Layer-oriented total pelvic exenteration for locally advanced primary colorectal cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-01

AUTHORS

Keiji Koda, Kiyohiko Shuto, Kenichi Matsuo, Chihiro Kosugi, Mikito Mori, Atsushi Hirano, Yukihiko Hiroshima, Kuniya Tanaka

ABSTRACT

PURPOSE: The clinical outcomes of patients who have undergone total pelvic exenteration (TPE) for locally advanced primary colorectal cancer have not been satisfactory. For the last 13 years, we have performed layer-oriented, en bloc resection of tumor for which TPE is indicated, in the hope of improving postoperative outcomes. The clinical outcomes of these cases were retrospectively analyzed. METHODS: A total of 54 patients who underwent TPE from 1986 to 2013 were retrospectively analyzed. Since 2002, a layer-oriented removal for clinical T4 colorectal cancer, as in T3 or less invasive tumors removed by total mesorectal excision, was applied to 23 cases for which TPE was indicated. Postoperative mortality, morbidity, overall survival (OS), and disease-free survival (DFS) were evaluated. RESULTS: On univariate analysis, good postoperative OS and DFS were associated with the layer-oriented operative maneuver, blood loss less than 2000 mL, negative nodal metastasis, and no preoperative radiation therapy. Male sex was the marginal determinant correlated with good OS and DFS. Depth of invasion to T3 was the marginal determinant correlated with good DFS. On multivariate analysis using the 4 factors identified on univariate analyses, the layer-oriented operative procedure was a significant determinant for both good OS and DFS, together with negative nodal metastases. Postoperative mortality and morbidity in the layer-oriented excision were acceptable. CONCLUSION: For primary colorectal cancers for which TPE is indicated, layer-oriented excision was a safe and effective procedure, and it may be recommended as one of the standard surgical approaches in TPE. More... »

PAGES

59-66

References to SciGraph publications

  • 1993-01. Etiology and management of fecal incontinence in DISEASES OF THE COLON & RECTUM
  • 2003-04. Outcome of Total Pelvic Exenteration for Primary Rectal Cancer in DISEASES OF THE COLON & RECTUM
  • 2010-09. Pelvic Exenteration for Advanced and Recurrent Malignancy in WORLD JOURNAL OF SURGERY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00384-015-2353-0

    DOI

    http://dx.doi.org/10.1007/s00384-015-2353-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049475445

