Interventional treatment of paravalvular regurgitation by plug implantation following prosthetic valve replacement: a single-center experience View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12

AUTHORS

Nicolas Werner, Uwe Zeymer, Boris Fraiture, Caroline Kilkowski, Patrick Riedmaier, Steffen Schneider, Ralf Zahn

ABSTRACT

BACKGROUND: Interventional closure of paravalvular leaks (PVL) by plug implantation has emerged as an alternative to surgical correction, which is associated with high mortality rates for re-operation. To date, data on procedural efficacy and clinical outcome after transcatheter closure is sparse. We present our experience with interventional PVL closure at our site. METHODS AND RESULTS: From 08/2014 to 10/2016 ten patients (three women, seven men) at high surgical risk for repeat surgery underwent interventional PVL closure for severe paravalvular regurgitation (PVR) in 14 procedures at our site. Nine procedures (64%) were performed for mitral PVLs, five procedures were performed for aortic PVLs (36%). Mean age of the population treated was 70 ± 8.6 years and mean log. Euro-Score I was 27.4 ± 14.9%. All patients were treated by implantation of Amplatzer Vascular Plug III occluders. All aortic PVLs were treated using a retrograde transfemoral access, mitral PVLs were treated using either a transseptal (8/9) or transapical access (1/9) under 3-dimensional transesophageal echocardiographic and fluoroscopic guidance. Indication for PVL closure was the presence of severe heart failure symptoms in all patients (NYHA class III/IV, n = 14) and additional mechanical hemolytic anemia (n = 5) with a need for transfusion. Interventional closure of PVL was completely successful in 12 procedures (85%), partially successful in one procedure due to inability to cross the defect with a wire (7.5%) and failed in one of 14 procedures due to inability of plug deployment in a very large defect (7.5%). One patient in a critical clinical condition died within 24 h after procedure due to progressive cardiogenic shock after procedural failure and refusal of a surgical treatment by cardiac surgeons. After interventional treatment clinical success with improvement in NYHA functional class or hemolysis was achieved in 93% (13/14). Median NYHA class improved significantly from 4 prior to procedure to 2 after PVL closure (p = 0.0005). Severe PVR was significantly reduced to mild in six patients and to moderate in three patients after procedure (p = 0.001). Complications included one hemothorax after transapical access and one pseudoaneurysm after transfemoral arterial access. In-hospital mortality rate was 20% (2/10) in this high-risk population. After hospital discharge no death occurred during 30-day follow-up, one patient died during 1-year follow-up after PVL closure. CONCLUSION: In this single-center series interventional PVL closure appears promising for patients at high surgical risk with symptomatic paravalvular regurgitation. Gaining experience in interventional PVL closure at specialized sites will further improve safety and efficacy of this relatively new treatment option. All patients should be treated within large clinical registries to gain more data on mid- and long-term efficacy of transcatheter PVL closure. More... »

PAGES

1160-1169

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00392-018-1290-7

DOI

http://dx.doi.org/10.1007/s00392-018-1290-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104548434

