Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-02

AUTHORS

Theodora Nikolaidou, Pierpaolo Pellicori, Jufen Zhang, Syed Kazmi, Kevin M. Goode, John G. Cleland, Andrew L. Clark

ABSTRACT

AIMS: To determine the prevalence, incidence, predictors, and prognostic implications of PR interval prolongation in patients referred with suspected heart failure. METHODS AND RESULTS: Consecutive patients referred with suspected heart failure were prospectively enrolled. After excluding patients with implantable cardiac devices and atrial fibrillation, 1420 patients with heart failure and reduced ejection fraction (HeFREF) [age: median 71 (interquartile range IQR 63-78) years; men: 71%; NT-ProBNP: 1319 (583-3378) ng/L], 1094 with heart failure and normal ejection fraction (HeFNEF) [age: 76 (70-82) years; men: 47%; NT-ProBNP: 547 (321-1171) ng/L], and 1150 without heart failure [age: 68 (60-75) years; men: 51%; NT-ProBNP: 86 (46-140) ng/L] were included. The prevalence of first-degree heart block [heart rate corrected PR interval (PRc) > 200 ms] was higher in patients with heart failure (21% HeFREF, 20% HeFNEF, 9% without heart failure). In patients with HeFREF or HeFNEF, longer baseline PRc was associated with greater age, male sex, and longer QRS duration, and, in those with HeFREF, treatment with amiodarone or digoxin. Patients with heart failure in the longest PRc quartile had worse survival compared to shorter PRc quartiles, but PRc was not independently associated with survival in multivariable analysis. For patients without heart failure, shorter baseline PRc was independently associated with worse survival. CONCLUSION: PRc prolongation is common in patients with HeFREF or HeFNEF and associated with worse survival, although not an independent predictor of outcome. The results of clinical trials investigating the therapeutic potential of shortening the PR interval by pacing are awaited. More... »

PAGES

108-119

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00392-017-1162-6

DOI

http://dx.doi.org/10.1007/s00392-017-1162-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1091774709

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28917011


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Download the RDF metadata as:  json-ld nt turtle xml License info

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00392-017-1162-6'


 

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318 National Heart and Lung Institute, Imperial College London and Robertson Centre for Biostatistics and Clinical Trials, University of Glasgow, Glasgow, UK
319 rdf:type schema:Organization
320 https://www.grid.ac/institutes/grid.9481.4 schema:alternateName University of Hull
321 schema:name Department of Academic Cardiology, Castle Hill Hospital, University of Hull, Level 1 Daisy Building, Castle Road, HU16 5JQ, Hull, UK
322 rdf:type schema:Organization
 




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