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/26255259


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Disease-Free Survival", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Hospital Mortality", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Intraoperative Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Multivariate Analysis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Recurrence, Local", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Staging", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pelvic Exenteration", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pelvis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Perioperative Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Teikyo University Chiba Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412406.5", 
              "name": [
                "Department of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 2990111, Ichihara City, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koda", 
            "givenName": "Keiji", 
            "id": "sg:person.0647155176.80", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647155176.80"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teikyo University Chiba Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412406.5", 
              "name": [
                "Department of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 2990111, Ichihara City, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shuto", 
            "givenName": "Kiyohiko", 
            "id": "sg:person.01361326355.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361326355.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teikyo University Chiba Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412406.5", 
              "name": [
                "Department of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 2990111, Ichihara City, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsuo", 
            "givenName": "Kenichi", 
            "id": "sg:person.011422271542.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011422271542.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teikyo University Chiba Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412406.5", 
              "name": [
                "Department of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 2990111, Ichihara City, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kosugi", 
            "givenName": "Chihiro", 
            "id": "sg:person.01213167443.37", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213167443.37"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teikyo University Chiba Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412406.5", 
              "name": [
                "Department of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 2990111, Ichihara City, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mori", 
            "givenName": "Mikito", 
            "id": "sg:person.01133656514.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133656514.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teikyo University Chiba Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412406.5", 
              "name": [
                "Department of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 2990111, Ichihara City, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hirano", 
            "givenName": "Atsushi", 
            "id": "sg:person.01257014672.12", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257014672.12"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teikyo University Chiba Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412406.5", 
              "name": [
                "Department of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 2990111, Ichihara City, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hiroshima", 
            "givenName": "Yukihiko", 
            "id": "sg:person.0667317630.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667317630.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Teikyo University Chiba Medical Center", 
              "id": "https://www.grid.ac/institutes/grid.412406.5", 
              "name": [
                "Department of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 2990111, Ichihara City, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Kuniya", 
            "id": "sg:person.010326230774.92", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010326230774.92"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/bf02050307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001377909", 
              "https://doi.org/10.1007/bf02050307"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/bf02050307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001377909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/bf02050307", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001377909"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0960-7404(10)80041-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002579258"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10350-004-6585-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004877134", 
              "https://doi.org/10.1007/s10350-004-6585-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/s10350-004-6585-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004877134"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2168.2002.02212.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019640668"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-010-0637-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021033120", 
              "https://doi.org/10.1007/s00268-010-0637-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-010-0637-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021033120", 