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29948288


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aortic Valve Insufficiency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Echocardiography, Three-Dimensional", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Echocardiography, Transesophageal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluoroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Valve Prosthesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heart Valve Prosthesis Implantation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hospital Mortality", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitral Valve Insufficiency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prosthesis Failure", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Septal Occluder Device", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Medizinische Klinik B, Klinikum Ludwigshafen, Bremserstra\u00dfe 79, 67063, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Werner", 
        "givenName": "Nicolas", 
        "id": "sg:person.01347400701.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347400701.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Medizinische Klinik B, Klinikum Ludwigshafen, Bremserstra\u00dfe 79, 67063, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zeymer", 
        "givenName": "Uwe", 
        "id": "sg:person.01206257120.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206257120.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Medizinische Klinik B, Klinikum Ludwigshafen, Bremserstra\u00dfe 79, 67063, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fraiture", 
        "givenName": "Boris", 
        "id": "sg:person.0602447537.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602447537.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Medizinische Klinik B, Klinikum Ludwigshafen, Bremserstra\u00dfe 79, 67063, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kilkowski", 
        "givenName": "Caroline", 
        "id": "sg:person.01252407537.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252407537.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Medizinische Klinik B, Klinikum Ludwigshafen, Bremserstra\u00dfe 79, 67063, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Riedmaier", 
        "givenName": "Patrick", 
        "id": "sg:person.016256730430.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016256730430.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Stiftung Institut f\u00fcr Herzinfarktforschung", 
          "id": "https://www.grid.ac/institutes/grid.488379.9", 
          "name": [
            "Institut f\u00fcr Herzinfarktforschung, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schneider", 
        "givenName": "Steffen", 
        "id": "sg:person.011364136412.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011364136412.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Klinikum Ludwigshafen", 
          "id": "https://www.grid.ac/institutes/grid.413225.3", 
          "name": [
            "Medizinische Klinik B, Klinikum Ludwigshafen, Bremserstra\u00dfe 79, 67063, Ludwigshafen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zahn", 
        "givenName": "Ralf", 
        "id": "sg:person.01016713172.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016713172.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/ccd.20795", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000630664"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00392-016-1038-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005345087", 
          "https://doi.org/10.1007/s00392-016-1038-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00392-016-1038-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005345087", 
          "https://doi.org/10.1007/s00392-016-1038-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcin.2011.05.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007825815"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0002-9149(60)90361-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010466843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2011.03.074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011991891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2011.07.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013672696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ccd.21270", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018567565"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcin.2014.01.159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019514398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcin.2010.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022429022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-8932(09)72076-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024321600"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-8703(99)70124-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027123530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-8932(09)70901-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031486682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circinterventions.110.960955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032150712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circinterventions.110.960955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032150712"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0735-1097(00)00834-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032736760"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0735-1097(92)90250-q", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033673124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0300-8932(09)70902-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043838397"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/heart.89.11.1316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050215124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehs347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050355621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1010-7940(91)90105-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054567476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1010-7940(02)00583-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054670041"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.116.022684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063344527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.116.022684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063344527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077163048", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077957223", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078835222", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4244/eij-d-16-00581", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079377670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehx391", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091616734"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-12", 
    "datePublishedReg": "2018-12-01", 
    "description": "BACKGROUND: Interventional closure of paravalvular leaks (PVL) by plug implantation has emerged as an alternative to surgical correction, which is associated with high mortality rates for re-operation. To date, data on procedural efficacy and clinical outcome after transcatheter closure is sparse. We present our experience with interventional PVL closure at our site.\nMETHODS AND RESULTS: From 08/2014 to 10/2016 ten patients (three women, seven men) at high surgical risk for repeat surgery underwent interventional PVL closure for severe paravalvular regurgitation (PVR) in 14 procedures at our site. Nine procedures (64%) were performed for mitral PVLs, five procedures were performed for aortic PVLs (36%). Mean age of the population treated was 70\u2009\u00b1\u20098.6\u00a0years and mean log. Euro-Score I was 27.4\u2009\u00b1\u200914.9%. All patients were treated by implantation of Amplatzer Vascular Plug III occluders. All aortic PVLs were treated using a retrograde transfemoral access, mitral PVLs were treated using either a transseptal (8/9) or transapical access (1/9) under 3-dimensional transesophageal echocardiographic and fluoroscopic guidance. Indication for PVL closure was the presence of severe heart failure symptoms in all patients (NYHA class III/IV, n\u2009=\u200914) and additional mechanical hemolytic anemia (n\u2009=\u20095) with a need for transfusion. Interventional closure of PVL was completely successful in 12 procedures (85%), partially successful in one procedure due to inability to cross the defect with a wire (7.5%) and failed in one of 14 procedures due to inability of plug deployment in a very large defect (7.5%). One patient in a critical clinical condition died within 24\u00a0h after procedure due to progressive cardiogenic shock after procedural failure and refusal of a surgical treatment by cardiac surgeons. After interventional treatment clinical success with improvement in NYHA functional class or hemolysis was achieved in 93% (13/14). Median NYHA class improved significantly from 4 prior to procedure to 2 after PVL closure (p\u2009=\u20090.0005). Severe PVR was significantly reduced to mild in six patients and to moderate in three patients after procedure (p\u2009=\u20090.001). Complications included one hemothorax after transapical access and one pseudoaneurysm after transfemoral arterial access. In-hospital mortality rate was 20% (2/10) in this high-risk population. After hospital discharge no death occurred during 30-day follow-up, one patient died during 1-year follow-up after PVL closure.\nCONCLUSION: In this single-center series interventional PVL closure appears promising for patients at high surgical risk with symptomatic paravalvular regurgitation. Gaining experience in interventional PVL closure at specialized sites will further improve safety and efficacy of this relatively new treatment option. All patients should be treated within large clinical registries to gain more data on mid- and long-term efficacy of transcatheter PVL closure.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00392-018-1290-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297382", 
        "issn": [
          "1861-0684", 
          "1861-0692"
        ], 
        "name": "Clinical Research in Cardiology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "107"
      }
    ], 
    "name": "Interventional treatment of paravalvular regurgitation by plug implantation following prosthetic valve replacement: a single-center experience", 
    "pagination": "1160-1169", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0fda737e4092ccd5892685ba130f73d0298913aaf753c9aff6d1e6e38f3c9d0f"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29948288"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101264123"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00392-018-1290-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1104548434"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00392-018-1290-7", 
      "https://app.dimensions.ai/details/publication/pub.1104548434"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:16", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11691_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs00392-018-1290-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00392-018-1290-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00392-018-1290-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00392-018-1290-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00392-018-1290-7'


