Drug-coated balloons for treatment of coronary artery disease: updated recommendations from a consensus group View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-11

AUTHORS

Franz X. Kleber, Harald Rittger, Klaus Bonaventura, Uwe Zeymer, Jochen Wöhrle, Raban Jeger, Benny Levenson, Sven Möbius-Winkler, Leonhard Bruch, Dieter Fischer, Christian Hengstenberg, Tudor Pörner, Detlef Mathey, Bruno Scheller

ABSTRACT

AIMS: Drug-coated balloon catheters (DCB) are a new clinical treatment modality for coronary and peripheral artery disease. The goal of the consensus group is to develop recommendations for the clinical use of DCB based on randomized clinical trials and the best available clinical evidence. The present paper gives an update on the recommendations against the background of a variety of new data published since the first paper was presented. METHODS AND RESULTS: The general concept of our recommendations for the coronary use of DCB includes the preparation of the lesion to facilitate drug delivery and to estimate the need for stent implantation, especially after relevant dissections. Lesion preparation includes conventional angioplasty. In more complex lesions, additional treatments and imaging or functional measurements are helpful. In case of no flow-limiting dissection and an acceptable but not stent-like primary result, DCB use without additional stent implantation may be considered. The proposed advantages of the DCB only concept over a direct stent approach include reduced restenosis rates in indications where DES show limited efficacy, the reduction of DAPT especially in patients with contraindications for prolonged DAPT, and the option of leaving no foreign object behind resulting in vascular restoration with potentially plaque regression instead of neo-atherosclerosis. CONCLUSIONS: DCB allow for local drug delivery in endovascular therapy leaving no permanent implant behind. More... »

PAGES

785-797

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00392-013-0609-7

DOI

http://dx.doi.org/10.1007/s00392-013-0609-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029221695

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23982467


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