Endoscopic finding of spontaneous hemorrhage correlates with tumor necrosis factor alpha expression in colonic mucosa of patients with ulcerative colitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-02-03

AUTHORS

Hideaki Hozumi, Ryota Hokari, Chie Kurihara, Kazuyuki Narimatsu, Hirokazu Sato, Shingo Sato, Toshihide Ueda, Masaaki Higashiyama, Yoshikiyo Okada, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Atsushi Kawaguchi, Shigeaki Nagao, Soichiro Miura

ABSTRACT

BackgroundUlcerative colitis (UC) is an intractable colonic disease, and it shows several endoscopic findings. Recently, it was reported that the expression level of mucosal tumor necrosis factor alpha (TNF-α) was useful for predicting patient response to infliximab. However, no data regarding the value of endoscopic findings to predict treatment efficacy or cytokine expression level exist.ObjectiveWe investigated the expression of leukocyte adhesion-related molecules and cytokines in colonic mucosa and compared it to endoscopic findings.MethodsOne hundred and fifty-nine patients were enrolled. Tissue samples were obtained by colonic biopsy from patients with UC. Colitis activity was determined by Matts’ criteria. The degree of mRNA expression of TNF-α, interferon gamma (IFN-γ), interleukin (IL)-8, IL-17A, and mucosal vascular addressin adhesion molecule-1 (MAdCAM-1) in mucosal samples was determined by real-time quantitative polymerase chain reaction. These expression levels were compared with the degree of Matts’ grade and individual endoscopic findings.ResultsThe expression of TNF-α, IFN-γ, IL-8, IL-17A, and MAdCAM-1 mRNA significantly increased as Matts’ endoscopic grade elevated. Actively inflamed mucosa with spontaneous hemorrhage revealed a significantly increased expression level of TNF-α mRNA than that without spontaneous hemorrhage. No other individual endoscopic parameter was significantly correlated with the expression level of TNF-α mRNA.ConclusionsInflamed mucosa with spontaneous hemorrhage may suggest increased expression of TNF-α mRNA levels in colonic mucosa of UC patients, which could predict a lower response to infliximab treatment and more aggressive induction regime or change to other therapy should be taken into account. More... »

PAGES

1049-1055

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00384-013-1654-4

DOI

http://dx.doi.org/10.1007/s00384-013-1654-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046467048

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23377880


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26 schema:description BackgroundUlcerative colitis (UC) is an intractable colonic disease, and it shows several endoscopic findings. Recently, it was reported that the expression level of mucosal tumor necrosis factor alpha (TNF-α) was useful for predicting patient response to infliximab. However, no data regarding the value of endoscopic findings to predict treatment efficacy or cytokine expression level exist.ObjectiveWe investigated the expression of leukocyte adhesion-related molecules and cytokines in colonic mucosa and compared it to endoscopic findings.MethodsOne hundred and fifty-nine patients were enrolled. Tissue samples were obtained by colonic biopsy from patients with UC. Colitis activity was determined by Matts’ criteria. The degree of mRNA expression of TNF-α, interferon gamma (IFN-γ), interleukin (IL)-8, IL-17A, and mucosal vascular addressin adhesion molecule-1 (MAdCAM-1) in mucosal samples was determined by real-time quantitative polymerase chain reaction. These expression levels were compared with the degree of Matts’ grade and individual endoscopic findings.ResultsThe expression of TNF-α, IFN-γ, IL-8, IL-17A, and MAdCAM-1 mRNA significantly increased as Matts’ endoscopic grade elevated. Actively inflamed mucosa with spontaneous hemorrhage revealed a significantly increased expression level of TNF-α mRNA than that without spontaneous hemorrhage. No other individual endoscopic parameter was significantly correlated with the expression level of TNF-α mRNA.ConclusionsInflamed mucosa with spontaneous hemorrhage may suggest increased expression of TNF-α mRNA levels in colonic mucosa of UC patients, which could predict a lower response to infliximab treatment and more aggressive induction regime or change to other therapy should be taken into account.
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33 schema:keywords BackgroundUlcerative colitis
34 ConclusionsInflamed mucosa
35 IFN
36 IL-17A
37 IL-8
38 MAdCAM-1 mRNA
39 Matt
40 Matts grade
41 Matts’ endoscopic grade
42 MethodsOne hundred
43 ObjectiveWe
44 TNF
45 UC
46 UC patients
47 account
48 activity
49 addressin adhesion molecule-1
50 adhesion molecule-1
51 adhesion-related molecules
52 aggressive induction regime
53 alpha
54 alpha expression
55 biopsy
56 chain reaction
57 changes
58 colitis
59 colitis activity
60 colonic biopsies
61 colonic disease
62 colonic mucosa
63 correlates
64 criteria
65 cytokine expression level exist
66 cytokines
67 data
68 degree
69 disease
70 efficacy
71 endoscopic findings
72 endoscopic grade
73 endoscopic parameters
74 exists
75 expression
76 expression level exist
77 expression levels
78 expression of TNF
79 factor alpha
80 factor alpha expression
81 findings
82 gamma
83 grade
84 hemorrhage
85 hemorrhage correlates
86 hundreds
87 individual endoscopic findings
88 individual endoscopic parameter
89 induction regime
90 infliximab
91 interferon gamma
92 interleukin
93 intractable colonic disease
94 leukocyte adhesion-related molecules
95 level exists
96 levels
97 low response
98 mRNA
99 mRNA expression
100 mRNA levels
101 molecule-1
102 molecules
103 mucosa
104 mucosal samples
105 mucosal tumor necrosis factor alpha
106 mucosal vascular addressin adhesion molecule-1
107 necrosis factor alpha
108 necrosis factor-alpha expression
109 parameters
110 patient response
111 patients
112 polymerase chain reaction
113 quantitative polymerase chain reaction
114 reaction
115 real-time quantitative polymerase chain reaction
116 regime
117 response
118 samples
119 spontaneous hemorrhage
120 spontaneous hemorrhage correlates
121 therapy
122 tissue samples
123 treatment
124 treatment efficacy
125 tumor necrosis factor alpha
126 tumor necrosis factor-alpha expression
127 ulcerative colitis
128 values
129 vascular addressin adhesion molecule-1
130 schema:name Endoscopic finding of spontaneous hemorrhage correlates with tumor necrosis factor alpha expression in colonic mucosa of patients with ulcerative colitis
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