              "https://doi.org/10.1007/s00268-010-0637-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/dcr.0b013e3181e74525", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026182510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1007/dcr.0b013e3181e74525", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026182510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/dcr.0b013e31827a7868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028303219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/dcr.0b013e31827a7868", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028303219"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-198806000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038338926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-198806000-00005", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038338926"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000099169", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041639581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa032709", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042555196"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-198204000-00022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043938700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000658-198204000-00022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043938700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0140-6736(93)90207-w", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049775581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ejso.2006.09.021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052398996"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1463-1318.2011.02893.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053648252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1503/cjs.014010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067426187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1503/cjs.014010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1067426187"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2016-01", 
        "datePublishedReg": "2016-01-01", 
        "description": "PURPOSE: The clinical outcomes of patients who have undergone total pelvic exenteration (TPE) for locally advanced primary colorectal cancer have not been satisfactory. For the last 13 years, we have performed layer-oriented, en bloc resection of tumor for which TPE is indicated, in the hope of improving postoperative outcomes. The clinical outcomes of these cases were retrospectively analyzed.\nMETHODS: A total of 54 patients who underwent TPE from 1986 to 2013 were retrospectively analyzed. Since 2002, a layer-oriented removal for clinical T4 colorectal cancer, as in T3 or less invasive tumors removed by total mesorectal excision, was applied to 23 cases for which TPE was indicated. Postoperative mortality, morbidity, overall survival (OS), and disease-free survival (DFS) were evaluated.\nRESULTS: On univariate analysis, good postoperative OS and DFS were associated with the layer-oriented operative maneuver, blood loss less than 2000 mL, negative nodal metastasis, and no preoperative radiation therapy. Male sex was the marginal determinant correlated with good OS and DFS. Depth of invasion to T3 was the marginal determinant correlated with good DFS. On multivariate analysis using the 4 factors identified on univariate analyses, the layer-oriented operative procedure was a significant determinant for both good OS and DFS, together with negative nodal metastases. Postoperative mortality and morbidity in the layer-oriented excision were acceptable.\nCONCLUSION: For primary colorectal cancers for which TPE is indicated, layer-oriented excision was a safe and effective procedure, and it may be recommended as one of the standard surgical approaches in TPE.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00384-015-2353-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1096381", 
            "issn": [
              "0179-1958", 
              "1432-1262"
            ], 
            "name": "International Journal of Colorectal Disease", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "31"
          }
        ], 
        "name": "Layer-oriented total pelvic exenteration for locally advanced primary colorectal cancer", 
        "pagination": "59-66", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "ebb097b6a8ec585329bd0bffb18507645c401886e5d83d4f38bbc2ca2eaad3af"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "26255259"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8607899"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00384-015-2353-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1049475445"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00384-015-2353-0", 
          "https://app.dimensions.ai/details/publication/pub.1049475445"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T22:33", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000516.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs00384-015-2353-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00384-015-2353-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00384-015-2353-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00384-015-2353-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00384-015-2353-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    248 TRIPLES      21 PREDICATES      65 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00384-015-2353-0 schema:about N07c117f1ba5b4550a13da7c6696b5a8b
    2 N0b6427a4ce644b08865f647530b71489
    3 N1e3cf71a1ab64c4c84593212738737a7
    4 N26cc6251add2419dabad23c8e4ca9b51
    5 N41662a19b5fd41139df725fc4f59f8d0
    6 N4f099443bc8d4c328759d928356edf71
    7 N6f0c67ef28a44c1ba77970ef10d4f87e
    8 N774d7d542ace42029a9a575c88f472de
    9 N79d6d4769f2f452c94ef92c20d440d6e
    10 N96a6a9dce70a4c31b4c7f55e1115a3ec
    11 N998154cb0293422887cfb6feb076cce5
    12 Nb04b5242f10e4a34a8435f30b9c4f0c1
    13 Nb8e9fe0a088948b5a5fd0d5944c8f83a
    14 Nbce94b80f4174609967815cbcda559e9
    15 Nd02372d92d464670a060e083f96a2a23
    16 Ne683091094014cdb9f2249348e903603
    17 Neb6a699472184cb89ab41f1edb3d16ed
    18 Nf1d36b02148c426587f1722f234be6ad
    19 Nfaf9ed9eb3ef4187be05ac5dc899d488
    20 anzsrc-for:11
    21 anzsrc-for:1112
    22 schema:author N9c312748b3a8415c85a23defeb99eb35
    23 schema:citation sg:pub.10.1007/bf02050307
    24 sg:pub.10.1007/s00268-010-0637-7
    25 sg:pub.10.1007/s10350-004-6585-2
    26 https://doi.org/10.1007/bf02050307
    27 https://doi.org/10.1007/dcr.0b013e3181e74525
    28 https://doi.org/10.1007/s10350-004-6585-2
    29 https://doi.org/10.1016/0140-6736(93)90207-w
    30 https://doi.org/10.1016/j.ejso.2006.09.021
    31 https://doi.org/10.1016/s0960-7404(10)80041-6
    32 https://doi.org/10.1046/j.1365-2168.2002.02212.x
    33 https://doi.org/10.1056/nejmoa032709
    34 https://doi.org/10.1097/00000658-198204000-00022
    35 https://doi.org/10.1097/00000658-198806000-00005
    36 https://doi.org/10.1097/dcr.0b013e31827a7868
    37 https://doi.org/10.1111/j.1463-1318.2011.02893.x
    38 https://doi.org/10.1159/000099169
    39 https://doi.org/10.1503/cjs.014010
    40 schema:datePublished 2016-01
    41 schema:datePublishedReg 2016-01-01
