Morphological and functional adaptation of the small intestine after colectomy and ileal pouch-anal anastomosis in rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11-17

AUTHORS

Stefan Willis, Kai Kisielinski, Bernd Klosterhalfen, Volker Schumpelick

ABSTRACT

.Background and aims: This study investigated morphological and functional changes in the small bowel after colectomy and ileal pouch-anal anastomosis (IPAA). Methods and materials: In 15 rats electrolyte, glucose, and water absorption was determined by in vivo single-pass perfusion of the proximal and distal small intestine 15 weeks after IPAA. Afterwards the small intestine was resected for morphometric evaluation. Controls were 15 identically treated rats without operation. Results: IPAA led to a significant increase in the small intestinal diameter and a significant increase in villus length and density, which was more apparent in ileum than in jejunum. Therefore the mucosal surface per unit serosa increased significantly by 59% in the jejunum and by 76% in the ileum. In the pouch there was a significant increase in goblet cell density, crypt depth, and diameter of the muscularis which was not detectable in the segments proximal from the pouch. Due to the increase in mucosal surface there was a significant increase in total glucose and electrolyte absorption in the ileum while absorption rates per unit mucosa were unchanged, with the exception of an increase in mucosal sodium absorption. Jejunal absorption and ileal absorption of water remained unchanged. Conclusion: Adaptation of the small intestine after IPAA leads to colonic metaplasia in the pouch and intestinal hyperplasia proximal from the pouch. The loss of colonic absorption is compensated by the increase in ileal mucosal surface with subsequently elevated electrolyte and glucose absorption. Changes in intestinal permeability may be responsible for additional water depletion, which is compensated by the upregulation of enteric water and sodium absorption. More... »

