Relapse rates after withdrawal of thiopurines in patients with inflammatory bowel disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-07-14

AUTHORS

Mukesh Kumar Ranjan, Sudheer Kumar Vuyyuru, Bhaskar Kante, Peeyush Kumar, Sandeep K. Mundhra, Rithvik Golla, Raju Sharma, Peush Sahni, Prasenjit Das, Govind Makharia, Saurabh Kedia, Vineet Ahuja

ABSTRACT

PurposeWithdrawal of thiopurines after remission is associated with an increased risk of relapse in patients with inflammatory bowel disease (IBD). However, long-term data on thiopurine withdrawal is limited, especially from developing countries where the cost of long-term therapy poses a significant burden on patients.MethodsPatients with IBD on thiopurine monotherapy for ≥ 4 months, who stopped thiopurines while in clinical remission and were not on any other immunomodulator or biologics at the time of withdrawal, were included in this retrospective analysis.ResultsAmong 1093 patients with IBD on thiopurine monotherapy, 461 patients stopped thiopurine due to various reasons. Among these, 218 (ulcerative colitis (UC) = 179; Crohn’s disease (CD) = 39) patients were in clinical remission and were continued on mesalamine. Overall, 36.7% (n = 80) relapsed after a median duration of 20 months (IQR: 9–49). Relapse rate was higher in UC than CD (39.7% vs 23%, p = 0.055). Cumulative probabilities of relapse were 17%, 34%, and 44% at the end of 1, 3, and 5 years, respectively. The relapse rate at 5 years was significantly lower in patients who had stopped azathioprine after 4 years of therapy (31% vs 54%, p = 0.007). On multi-variate cox regression analysis, male sex [HR: 1.6(1.0–2.6), p = 0.02] and short duration of therapy with thiopurines [HR: 1.02 (1.01–1.02), p = 0.004] before withdrawal were associated with increased risk of relapse.ConclusionApproximately 50% patients with IBD in remission would relapse after 5 years of thiopurine withdrawal. Male sex and shorter treatment duration predict relapse. Treatment should be continued in patients who tolerate and maintain remission on long-term thiopurine. More... »

PAGES

1817-1826

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00384-022-04216-5

DOI

http://dx.doi.org/10.1007/s00384-022-04216-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1149471877

