01; confidence interval (CI) 1.01-1.02; p < 0.0001] and mixed venous O2-saturation (HR 0.92; CI 0.89-0.96; p < 0.0001) were found to significantly and independently predict outcomes. A simple risk score including these two parameters was sufficient to discriminate between low- and high-risk patients (HR 7.22; CI 3.4-15.5; p < 0.001). CONCLUSION: In a cohort of patients with severe HF undergoing PMVR, patients with elevated hsTnT and reduced mixed venous O2-saturation carried the worst prognosis. A simple risk score including these two parameters may improve patient selection and outcomes after PMVR.
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