 

This table displays all metadata directly associated to this object as RDF triples.

258 TRIPLES      21 PREDICATES      72 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00392-018-1290-7 schema:about N013129cc012d4838bc8c3af5394f6ea3
2 N14af323167a64dad8be0f6c3b82273f7
3 N23da0533f14644adbb13e94582a98482
4 N394ee6af80984c1bb072bc5864e67c26
5 N4d59821483de42e49acba9f31aa0ea36
6 N4de7c534caa5443a98a3391fbadfa6d4
7 N6c9d579344ad4796baff1f9407bdcbdc
8 N73d4f5d0bfab498888d758e047b562f0
9 N7b5f8e0b295d434dba07121cd8b26efa
10 N807d78bbd61843c686a3ee15b0768670
11 N850bcb4a540d4417bb2cb82321023b6f
12 N9b500313cca14566844423881f05d7c3
13 N9c5f4d51d96f43188e5637a6fe02538e
14 N9edbeb111b8e4717a175e0417ff78d62
15 Na8e9e5ca3be74dc4b2913409b2610d93
16 Nec079a2ed16d41c19683b2ddcbf487b6
17 Nf18dd78cbaa84ab8ac1cb12ded450518
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N525545348209477f89927cf0989f474b
21 schema:citation sg:pub.10.1007/s00392-016-1038-1
22 https://app.dimensions.ai/details/publication/pub.1077163048
23 https://app.dimensions.ai/details/publication/pub.1077957223
24 https://app.dimensions.ai/details/publication/pub.1078835222
25 https://doi.org/10.1002/ccd.20795
26 https://doi.org/10.1002/ccd.21270
27 https://doi.org/10.1016/0002-9149(60)90361-1
28 https://doi.org/10.1016/0735-1097(92)90250-q
29 https://doi.org/10.1016/1010-7940(91)90105-s
30 https://doi.org/10.1016/j.jacc.2011.03.074
31 https://doi.org/10.1016/j.jacc.2011.07.041
32 https://doi.org/10.1016/j.jcin.2010.04.013
33 https://doi.org/10.1016/j.jcin.2011.05.018
34 https://doi.org/10.1016/j.jcin.2014.01.159
35 https://doi.org/10.1016/s0002-8703(99)70124-9
36 https://doi.org/10.1016/s0300-8932(09)70901-7
37 https://doi.org/10.1016/s0300-8932(09)70902-9
38 https://doi.org/10.1016/s0300-8932(09)72076-7
39 https://doi.org/10.1016/s0735-1097(00)00834-2
40 https://doi.org/10.1016/s1010-7940(02)00583-3
41 https://doi.org/10.1093/eurheartj/ehs347
42 https://doi.org/10.1093/eurheartj/ehx391
43 https://doi.org/10.1136/heart.89.11.1316
44 https://doi.org/10.1161/circinterventions.110.960955
45 https://doi.org/10.1161/circulationaha.116.022684
46 https://doi.org/10.4244/eij-d-16-00581
47 schema:datePublished 2018-12
48 schema:datePublishedReg 2018-12-01
49 schema:description BACKGROUND: Interventional closure of paravalvular leaks (PVL) by plug implantation has emerged as an alternative to surgical correction, which is associated with high mortality rates for re-operation. To date, data on procedural efficacy and clinical outcome after transcatheter closure is sparse. We present our experience with interventional PVL closure at our site. METHODS AND RESULTS: From 08/2014 to 10/2016 ten patients (three women, seven men) at high surgical risk for repeat surgery underwent interventional PVL closure for severe paravalvular regurgitation (PVR) in 14 procedures at our site. Nine procedures (64%) were performed for mitral PVLs, five procedures were performed for aortic PVLs (36%). Mean age of the population treated was 70 ± 8.6 years and mean log. Euro-Score I was 27.4 ± 14.9%. All patients were treated by implantation of Amplatzer Vascular Plug III occluders. All aortic PVLs were treated using a retrograde transfemoral access, mitral PVLs were treated using either a transseptal (8/9) or transapical access (1/9) under 3-dimensional transesophageal echocardiographic and fluoroscopic guidance. Indication for PVL closure was the presence of severe heart failure symptoms in all patients (NYHA class III/IV, n = 14) and additional mechanical hemolytic anemia (n = 5) with a need for transfusion. Interventional closure of PVL was completely successful in 12 procedures (85%), partially successful in one procedure due to inability to cross the defect with a wire (7.5%) and failed in one of 14 procedures due to inability of plug deployment in a very large defect (7.5%). One patient in a critical clinical condition died within 24 h after procedure due to progressive cardiogenic shock after procedural failure and refusal of a surgical treatment by