    42 schema:description PURPOSE: The clinical outcomes of patients who have undergone total pelvic exenteration (TPE) for locally advanced primary colorectal cancer have not been satisfactory. For the last 13 years, we have performed layer-oriented, en bloc resection of tumor for which TPE is indicated, in the hope of improving postoperative outcomes. The clinical outcomes of these cases were retrospectively analyzed. METHODS: A total of 54 patients who underwent TPE from 1986 to 2013 were retrospectively analyzed. Since 2002, a layer-oriented removal for clinical T4 colorectal cancer, as in T3 or less invasive tumors removed by total mesorectal excision, was applied to 23 cases for which TPE was indicated. Postoperative mortality, morbidity, overall survival (OS), and disease-free survival (DFS) were evaluated. RESULTS: On univariate analysis, good postoperative OS and DFS were associated with the layer-oriented operative maneuver, blood loss less than 2000 mL, negative nodal metastasis, and no preoperative radiation therapy. Male sex was the marginal determinant correlated with good OS and DFS. Depth of invasion to T3 was the marginal determinant correlated with good DFS. On multivariate analysis using the 4 factors identified on univariate analyses, the layer-oriented operative procedure was a significant determinant for both good OS and DFS, together with negative nodal metastases. Postoperative mortality and morbidity in the layer-oriented excision were acceptable. CONCLUSION: For primary colorectal cancers for which TPE is indicated, layer-oriented excision was a safe and effective procedure, and it may be recommended as one of the standard surgical approaches in TPE.
    43 schema:genre research_article
    44 schema:inLanguage en
    45 schema:isAccessibleForFree false
    46 schema:isPartOf N68bcbac38a39400cae506b508d2d0f8c
    47 N7fa75478cb2a41608495bdde03d741eb
    48 sg:journal.1096381
    49 schema:name Layer-oriented total pelvic exenteration for locally advanced primary colorectal cancer
    50 schema:pagination 59-66
    51 schema:productId N009521edb1d84a63a70b22fadf524637
    52 N160d1e089b5843afbe163719ba42ea5a
    53 N654c927ef8ed4b9c956675c0f9230ca8
    54 N795a555837394c2eb854c295b4e699c7
    55 N84310798dd30467ea2db63248552801a
    56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049475445
    57 https://doi.org/10.1007/s00384-015-2353-0
    58 schema:sdDatePublished 2019-04-10T22:33
    59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    60 schema:sdPublisher Nfc455b887fc349ce9ba6d656f81ba881
    61 schema:url http://link.springer.com/10.1007%2Fs00384-015-2353-0
    62 sgo:license sg:explorer/license/
    63 sgo:sdDataset articles
    64 rdf:type schema:ScholarlyArticle
    65 N009521edb1d84a63a70b22fadf524637 schema:name nlm_unique_id
    66 schema:value 8607899
    67 rdf:type schema:PropertyValue
    68 N07c117f1ba5b4550a13da7c6696b5a8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    69 schema:name Hospital Mortality
    70 rdf:type schema:DefinedTerm
    71 N0b6427a4ce644b08865f647530b71489 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    72 schema:name Adult
    73 rdf:type schema:DefinedTerm
    74 N159fbb1278924393abc5034a3d49af24 rdf:first sg:person.010326230774.92
    75 rdf:rest rdf:nil
    76 N160d1e089b5843afbe163719ba42ea5a schema:name doi
    77 schema:value 10.1007/s00384-015-2353-0
    78 rdf:type schema:PropertyValue
    79 N1e3cf71a1ab64c4c84593212738737a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Neoplasm Recurrence, Local
    81 rdf:type schema:DefinedTerm
    82 N26cc6251add2419dabad23c8e4ca9b51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    83 schema:name Middle Aged
    84 rdf:type schema:DefinedTerm
    85 N41662a19b5fd41139df725fc4f59f8d0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    86 schema:name Multivariate Analysis
    87 rdf:type schema:DefinedTerm
    88 N4f099443bc8d4c328759d928356edf71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    89 schema:name Aged, 80 and over
    90 rdf:type schema:DefinedTerm
    91 N5911411f34dd4b9fb9f43bee3e5efb93 rdf:first sg:person.0667317630.14
    92 rdf:rest N159fbb1278924393abc5034a3d49af24
    93 N654c927ef8ed4b9c956675c0f9230ca8 schema:name dimensions_id
    94 schema:value pub.1049475445
    95 rdf:type schema:PropertyValue
    96 N68bcbac38a39400cae506b508d2d0f8c schema:volumeNumber 31
    97 rdf:type schema:PublicationVolume
    98 N6f0c67ef28a44c1ba77970ef10d4f87e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Aged
    100 rdf:type schema:DefinedTerm
    101 N774d7d542ace42029a9a575c88f472de schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    102 schema:name Prognosis
    103 rdf:type schema:DefinedTerm
    104 N795a555837394c2eb854c295b4e699c7 schema:name readcube_id
    105 schema:value ebb097b6a8ec585329bd0bffb18507645c401886e5d83d4f38bbc2ca2eaad3af
    106 rdf:type schema:PropertyValue
    107 N79d6d4769f2f452c94ef92c20d440d6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Neoplasm Staging
    109 rdf:type schema:DefinedTerm
    110 N7fa75478cb2a41608495bdde03d741eb schema:issueNumber 1
    111 rdf:type schema:PublicationIssue
    112 N84310798dd30467ea2db63248552801a schema:name pubmed_id
    113 schema:value 26255259
    114 rdf:type schema:PropertyValue
    115 N954965625c5b4aef9b6fb4e842e693ef rdf:first sg:person.011422271542.21
    116 rdf:rest Ne64a9456ff35456fbdf9a24a90a3e7ca
    117 N96a6a9dce70a4c31b4c7f55e1115a3ec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Colorectal Neoplasms
    119 rdf:type schema:DefinedTerm
    120 N998154cb0293422887cfb6feb076cce5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Disease-Free Survival
    122 rdf:type schema:DefinedTerm
    123 N9c312748b3a8415c85a23defeb99eb35 rdf:first sg:person.0647155176.80
    124 rdf:rest Nce7ef7c7b0a145ab9e6b73b09ef17887
    125 Na4ee647fcc054a4998f70f6ff64c9d0e rdf:first sg:person.01257014672.12
    126 rdf:rest N5911411f34dd4b9fb9f43bee3e5efb93
    127 Nb04b5242f10e4a34a8435f30b9c4f0c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Female
    129 rdf:type schema:DefinedTerm
    130 Nb8e9fe0a088948b5a5fd0d5944c8f83a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Humans
    132 rdf:type schema:DefinedTerm
    133 Nbce94b80f4174609967815cbcda559e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Intraoperative Care
    135 rdf:type schema:DefinedTerm
    136 Nce7ef7c7b0a145ab9e6b73b09ef17887 rdf:first sg:person.01361326355.05
