A multicenter randomized comparison of paclitaxel-coated balloon with plain balloon angioplasty in patients with small vessel disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06-06

AUTHORS

Atsushi Funatsu, Shigeru Nakamura, Naoto Inoue, Shinsuke Nanto, Masato Nakamura, Masashi Iwabuchi, Kenji Ando, Ryuta Asano, Seiji Habara, Shigeru Saito, Ken kozuma, Kazuaki Mitsudo

ABSTRACT

AimWe investigated the efficacy and safety of using paclitaxel-coated balloon (PCB) to treat small vessel disease.Methods and resultsIn this multicenter, prospective, randomized controlled trial, one-hundred and thirty-five patients with native coronary lesions in small vessels were randomized into a PCB group and plain balloon angioplasty (POBA) group at a ratio of 2:1. There were no differences in target vessel failure (TVF) that was defined as cardiac death or target vessel-related myocardial infarction or target lesion revascularization (TLR), between the two groups (3.4 vs. 10.3%; P = 0.20), and TLR was slightly lower in the PCB group (2.3%) than that in the POBA group (10.3%) during 24 weeks follow-up. The late lumen loss (LLL) was significantly lower in the PCB group (0.01 ± 0.31 vs. 0.32 ± 0.34 mm; P < 0.01) and late lumen enlargement (LLE) was more frequently observed in the PCB group (48 vs. 15%; P < 0.01) by angiographic follow-up after 24 weeks. There were no cases of death, myocardial infarction, thrombosis and reocclusion in either group.ConclusionsThis study was not able to demonstrate superiority of PCB compared with POBA. More... »

PAGES

824-832

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00392-017-1126-x

DOI

http://dx.doi.org/10.1007/s00392-017-1126-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1085886243

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28589231


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