PAGES

85-91

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s003840100352

DOI

http://dx.doi.org/10.1007/s003840100352

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026244508

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12014426


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptation, Physiological", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonic Pouches", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ileum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Absorption", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Jejunum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany", 
          "id": "http://www.grid.ac/institutes/grid.1957.a", 
          "name": [
            "Department of Surgery, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Willis", 
        "givenName": "Stefan", 
        "id": "sg:person.01106405176.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106405176.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany", 
          "id": "http://www.grid.ac/institutes/grid.1957.a", 
          "name": [
            "Department of Surgery, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kisielinski", 
        "givenName": "Kai", 
        "id": "sg:person.01167300426.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167300426.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Pathology, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany", 
          "id": "http://www.grid.ac/institutes/grid.1957.a", 
          "name": [
            "Institute of Pathology, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Klosterhalfen", 
        "givenName": "Bernd", 
        "id": "sg:person.010743050164.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010743050164.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany", 
          "id": "http://www.grid.ac/institutes/grid.1957.a", 
          "name": [
            "Department of Surgery, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schumpelick", 
        "givenName": "Volker", 
        "id": "sg:person.0617257550.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617257550.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/bf01656599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039726392", 
          "https://doi.org/10.1007/bf01656599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00337584", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030575298", 
          "https://doi.org/10.1007/bf00337584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01312224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024058813", 
          "https://doi.org/10.1007/bf01312224"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2001-11-17", 
    "datePublishedReg": "2001-11-17", 
    "description": "Abstract.Background and aims: This study investigated morphological and functional changes in the small bowel after colectomy and ileal pouch-anal anastomosis (IPAA). Methods and materials: In 15 rats electrolyte, glucose, and water absorption was determined by in vivo single-pass perfusion of the proximal and distal small intestine 15\u00a0weeks after IPAA. Afterwards the small intestine was resected for morphometric evaluation. Controls were 15 identically treated rats without operation. Results: IPAA led to a significant increase in the small intestinal diameter and a significant increase in villus length and density, which was more apparent in ileum than in jejunum. Therefore the mucosal surface per unit serosa increased significantly by 59% in the jejunum and by 76% in the ileum. In the pouch there was a significant increase in goblet cell density, crypt depth, and diameter of the muscularis which was not detectable in the segments proximal from the pouch. Due to the increase in mucosal surface there was a significant increase in total glucose and electrolyte absorption in the ileum while absorption rates per unit mucosa were unchanged, with the exception of an increase in mucosal sodium absorption. Jejunal absorption and ileal absorption of water remained unchanged. Conclusion: Adaptation of the small intestine after IPAA leads to colonic metaplasia in the pouch and intestinal hyperplasia proximal from the pouch. The loss of colonic absorption is compensated by the increase in ileal mucosal surface with subsequently elevated electrolyte and glucose absorption. Changes in intestinal permeability may be responsible for additional water depletion, which is compensated by the upregulation of enteric water and sodium absorption.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s003840100352", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096381", 
        "issn": [
          "0179-1958", 
          "1432-1262"
        ], 
        "name": "International Journal of Colorectal Disease", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "17"
      }
    ], 
    "keywords": [
      "pouch-anal anastomosis", 
      "mucosal surfaces", 
      "small intestine", 
      "significant increase", 
      "small intestinal diameter", 
      "sodium absorption", 
      "goblet cell density", 
      "single-pass perfusion", 
      "colonic metaplasia", 
      "intestinal diameter", 
      "small bowel", 
      "villus length", 
      "intestinal permeability", 
      "crypt depth", 
      "morphometric evaluation", 
      "glucose absorption", 
      "ileal absorption", 
      "jejunal absorption", 
      "functional changes", 
      "IPAA", 
      "rats", 
      "ileum", 
      "electrolyte absorption", 
      "colonic absorption", 
      "colectomy", 
      "intestine", 
      "anastomosis", 
      "jejunum", 
      "pouch", 
      "functional adaptation", 
      "total glucose", 
      "glucose", 
      "bowel", 
      "metaplasia", 
      "cell density", 
      "perfusion", 
      "mucosa", 
      "muscularis", 
      "increase", 
      "serosa", 
      "weeks", 
      "upregulation", 
      "proximal", 
