Nomogram for predicting anastomotic leakage after low anterior resection for rectal cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-04

AUTHORS

Nobuaki Hoshino, Koya Hida, Yoshiharu Sakai, Shunichi Osada, Hitoshi Idani, Toshihiko Sato, Yasumasa Takii, Hiroyuki Bando, Akio Shiomi, Norio Saito

ABSTRACT

PURPOSE: Anastomotic leakage after low anterior resection for rectal cancer is a critical problem. Many risk factors have been suggested and surgical techniques have improved, but anastomotic leakage remains a major postoperative challenge. This study sought to create a nomogram for precise prediction of anastomotic leakage after low anterior resection for rectal cancer. METHODS: We used data of 936 patients that had been prospectively collected by the Japanese Society for Colon and Rectal Cancer between June 2010 and February 2013. Risk factors for anastomotic leakage were identified by multivariate logistic regression analysis and used to create a nomogram. The performance of the nomogram was evaluated by using a bootstrapped-concordance index and calibration plots. RESULTS: Sex, preoperative serum albumin, tumor location and diameter, and simultaneous resection of other organs were identified as significantly associated factors that could be combined for accurate prediction of anastomotic leakage. We created a nomogram for anastomotic leakage by using these risk factors. The area under the curve was 0.72 (95% confidence interval 0.67-0.76). The nomogram had a bootstrapped-concordance index of 0.72 and was well calibrated. CONCLUSIONS: Our nomogram was a useful tool for precise prediction of anastomotic leakage after low anterior resection for rectal cancer. More... »

PAGES

411-418

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00384-018-2970-5

DOI

http://dx.doi.org/10.1007/s00384-018-2970-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100859219

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29411120


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