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35835862


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Azathioprine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colitis, Ulcerative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Crohn Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunologic Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunosuppressive Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammatory Bowel Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ranjan", 
        "givenName": "Mukesh Kumar", 
        "id": "sg:person.016136305075.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016136305075.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vuyyuru", 
        "givenName": "Sudheer Kumar", 
        "id": "sg:person.013263022266.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013263022266.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kante", 
        "givenName": "Bhaskar", 
        "id": "sg:person.012516413241.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012516413241.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kumar", 
        "givenName": "Peeyush", 
        "id": "sg:person.010463211735.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010463211735.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mundhra", 
        "givenName": "Sandeep K.", 
        "id": "sg:person.016570721452.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016570721452.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Golla", 
        "givenName": "Rithvik", 
        "id": "sg:person.012415243213.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012415243213.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Radio Diagnosis, All India Institute of Medical Sciences, New Delhi, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Radio Diagnosis, All India Institute of Medical Sciences, New Delhi, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sharma", 
        "givenName": "Raju", 
        "id": "sg:person.01050273610.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050273610.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastrointestinal Surgery, All India Institute of Medical Sciences, New Delhi, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Gastrointestinal Surgery, All India Institute of Medical Sciences, New Delhi, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sahni", 
        "givenName": "Peush", 
        "id": "sg:person.01127261411.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127261411.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, All India Institute of Medical Sciences, New Delhi, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Das", 
        "givenName": "Prasenjit", 
        "id": "sg:person.01222677142.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222677142.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Makharia", 
        "givenName": "Govind", 
        "id": "sg:person.0671743447.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671743447.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kedia", 
        "givenName": "Saurabh", 
        "id": "sg:person.01361506206.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361506206.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India", 
          "id": "http://www.grid.ac/institutes/grid.413618.9", 
          "name": [
            "Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ahuja", 
        "givenName": "Vineet", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10620-014-3419-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015177562", 
          "https://doi.org/10.1007/s10620-014-3419-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ajg.2009.410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015352204", 
          "https://doi.org/10.1038/ajg.2009.410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-003-1139-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052421926", 
          "https://doi.org/10.1007/s00535-003-1139-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41575-020-00360-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1131495195", 
          "https://doi.org/10.1038/s41575-020-00360-x"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2022-07-14", 
    "datePublishedReg": "2022-07-14", 
    "description": "Abstract\nPurposeWithdrawal of thiopurines after remission is associated with an increased risk of relapse in patients with inflammatory bowel disease (IBD). However, long-term data on thiopurine withdrawal is limited, especially from developing countries where the cost of long-term therapy poses a significant burden on patients.MethodsPatients with IBD on thiopurine monotherapy for\u2009\u2265\u20094\u00a0months, who stopped thiopurines while in clinical remission and were not on any other immunomodulator or biologics at the time of withdrawal, were included in this retrospective analysis.ResultsAmong 1093 patients with IBD on thiopurine monotherapy, 461 patients stopped thiopurine due to various reasons. Among these, 218 (ulcerative colitis (UC)\u2009=\u2009179; Crohn\u2019s disease (CD)\u2009=\u200939) patients were in clinical remission and were continued on mesalamine. Overall, 36.7% (n\u2009=\u200980) relapsed after a median duration of 20\u00a0months (IQR: 9\u201349). Relapse rate was higher in UC than CD (39.7% vs 23%, p\u2009=\u20090.055). Cumulative probabilities of relapse were 17%, 34%, and 44% at the end of 1, 3, and 5\u00a0years, respectively. The relapse rate at 5\u00a0years was significantly lower in patients who had stopped azathioprine after 4\u00a0years of therapy (31% vs 54%, p\u2009=\u20090.007). On multi-variate cox regression analysis, male sex [HR: 1.6(1.0\u20132.6), p\u2009=\u20090.02] and short duration of therapy with thiopurines [HR: 1.02 (1.01\u20131.02), p\u2009=\u20090.004] before withdrawal were associated with increased risk of relapse.ConclusionApproximately 50% patients with IBD in remission would relapse after 5\u00a0years of thiopurine withdrawal. Male sex and shorter treatment duration predict relapse. Treatment should be continued in patients who tolerate and maintain remission on long-term thiopurine.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00384-022-04216-5", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096381", 
        "issn": [
          "0179-1958", 
          "1432-1262"
        ], 
        "name": "International Journal of Colorectal Disease", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "keywords": [
      "inflammatory bowel disease", 
      "risk of relapse", 
      "relapse rate", 
      "thiopurine monotherapy", 
      "clinical remission", 
      "bowel disease", 
      "male sex", 
      "thiopurine withdrawal", 
      "multi-variate Cox regression analysis", 
      "years of therapy", 
      "long-term therapy", 
      "Cox regression analysis", 
      "shorter treatment duration", 
      "time of withdrawal", 
      "median duration", 
      "retrospective analysis", 
      "remission", 
      "patients", 
      "treatment duration", 
      "thiopurines", 
      "significant burden", 
      "relapse", 
      "therapy", 
      "cumulative probability", 
      "monotherapy", 
      "withdrawal", 
      "regression analysis", 
      "short duration", 
      "long-term data", 
      "disease", 
      "months", 
      "duration", 
      "sex", 
      "risk", 
      "years", 
      "MethodsPatients", 
      "immunomodulators", 
      "mesalamine", 
      "biologics", 
      "rate", 
      "treatment", 
      "burden", 
      "UC", 
      "analysis", 
      "data", 
      "reasons", 
      "time", 
      "end", 
      "countries", 
      "probability", 
      "cost", 
      "Cd"
    ], 
    "name": "Relapse rates after withdrawal of thiopurines in patients with inflammatory bowel disease", 
    "pagination": "1817-1826", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1149471877"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00384-022-04216-5"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "35835862"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00384-022-04216-5", 
      "https://app.dimensions.ai/details/publication/pub.1149471877"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-09-02T16:07", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/article/article_932.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00384-022-04216-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00384-022-04216-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00384-022-04216-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00384-022-04216-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00384-022-04216-5'


 

This table displays all metadata directly associated to this object as RDF triples.

