Factors independently associated with cardiac troponin I levels in young and healthy adults from the general population View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02

AUTHORS

Matthias Bossard, Sébastien Thériault, Stefanie Aeschbacher, Tobias Schoen, Seraina Kunz, Mirco von Rotz, Joel Estis, John Todd, Martin Risch, Christian Mueller, Lorenz Risch, Guillaume Paré, David Conen

ABSTRACT

BACKGROUND: Determinants of cardiomyocyte injury as quantified by high-sensitivity cardiac troponin I (cTnI) in young and healthy individuals, and sex-specific 99th percentiles are largely unknown. METHODS: Our study included 2077 adults from the general population aged 25-41 years without cardiovascular disease. cTnI was measured using a high-sensitivity assay. We performed stepwise backward linear regression analyses to identify variables independently associated with hs-cTnI levels, and calculated narrow-sense heritability from 1638-genotyped participants. RESULTS: Median age was 37 years. cTnI was quantifiable in all but 11 participants (99.5 %). Median (interquartile range) cTnI was significantly higher in men than in women [0.99 (0.71; 1.65) versus 0.47 (0.33; 0.71) ng/L, p < 0.0001]. The 99th percentile of cTnI was 15.79 ng/L in men and 5.11 ng/L in women. Out of 46 variables, 22 independent determinants for cTnI were identified. The strongest associations were observed with sex, age, systolic blood pressure, heart rate, left ventricular mass, N-terminal pro B-type natriuretic peptide, and creatine kinase (all p < 0.0001). The final model explained 36 % of the overall cTnI variability. Heritability of cTnI was estimated to be 29 % (p = 0.005), but became non-significant when the residuals of the multivariable model were used for analysis (5 %, p = 0.36). CONCLUSIONS: Sex, age, and systolic blood pressure belong to the strongest determinants of hs-cTnI in healthy adults. The 99th percentile was three times higher in men compared to women. Hence, sex-specific cut-off values may be preferable when applying hs-cTnI for screening purposes. Our results may also improve the interpretation of cTn levels in daily clinical practice. More... »

PAGES

96-104

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00392-016-1026-5

DOI

http://dx.doi.org/10.1007/s00392-016-1026-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1045438766

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27535138


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