cardiac surgeons. After interventional treatment clinical success with improvement in NYHA functional class or hemolysis was achieved in 93% (13/14). Median NYHA class improved significantly from 4 prior to procedure to 2 after PVL closure (p = 0.0005). Severe PVR was significantly reduced to mild in six patients and to moderate in three patients after procedure (p = 0.001). Complications included one hemothorax after transapical access and one pseudoaneurysm after transfemoral arterial access. In-hospital mortality rate was 20% (2/10) in this high-risk population. After hospital discharge no death occurred during 30-day follow-up, one patient died during 1-year follow-up after PVL closure. CONCLUSION: In this single-center series interventional PVL closure appears promising for patients at high surgical risk with symptomatic paravalvular regurgitation. Gaining experience in interventional PVL closure at specialized sites will further improve safety and efficacy of this relatively new treatment option. All patients should be treated within large clinical registries to gain more data on mid- and long-term efficacy of transcatheter PVL closure.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf N4515ea2c41714fb8a5e686f5ee63bf34
54 Nfadfeaa65a00493d88c6ebf9935fdf90
55 sg:journal.1297382
56 schema:name Interventional treatment of paravalvular regurgitation by plug implantation following prosthetic valve replacement: a single-center experience
57 schema:pagination 1160-1169
58 schema:productId N2ac529daa7ff4c57b919f9a6f85a1c6a
59 N82593b858fa041cab4fa598274207a8b
60 N8e52d0a92e6743c8b77ffdf50ba09e3c
61 Na256579f0a374894ba5b345dd3e2d228
62 Nc51d81cc3b0e42539ffcdff7ff96351f
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104548434
64 https://doi.org/10.1007/s00392-018-1290-7
65 schema:sdDatePublished 2019-04-11T11:16
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher Nc56275ecc1564015b5f3da6153fea610
68 schema:url https://link.springer.com/10.1007%2Fs00392-018-1290-7
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N013129cc012d4838bc8c3af5394f6ea3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Humans
74 rdf:type schema:DefinedTerm
75 N14af323167a64dad8be0f6c3b82273f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Septal Occluder Device
77 rdf:type schema:DefinedTerm
78 N161e62918586420c98610414b181cc83 rdf:first sg:person.01252407537.82
79 rdf:rest N24307961e4e74247b17a384f85ade7b5
80 N23da0533f14644adbb13e94582a98482 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
81 schema:name Female
82 rdf:type schema:DefinedTerm
83 N24307961e4e74247b17a384f85ade7b5 rdf:first sg:person.016256730430.03
84 rdf:rest Nd569962adaba4507a71b6116264d5888
85 N2ac529daa7ff4c57b919f9a6f85a1c6a schema:name pubmed_id
86 schema:value 29948288
87 rdf:type schema:PropertyValue
88 N394ee6af80984c1bb072bc5864e67c26 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Aged
90 rdf:type schema:DefinedTerm
91 N3cffec9ae5db47359a54270f46fb2c88 rdf:first sg:person.01016713172.96
92 rdf:rest rdf:nil
93 N4515ea2c41714fb8a5e686f5ee63bf34 schema:volumeNumber 107
94 rdf:type schema:PublicationVolume
95 N4d59821483de42e49acba9f31aa0ea36 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Heart Valve Prosthesis
97 rdf:type schema:DefinedTerm
98 N4de7c534caa5443a98a3391fbadfa6d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Hospital Mortality
100 rdf:type schema:DefinedTerm
101 N525545348209477f89927cf0989f474b rdf:first sg:person.01347400701.45
102 rdf:rest N5871272c2f2e44bead24f469fab8aff4
103 N5871272c2f2e44bead24f469fab8aff4 rdf:first sg:person.01206257120.28
104 rdf:rest N5d97a590b40e4e32962ef02fcdc46749
105 N5d97a590b40e4e32962ef02fcdc46749 rdf:first sg:person.0602447537.34
106 rdf:rest N161e62918586420c98610414b181cc83
107 N6c9d579344ad4796baff1f9407bdcbdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Aortic Valve Insufficiency
109 rdf:type schema:DefinedTerm
110 N73d4f5d0bfab498888d758e047b562f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Mitral Valve Insufficiency
112 rdf:type schema:DefinedTerm