      "changes", 
      "absorption rate", 
      "depletion", 
      "control", 
      "study", 
      "evaluation", 
      "background", 
      "rate", 
      "diameter", 
      "loss", 
      "adaptation", 
      "segments", 
      "exception", 
      "absorption", 
      "permeability", 
      "length", 
      "method", 
      "operation", 
      "density", 
      "materials", 
      "surface", 
      "depth", 
      "water", 
      "water depletion", 
      "electrolyte", 
      "water absorption", 
      "vivo single-pass perfusion", 
      "distal small intestine 15", 
      "small intestine 15", 
      "intestine 15", 
      "unit serosa", 
      "unit mucosa", 
      "mucosal sodium absorption", 
      "intestinal hyperplasia proximal", 
      "hyperplasia proximal", 
      "ileal mucosal surface", 
      "elevated electrolyte", 
      "additional water depletion", 
      "enteric water"
    ], 
    "name": "Morphological and functional adaptation of the small intestine after colectomy and ileal pouch-anal anastomosis in rats", 
    "pagination": "85-91", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1026244508"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s003840100352"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "12014426"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s003840100352", 
      "https://app.dimensions.ai/details/publication/pub.1026244508"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_315.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s003840100352"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s003840100352'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s003840100352'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s003840100352'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s003840100352'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      22 PREDICATES      123 URIs      112 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s003840100352 schema:about N062352c794504a708f7e2a824fa5d6a1
2 N097bafc7b19a4454ab57f955e7755dac
3 N19dd90dada77469aa3a79bc70a39b1d0
4 N39833337a132461591f0788d7f4f04cb
5 N6efafdc6e7984e05b2bb0048887ef86e
6 N7545a576a837484891d3b243ca6598c4
7 N8dbff19fa0f0473989bd3450104e193d
8 N91d839241bac4383a6bca2e736714a1b
9 N9433c72c64344dc8875a1bfd4240e125
10 Ndc3ed79c4f1d43ecbff8ca516ad9e825
11 Ne3fa63a8cfe942819adbaaf861180da4
12 Nff8e00499daf4f49bb3cb18d2bbf88f3
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author N8882900158f04d4e8dee52da9b9deccb
16 schema:citation sg:pub.10.1007/bf00337584
17 sg:pub.10.1007/bf01312224
18 sg:pub.10.1007/bf01656599
19 schema:datePublished 2001-11-17
20 schema:datePublishedReg 2001-11-17
21 schema:description Abstract.Background and aims: This study investigated morphological and functional changes in the small bowel after colectomy and ileal pouch-anal anastomosis (IPAA). Methods and materials: In 15 rats electrolyte, glucose, and water absorption was determined by in vivo single-pass perfusion of the proximal and distal small intestine 15 weeks after IPAA. Afterwards the small intestine was resected for morphometric evaluation. Controls were 15 identically treated rats without operation. Results: IPAA led to a significant increase in the small intestinal diameter and a significant increase in villus length and density, which was more apparent in ileum than in jejunum. Therefore the mucosal surface per unit serosa increased significantly by 59% in the jejunum and by 76% in the ileum. In the pouch there was a significant increase in goblet cell density, crypt depth, and diameter of the muscularis which was not detectable in the segments proximal from the pouch. Due to the increase in mucosal surface there was a significant increase in total glucose and electrolyte absorption in the ileum while absorption rates per unit mucosa were unchanged, with the exception of an increase in mucosal sodium absorption. Jejunal absorption and ileal absorption of water remained unchanged. Conclusion: Adaptation of the small intestine after IPAA leads to colonic metaplasia in the pouch and intestinal hyperplasia proximal from the pouch. The loss of colonic absorption is compensated by the increase in ileal mucosal surface with subsequently elevated electrolyte and glucose absorption. Changes in intestinal permeability may be responsible for additional water depletion, which is compensated by the upregulation of enteric water and sodium absorption.
22 schema:genre article
23 schema:inLanguage en
24 schema:isAccessibleForFree false
25 schema:isPartOf N65ea1b856e144bcca8ffe2f3c99e910d
26 Nd0ab75cd238446b0afac580562b80d32
27 sg:journal.1096381
28 schema:keywords IPAA
29 absorption
30 absorption rate
31 adaptation
32 additional water depletion
33 anastomosis
34 background
35 bowel
36 cell density
37 changes
38 colectomy
39 colonic absorption
40 colonic metaplasia
41 control
42 crypt depth
43 density
44 depletion
45 depth
46 diameter
47 distal small intestine 15
48 electrolyte
49 electrolyte absorption
50 elevated electrolyte
51 enteric water
52 evaluation
53 exception
54 functional adaptation
55 functional changes
56 glucose
57 glucose absorption
58 goblet cell density
59 hyperplasia proximal
60 ileal absorption
61 ileal mucosal surface
62 ileum
63 increase
64 intestinal diameter
65 intestinal hyperplasia proximal
66 intestinal permeability
67 intestine
68 intestine 15
69 jejunal absorption
70 jejunum
71 length
72 loss
73 materials
74 metaplasia
75 method
76 morphometric evaluation
77 mucosa
78 mucosal sodium absorption
79 mucosal surfaces
80 muscularis
81 operation
82 perfusion
83 permeability
84 pouch
85 pouch-anal anastomosis
86 proximal
87 rate
88 rats
89 segments
90 serosa
91 significant increase
92 single-pass perfusion
93 small bowel
94 small intestinal diameter
95 small intestine
96 small intestine 15
97 sodium absorption
98 study
99 surface
100 total glucose
101 unit mucosa
102 unit serosa
103 upregulation