251 TRIPLES      21 PREDICATES      91 URIs      79 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00384-022-04216-5 schema:about N279dc6590cd8484ea8588b78dd5e62c1
2 N2b76950a6ef142fe8d45ea8af34b78a8
3 N5685b57f375b4940b3cd9560c1d2bf23
4 N87c1f56deda34dcf95de2d03c05ca661
5 N8c6498ab616d4c15a33f5d6288e77a25
6 N8dacd2067b854dde809427e9d0e9d63a
7 N92f0ba0393e84c6aa2835928e973e853
8 N971a12737f614cdab604358c1277c122
9 Nda69d609b3b4411094c6060ba0b9b7c4
10 Nf9ebb34dbd4c4f489e9cd95ca38e6a4f
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author Nc24d3db37c7e48149d4262d5861c68c0
14 schema:citation sg:pub.10.1007/s00535-003-1139-2
15 sg:pub.10.1007/s10620-014-3419-5
16 sg:pub.10.1038/ajg.2009.410
17 sg:pub.10.1038/s41575-020-00360-x
18 schema:datePublished 2022-07-14
19 schema:datePublishedReg 2022-07-14
20 schema:description Abstract PurposeWithdrawal of thiopurines after remission is associated with an increased risk of relapse in patients with inflammatory bowel disease (IBD). However, long-term data on thiopurine withdrawal is limited, especially from developing countries where the cost of long-term therapy poses a significant burden on patients.MethodsPatients with IBD on thiopurine monotherapy for ≥ 4 months, who stopped thiopurines while in clinical remission and were not on any other immunomodulator or biologics at the time of withdrawal, were included in this retrospective analysis.ResultsAmong 1093 patients with IBD on thiopurine monotherapy, 461 patients stopped thiopurine due to various reasons. Among these, 218 (ulcerative colitis (UC) = 179; Crohn’s disease (CD) = 39) patients were in clinical remission and were continued on mesalamine. Overall, 36.7% (n = 80) relapsed after a median duration of 20 months (IQR: 9–49). Relapse rate was higher in UC than CD (39.7% vs 23%, p = 0.055). Cumulative probabilities of relapse were 17%, 34%, and 44% at the end of 1, 3, and 5 years, respectively. The relapse rate at 5 years was significantly lower in patients who had stopped azathioprine after 4 years of therapy (31% vs 54%, p = 0.007). On multi-variate cox regression analysis, male sex [HR: 1.6(1.0–2.6), p = 0.02] and short duration of therapy with thiopurines [HR: 1.02 (1.01–1.02), p = 0.004] before withdrawal were associated with increased risk of relapse.ConclusionApproximately 50% patients with IBD in remission would relapse after 5 years of thiopurine withdrawal. Male sex and shorter treatment duration predict relapse. Treatment should be continued in patients who tolerate and maintain remission on long-term thiopurine.
21 schema:genre article
22 schema:isAccessibleForFree false
23 schema:isPartOf N05408155e80648d78ccbfce6cbdd887b
24 Nc4f5e95bc3e1489fb12216aba8cd0fd0
25 sg:journal.1096381
26 schema:keywords Cd
27 Cox regression analysis
28 MethodsPatients
29 UC
30 analysis
31 biologics
32 bowel disease
33 burden
34 clinical remission
35 cost
36 countries
37 cumulative probability
38 data
39 disease
40 duration
41 end
42 immunomodulators
43 inflammatory bowel disease
44 long-term data
45 long-term therapy
46 male sex
47 median duration
48 mesalamine
49 monotherapy
50 months
51 multi-variate Cox regression analysis
52 patients
53 probability
54 rate
55 reasons
56 regression analysis
57 relapse
58 relapse rate
59 remission
60 retrospective analysis
61 risk
62 risk of relapse
63 sex
64 short duration
65 shorter treatment duration
66 significant burden
67 therapy
68 thiopurine monotherapy
69 thiopurine withdrawal
70 thiopurines
71 time
72 time of withdrawal
73 treatment
74 treatment duration
75 withdrawal
76 years
77 years of therapy
78 schema:name Relapse rates after withdrawal of thiopurines in patients with inflammatory bowel disease
79 schema:pagination 1817-1826
80 schema:productId N385a8df3aae348be83a77b7816d37b11
81 Nc36242c7cfce4369954df233a7c86cb4
82 Ne4d2ffb9287e45539520af09eae2c637
83 schema:sameAs https://app.dimensions.ai/details/publication/pub.1149471877
84 https://doi.org/10.1007/s00384-022-04216-5
85 schema:sdDatePublished 2022-09-02T16:07
86 schema:sdLicense https://scigraph.springernature.com/explorer/license/
87 schema:sdPublisher Ncc30d7864c04449b809140e6192cf583