113 N7b5f8e0b295d434dba07121cd8b26efa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Prosthesis Failure
115 rdf:type schema:DefinedTerm
116 N807d78bbd61843c686a3ee15b0768670 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Echocardiography, Three-Dimensional
118 rdf:type schema:DefinedTerm
119 N82593b858fa041cab4fa598274207a8b schema:name dimensions_id
120 schema:value pub.1104548434
121 rdf:type schema:PropertyValue
122 N850bcb4a540d4417bb2cb82321023b6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Echocardiography, Transesophageal
124 rdf:type schema:DefinedTerm
125 N8e52d0a92e6743c8b77ffdf50ba09e3c schema:name readcube_id
126 schema:value 0fda737e4092ccd5892685ba130f73d0298913aaf753c9aff6d1e6e38f3c9d0f
127 rdf:type schema:PropertyValue
128 N9b500313cca14566844423881f05d7c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Fluoroscopy
130 rdf:type schema:DefinedTerm
131 N9c5f4d51d96f43188e5637a6fe02538e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Middle Aged
133 rdf:type schema:DefinedTerm
134 N9edbeb111b8e4717a175e0417ff78d62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Follow-Up Studies
136 rdf:type schema:DefinedTerm
137 Na256579f0a374894ba5b345dd3e2d228 schema:name doi
138 schema:value 10.1007/s00392-018-1290-7
139 rdf:type schema:PropertyValue
140 Na8e9e5ca3be74dc4b2913409b2610d93 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Heart Valve Prosthesis Implantation
142 rdf:type schema:DefinedTerm
143 Nc51d81cc3b0e42539ffcdff7ff96351f schema:name nlm_unique_id
144 schema:value 101264123
145 rdf:type schema:PropertyValue
146 Nc56275ecc1564015b5f3da6153fea610 schema:name Springer Nature - SN SciGraph project
147 rdf:type schema:Organization
148 Nd569962adaba4507a71b6116264d5888 rdf:first sg:person.011364136412.97
149 rdf:rest N3cffec9ae5db47359a54270f46fb2c88
150 Nec079a2ed16d41c19683b2ddcbf487b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Male
152 rdf:type schema:DefinedTerm
153 Nf18dd78cbaa84ab8ac1cb12ded450518 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Treatment Outcome
155 rdf:type schema:DefinedTerm
156 Nfadfeaa65a00493d88c6ebf9935fdf90 schema:issueNumber 12
157 rdf:type schema:PublicationIssue
158 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
159 schema:name Medical and Health Sciences
160 rdf:type schema:DefinedTerm
161 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
162 schema:name Clinical Sciences
163 rdf:type schema:DefinedTerm
164 sg:journal.1297382 schema:issn 1861-0684
165 1861-0692
166 schema:name Clinical Research in Cardiology
167 rdf:type schema:Periodical
168 sg:person.01016713172.96 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
169 schema:familyName Zahn
170 schema:givenName Ralf
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016713172.96
172 rdf:type schema:Person
173 sg:person.011364136412.97 schema:affiliation https://www.grid.ac/institutes/grid.488379.9
174 schema:familyName Schneider
175 schema:givenName Steffen
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011364136412.97
177 rdf:type schema:Person
178 sg:person.01206257120.28 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
179 schema:familyName Zeymer
180 schema:givenName Uwe
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206257120.28
182 rdf:type schema:Person
183 sg:person.01252407537.82 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
184 schema:familyName Kilkowski
185 schema:givenName Caroline
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01252407537.82
187 rdf:type schema:Person
188 sg:person.01347400701.45 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
189 schema:familyName Werner
190 schema:givenName Nicolas
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347400701.45
192 rdf:type schema:Person
193 sg:person.016256730430.03 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
194 schema:familyName Riedmaier
195 schema:givenName Patrick
196 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016256730430.03
197 rdf:type schema:Person