    137 rdf:rest N954965625c5b4aef9b6fb4e842e693ef
    138 Nd02372d92d464670a060e083f96a2a23 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Pelvic Exenteration
    140 rdf:type schema:DefinedTerm
    141 Ne64a9456ff35456fbdf9a24a90a3e7ca rdf:first sg:person.01213167443.37
    142 rdf:rest Neb1ea0bb9dd740498f96669cf9a0304b
    143 Ne683091094014cdb9f2249348e903603 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Male
    145 rdf:type schema:DefinedTerm
    146 Neb1ea0bb9dd740498f96669cf9a0304b rdf:first sg:person.01133656514.23
    147 rdf:rest Na4ee647fcc054a4998f70f6ff64c9d0e
    148 Neb6a699472184cb89ab41f1edb3d16ed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Pelvis
    150 rdf:type schema:DefinedTerm
    151 Nf1d36b02148c426587f1722f234be6ad schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Perioperative Care
    153 rdf:type schema:DefinedTerm
    154 Nfaf9ed9eb3ef4187be05ac5dc899d488 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Treatment Outcome
    156 rdf:type schema:DefinedTerm
    157 Nfc455b887fc349ce9ba6d656f81ba881 schema:name Springer Nature - SN SciGraph project
    158 rdf:type schema:Organization
    159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Medical and Health Sciences
    161 rdf:type schema:DefinedTerm
    162 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    163 schema:name Oncology and Carcinogenesis
    164 rdf:type schema:DefinedTerm
    165 sg:journal.1096381 schema:issn 0179-1958
    166 1432-1262
    167 schema:name International Journal of Colorectal Disease
    168 rdf:type schema:Periodical
    169 sg:person.010326230774.92 schema:affiliation https://www.grid.ac/institutes/grid.412406.5
    170 schema:familyName Tanaka
    171 schema:givenName Kuniya
    172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010326230774.92
    173 rdf:type schema:Person
    174 sg:person.01133656514.23 schema:affiliation https://www.grid.ac/institutes/grid.412406.5
    175 schema:familyName Mori
    176 schema:givenName Mikito
    177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133656514.23
    178 rdf:type schema:Person
    179 sg:person.011422271542.21 schema:affiliation https://www.grid.ac/institutes/grid.412406.5
    180 schema:familyName Matsuo
    181 schema:givenName Kenichi
    182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011422271542.21
    183 rdf:type schema:Person
    184 sg:person.01213167443.37 schema:affiliation https://www.grid.ac/institutes/grid.412406.5
    185 schema:familyName Kosugi
    186 schema:givenName Chihiro
    187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213167443.37
    188 rdf:type schema:Person
    189 sg:person.01257014672.12 schema:affiliation https://www.grid.ac/institutes/grid.412406.5
    190 schema:familyName Hirano
    191 schema:givenName Atsushi
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01257014672.12
    193 rdf:type schema:Person
    194 sg:person.01361326355.05 schema:affiliation https://www.grid.ac/institutes/grid.412406.5
    195 schema:familyName Shuto
    196 schema:givenName Kiyohiko
    197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361326355.05
    198 rdf:type schema:Person
    199 sg:person.0647155176.80 schema:affiliation https://www.grid.ac/institutes/grid.412406.5
    200 schema:familyName Koda
    201 schema:givenName Keiji
    202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647155176.80
    203 rdf:type schema:Person
    204 sg:person.0667317630.14 schema:affiliation https://www.grid.ac/institutes/grid.412406.5
    205 schema:familyName Hiroshima
    206 schema:givenName Yukihiko
    207 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667317630.14
    208 rdf:type schema:Person
    209 sg:pub.10.1007/bf02050307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001377909
    210 https://doi.org/10.1007/bf02050307
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1007/s00268-010-0637-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021033120
    213 https://doi.org/10.1007/s00268-010-0637-7
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1007/s10350-004-6585-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004877134
    216 https://doi.org/10.1007/s10350-004-6585-2
    217 rdf:type schema:CreativeWork
    218 https://doi.org/10.1007/bf02050307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001377909
    219 rdf:type schema:CreativeWork
    220 https://doi.org/10.1007/dcr.0b013e3181e74525 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026182510
    221 rdf:type schema:CreativeWork
    222 https://doi.org/10.1007/s10350-004-6585-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004877134
    223 rdf:type schema:CreativeWork
    224 https://doi.org/10.1016/0140-6736(93)90207-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1049775581
    225 rdf:type schema:CreativeWork
    226 https://doi.org/10.1016/j.ejso.2006.09.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052398996
    227 rdf:type schema:CreativeWork
    228 https://doi.org/10.1016/s0960-7404(10)80041-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002579258
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1046/j.1365-2168.2002.02212.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019640668
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1056/nejmoa032709 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042555196
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1097/00000658-198204000-00022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043938700
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1097/00000658-198806000-00005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038338926
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1097/dcr.0b013e31827a7868 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028303219
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1111/j.1463-1318.2011.02893.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053648252
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1159/000099169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041639581
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1503/cjs.014010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067426187
    245 rdf:type schema:CreativeWork
    246 https://www.grid.ac/institutes/grid.412406.5 schema:alternateName Teikyo University Chiba Medical Center
    247 schema:name Department of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, 2990111, Ichihara City, Chiba, Japan
    248 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...