88 schema:url https://doi.org/10.1007/s00384-022-04216-5
89 sgo:license sg:explorer/license/
90 sgo:sdDataset articles
91 rdf:type schema:ScholarlyArticle
92 N05408155e80648d78ccbfce6cbdd887b schema:issueNumber 8
93 rdf:type schema:PublicationIssue
94 N241c926f52ec4684b75dcfd67f959a88 rdf:first sg:person.01050273610.63
95 rdf:rest Naf6468f9068c4444a69e6d2d23940bd4
96 N279dc6590cd8484ea8588b78dd5e62c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Recurrence
98 rdf:type schema:DefinedTerm
99 N2a9b6439432d4fb89c3334ae8567fe78 rdf:first sg:person.01361506206.65
100 rdf:rest N9779f00e3ddc416982282aafa60bb56d
101 N2b76950a6ef142fe8d45ea8af34b78a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Immunologic Factors
103 rdf:type schema:DefinedTerm
104 N36baa2d35bab4398903acc98c3d38aab rdf:first sg:person.010463211735.19
105 rdf:rest Nd18791936e8e4773aeee61f31f372ffb
106 N385a8df3aae348be83a77b7816d37b11 schema:name pubmed_id
107 schema:value 35835862
108 rdf:type schema:PropertyValue
109 N5685b57f375b4940b3cd9560c1d2bf23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Immunosuppressive Agents
111 rdf:type schema:DefinedTerm
112 N589ad3465c8d4a6eab3953b96be2aa91 rdf:first sg:person.013263022266.98
113 rdf:rest N5d0056ebd2c042d380d8e474b6ef4e43
114 N5d0056ebd2c042d380d8e474b6ef4e43 rdf:first sg:person.012516413241.20
115 rdf:rest N36baa2d35bab4398903acc98c3d38aab
116 N5f8e813855404ca18fb5251705993742 rdf:first sg:person.0671743447.19
117 rdf:rest N2a9b6439432d4fb89c3334ae8567fe78
118 N73f142a55c6742e6abd232a55e532c19 rdf:first sg:person.012415243213.16
119 rdf:rest N241c926f52ec4684b75dcfd67f959a88
120 N83d018a8e2234716ab2b19eba6209be7 schema:affiliation grid-institutes:grid.413618.9
121 schema:familyName Ahuja
122 schema:givenName Vineet
123 rdf:type schema:Person
124 N87c1f56deda34dcf95de2d03c05ca661 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Humans
126 rdf:type schema:DefinedTerm
127 N8c6498ab616d4c15a33f5d6288e77a25 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Azathioprine
129 rdf:type schema:DefinedTerm
130 N8dacd2067b854dde809427e9d0e9d63a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Crohn Disease
132 rdf:type schema:DefinedTerm
133 N92f0ba0393e84c6aa2835928e973e853 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Inflammatory Bowel Diseases
135 rdf:type schema:DefinedTerm
136 N971a12737f614cdab604358c1277c122 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Retrospective Studies
138 rdf:type schema:DefinedTerm
139 N9779f00e3ddc416982282aafa60bb56d rdf:first N83d018a8e2234716ab2b19eba6209be7
140 rdf:rest rdf:nil
141 Naf6468f9068c4444a69e6d2d23940bd4 rdf:first sg:person.01127261411.15
142 rdf:rest Nc61d6c9de9ce4863b0af8d61c931058c
143 Nc24d3db37c7e48149d4262d5861c68c0 rdf:first sg:person.016136305075.18
144 rdf:rest N589ad3465c8d4a6eab3953b96be2aa91
145 Nc36242c7cfce4369954df233a7c86cb4 schema:name dimensions_id
146 schema:value pub.1149471877
147 rdf:type schema:PropertyValue
148 Nc4f5e95bc3e1489fb12216aba8cd0fd0 schema:volumeNumber 37
149 rdf:type schema:PublicationVolume
150 Nc61d6c9de9ce4863b0af8d61c931058c rdf:first sg:person.01222677142.75
151 rdf:rest N5f8e813855404ca18fb5251705993742
152 Ncc30d7864c04449b809140e6192cf583 schema:name Springer Nature - SN SciGraph project
153 rdf:type schema:Organization
154 Nd18791936e8e4773aeee61f31f372ffb rdf:first sg:person.016570721452.59
155 rdf:rest N73f142a55c6742e6abd232a55e532c19
156 Nda69d609b3b4411094c6060ba0b9b7c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Colitis, Ulcerative
158 rdf:type schema:DefinedTerm
159 Ne4d2ffb9287e45539520af09eae2c637 schema:name doi
160 schema:value 10.1007/s00384-022-04216-5
161 rdf:type schema:PropertyValue
162 Nf9ebb34dbd4c4f489e9cd95ca38e6a4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Male
164 rdf:type schema:DefinedTerm
165 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
166 schema:name Medical and Health Sciences
167 rdf:type schema:DefinedTerm
168 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
169 schema:name Clinical Sciences
170 rdf:type schema:DefinedTerm
171 sg:journal.1096381 schema:issn 0179-1958
172 1432-1262
173 schema:name International Journal of Colorectal Disease