198 sg:person.0602447537.34 schema:affiliation https://www.grid.ac/institutes/grid.413225.3
199 schema:familyName Fraiture
200 schema:givenName Boris
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602447537.34
202 rdf:type schema:Person
203 sg:pub.10.1007/s00392-016-1038-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005345087
204 https://doi.org/10.1007/s00392-016-1038-1
205 rdf:type schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1077163048 schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1077957223 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1078835222 schema:CreativeWork
209 https://doi.org/10.1002/ccd.20795 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000630664
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1002/ccd.21270 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018567565
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0002-9149(60)90361-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010466843
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/0735-1097(92)90250-q schema:sameAs https://app.dimensions.ai/details/publication/pub.1033673124
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/1010-7940(91)90105-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1054567476
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.jacc.2011.03.074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011991891
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.jacc.2011.07.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013672696
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.jcin.2010.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022429022
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.jcin.2011.05.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007825815
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.jcin.2014.01.159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019514398
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0002-8703(99)70124-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027123530
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/s0300-8932(09)70901-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031486682
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/s0300-8932(09)70902-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043838397
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s0300-8932(09)72076-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024321600
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0735-1097(00)00834-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032736760
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s1010-7940(02)00583-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054670041
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1093/eurheartj/ehs347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050355621
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1093/eurheartj/ehx391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091616734
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1136/heart.89.11.1316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050215124
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1161/circinterventions.110.960955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032150712
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1161/circulationaha.116.022684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063344527
250 rdf:type schema:CreativeWork
251 https://doi.org/10.4244/eij-d-16-00581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079377670
252 rdf:type schema:CreativeWork
253 https://www.grid.ac/institutes/grid.413225.3 schema:alternateName Klinikum Ludwigshafen
254 schema:name Medizinische Klinik B, Klinikum Ludwigshafen, Bremserstraße 79, 67063, Ludwigshafen, Germany
255 rdf:type schema:Organization
256 https://www.grid.ac/institutes/grid.488379.9 schema:alternateName Stiftung Institut für Herzinfarktforschung
257 schema:name Institut für Herzinfarktforschung, Ludwigshafen, Germany
258 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...