104 villus length
105 vivo single-pass perfusion
106 water
107 water absorption
108 water depletion
109 weeks
110 schema:name Morphological and functional adaptation of the small intestine after colectomy and ileal pouch-anal anastomosis in rats
111 schema:pagination 85-91
112 schema:productId N0a889320736d44d3bd90c9a6aeea31f9
113 N11eae5818a1242efb17e97823ac0b24b
114 Ned05149eaebd458fa0f13a983ce62620
115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026244508
116 https://doi.org/10.1007/s003840100352
117 schema:sdDatePublished 2022-01-01T18:10
118 schema:sdLicense https://scigraph.springernature.com/explorer/license/
119 schema:sdPublisher Ne03fd09ca7224ae9b515809f78b560e1
120 schema:url https://doi.org/10.1007/s003840100352
121 sgo:license sg:explorer/license/
122 sgo:sdDataset articles
123 rdf:type schema:ScholarlyArticle
124 N062352c794504a708f7e2a824fa5d6a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Colectomy
126 rdf:type schema:DefinedTerm
127 N097bafc7b19a4454ab57f955e7755dac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Intestines
129 rdf:type schema:DefinedTerm
130 N0a889320736d44d3bd90c9a6aeea31f9 schema:name doi
131 schema:value 10.1007/s003840100352
132 rdf:type schema:PropertyValue
133 N11eae5818a1242efb17e97823ac0b24b schema:name dimensions_id
134 schema:value pub.1026244508
135 rdf:type schema:PropertyValue
136 N19dd90dada77469aa3a79bc70a39b1d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Colonic Pouches
138 rdf:type schema:DefinedTerm
139 N1efa90d2ac4641698b9949217fe37e98 rdf:first sg:person.010743050164.68
140 rdf:rest Nbd7f114495a245dd95868c9793e18375
141 N39833337a132461591f0788d7f4f04cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Male
143 rdf:type schema:DefinedTerm
144 N65ea1b856e144bcca8ffe2f3c99e910d schema:issueNumber 2
145 rdf:type schema:PublicationIssue
146 N6efafdc6e7984e05b2bb0048887ef86e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Intestinal Mucosa
148 rdf:type schema:DefinedTerm
149 N7545a576a837484891d3b243ca6598c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Intestinal Absorption
151 rdf:type schema:DefinedTerm
152 N8882900158f04d4e8dee52da9b9deccb rdf:first sg:person.01106405176.67
153 rdf:rest Ne7d6fb799bee4b51a9623e98c4a47abb
154 N8dbff19fa0f0473989bd3450104e193d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Jejunum
156 rdf:type schema:DefinedTerm
157 N91d839241bac4383a6bca2e736714a1b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Rats, Wistar
159 rdf:type schema:DefinedTerm
160 N9433c72c64344dc8875a1bfd4240e125 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Rats
162 rdf:type schema:DefinedTerm
163 Nbd7f114495a245dd95868c9793e18375 rdf:first sg:person.0617257550.39
164 rdf:rest rdf:nil
165 Nd0ab75cd238446b0afac580562b80d32 schema:volumeNumber 17
166 rdf:type schema:PublicationVolume
167 Ndc3ed79c4f1d43ecbff8ca516ad9e825 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Ileum
169 rdf:type schema:DefinedTerm
170 Ne03fd09ca7224ae9b515809f78b560e1 schema:name Springer Nature - SN SciGraph project
171 rdf:type schema:Organization
172 Ne3fa63a8cfe942819adbaaf861180da4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Animals
174 rdf:type schema:DefinedTerm
175 Ne7d6fb799bee4b51a9623e98c4a47abb rdf:first sg:person.01167300426.38
176 rdf:rest N1efa90d2ac4641698b9949217fe37e98
177 Ned05149eaebd458fa0f13a983ce62620 schema:name pubmed_id
178 schema:value 12014426
179 rdf:type schema:PropertyValue
180 Nff8e00499daf4f49bb3cb18d2bbf88f3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Adaptation, Physiological
182 rdf:type schema:DefinedTerm
183 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
184 schema:name Medical and Health Sciences
185 rdf:type schema:DefinedTerm
186 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
187 schema:name Clinical Sciences
188 rdf:type schema:DefinedTerm
189 sg:journal.1096381 schema:issn 0179-1958
190 1432-1262
191 schema:name International Journal of Colorectal Disease
192 schema:publisher Springer Nature
193 rdf:type schema:Periodical
194 sg:person.010743050164.68 schema:affiliation grid-institutes:grid.1957.a
195 schema:familyName Klosterhalfen
196 schema:givenName Bernd
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010743050164.68
198 rdf:type schema:Person
199 sg:person.01106405176.67 schema:affiliation grid-institutes:grid.1957.a
200 schema:familyName Willis
201 schema:givenName Stefan
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106405176.67
203 rdf:type schema:Person
204 sg:person.01167300426.38 schema:affiliation grid-institutes:grid.1957.a
205 schema:familyName Kisielinski
206 schema:givenName Kai
207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01167300426.38
208 rdf:type schema:Person
209 sg:person.0617257550.39 schema:affiliation grid-institutes:grid.1957.a
210 schema:familyName Schumpelick
211 schema:givenName Volker
212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617257550.39
213 rdf:type schema:Person
214 sg:pub.10.1007/bf00337584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030575298
215 https://doi.org/10.1007/bf00337584
216 rdf:type schema:CreativeWork
217 sg:pub.10.1007/bf01312224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024058813
218 https://doi.org/10.1007/bf01312224
219 rdf:type schema:CreativeWork
220 sg:pub.10.1007/bf01656599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039726392
221 https://doi.org/10.1007/bf01656599
222 rdf:type schema:CreativeWork
223 grid-institutes:grid.1957.a schema:alternateName Department of Surgery, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany
224 Institute of Pathology, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany
225 schema:name Department of Surgery, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany
226 Institute of Pathology, Technical University Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany, Germany
227 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...