174 schema:publisher Springer Nature
175 rdf:type schema:Periodical
176 sg:person.010463211735.19 schema:affiliation grid-institutes:grid.413618.9
177 schema:familyName Kumar
178 schema:givenName Peeyush
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010463211735.19
180 rdf:type schema:Person
181 sg:person.01050273610.63 schema:affiliation grid-institutes:grid.413618.9
182 schema:familyName Sharma
183 schema:givenName Raju
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01050273610.63
185 rdf:type schema:Person
186 sg:person.01127261411.15 schema:affiliation grid-institutes:grid.413618.9
187 schema:familyName Sahni
188 schema:givenName Peush
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127261411.15
190 rdf:type schema:Person
191 sg:person.01222677142.75 schema:affiliation grid-institutes:grid.413618.9
192 schema:familyName Das
193 schema:givenName Prasenjit
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01222677142.75
195 rdf:type schema:Person
196 sg:person.012415243213.16 schema:affiliation grid-institutes:grid.413618.9
197 schema:familyName Golla
198 schema:givenName Rithvik
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012415243213.16
200 rdf:type schema:Person
201 sg:person.012516413241.20 schema:affiliation grid-institutes:grid.413618.9
202 schema:familyName Kante
203 schema:givenName Bhaskar
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012516413241.20
205 rdf:type schema:Person
206 sg:person.013263022266.98 schema:affiliation grid-institutes:grid.413618.9
207 schema:familyName Vuyyuru
208 schema:givenName Sudheer Kumar
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013263022266.98
210 rdf:type schema:Person
211 sg:person.01361506206.65 schema:affiliation grid-institutes:grid.413618.9
212 schema:familyName Kedia
213 schema:givenName Saurabh
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361506206.65
215 rdf:type schema:Person
216 sg:person.016136305075.18 schema:affiliation grid-institutes:grid.413618.9
217 schema:familyName Ranjan
218 schema:givenName Mukesh Kumar
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016136305075.18
220 rdf:type schema:Person
221 sg:person.016570721452.59 schema:affiliation grid-institutes:grid.413618.9
222 schema:familyName Mundhra
223 schema:givenName Sandeep K.
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016570721452.59
225 rdf:type schema:Person
226 sg:person.0671743447.19 schema:affiliation grid-institutes:grid.413618.9
227 schema:familyName Makharia
228 schema:givenName Govind
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671743447.19
230 rdf:type schema:Person
231 sg:pub.10.1007/s00535-003-1139-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052421926
232 https://doi.org/10.1007/s00535-003-1139-2
233 rdf:type schema:CreativeWork
234 sg:pub.10.1007/s10620-014-3419-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015177562
235 https://doi.org/10.1007/s10620-014-3419-5
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/ajg.2009.410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015352204
238 https://doi.org/10.1038/ajg.2009.410
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/s41575-020-00360-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1131495195
241 https://doi.org/10.1038/s41575-020-00360-x
242 rdf:type schema:CreativeWork
243 grid-institutes:grid.413618.9 schema:alternateName Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India
244 Department of Gastrointestinal Surgery, All India Institute of Medical Sciences, New Delhi, India
245 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
246 Department of Radio Diagnosis, All India Institute of Medical Sciences, New Delhi, India
247 schema:name Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, 3rd Floor, Teaching Block, 110029, New Delhi, Ansar Nagar, India
248 Department of Gastrointestinal Surgery, All India Institute of Medical Sciences, New Delhi, India
249 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India
250 Department of Radio Diagnosis, All India Institute of Medical Sciences, New Delhi, India
251 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...