Topic infliximab injection for refractory rectal stenosis in Crohn’s disease: long-term follow-up in two patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07-19

AUTHORS

Niels Teich, Ingo Wallstabe, Ingolf Schiefke

ABSTRACT

PurposeTNF blockers are approved for intravenous or subcutaneous systemic therapy of many chronic inflammatory diseases. As it is not possible to achieve a sufficient local clinical improvement through systemic therapy in every patient, diverse approaches of topical therapy using TNF blockers have been investigated in recent years.MethodsIn this paper, we report on long-term clinical results of originator infliximab (IFX) injections into symptomatic combined scarring and inflammatory stenoses of the rectum in two patients with Crohn’s disease. Aiming at high tissue IFX levels, 25 mg of IFX was injected into each quadrant of the stenosis after endoscopic balloon dilatation. This off-label treatment was repeated as necessary, depending on the clinical success.ResultsTopic IFX injection after balloon dilation reduced imperative stool pressure, isolated episodes of incontinence and incomplete emptying. Improvement lasted between 4 and 14 weeks in one patient and the treatment was repeated 13 times in the following 6.6 years. In the other patient, the technique was necessary only twice with no symptom recurrence in the subsequent 5.3 years.ConclusionOur experience suggests that topic application of a systemically approved anti-TNF substance may be a successful individualized therapy for refractory stenosis of the rectum in patients with Crohn’s disease. More... »

PAGES

1289-1294

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00384-017-2860-2

DOI

http://dx.doi.org/10.1007/s00384-017-2860-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090773366

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28725960


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