Endoscopic finding of spontaneous hemorrhage correlates with tumor necrosis factor alpha expression in colonic mucosa of patients with ulcerative colitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08

AUTHORS

Hideaki Hozumi, Ryota Hokari, Chie Kurihara, Kazuyuki Narimatsu, Hirokazu Sato, Shingo Sato, Toshihide Ueda, Masaaki Higashiyama, Yoshikiyo Okada, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Atsushi Kawaguchi, Shigeaki Nagao, Soichiro Miura

ABSTRACT

BACKGROUND: Ulcerative colitis (UC) is an intractable colonic disease, and it shows several endoscopic findings. Recently, it was reported that the expression level of mucosal tumor necrosis factor alpha (TNF-α) was useful for predicting patient response to infliximab. However, no data regarding the value of endoscopic findings to predict treatment efficacy or cytokine expression level exist. OBJECTIVE: We investigated the expression of leukocyte adhesion-related molecules and cytokines in colonic mucosa and compared it to endoscopic findings. METHODS: One hundred and fifty-nine patients were enrolled. Tissue samples were obtained by colonic biopsy from patients with UC. Colitis activity was determined by Matts' criteria. The degree of mRNA expression of TNF-α, interferon gamma (IFN-γ), interleukin (IL)-8, IL-17A, and mucosal vascular addressin adhesion molecule-1 (MAdCAM-1) in mucosal samples was determined by real-time quantitative polymerase chain reaction. These expression levels were compared with the degree of Matts' grade and individual endoscopic findings. RESULTS: The expression of TNF-α, IFN-γ, IL-8, IL-17A, and MAdCAM-1 mRNA significantly increased as Matts' endoscopic grade elevated. Actively inflamed mucosa with spontaneous hemorrhage revealed a significantly increased expression level of TNF-α mRNA than that without spontaneous hemorrhage. No other individual endoscopic parameter was significantly correlated with the expression level of TNF-α mRNA. CONCLUSIONS: Inflamed mucosa with spontaneous hemorrhage may suggest increased expression of TNF-α mRNA levels in colonic mucosa of UC patients, which could predict a lower response to infliximab treatment and more aggressive induction regime or change to other therapy should be taken into account. More... »

PAGES

1049-1055

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00384-013-1654-4

DOI

http://dx.doi.org/10.1007/s00384-013-1654-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046467048

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23377880


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colitis, Ulcerative", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colonoscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Hemorrhage", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Logistic Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Odds Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hozumi", 
        "givenName": "Hideaki", 
        "id": "sg:person.01035330071.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035330071.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hokari", 
        "givenName": "Ryota", 
        "id": "sg:person.01216365616.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216365616.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kurihara", 
        "givenName": "Chie", 
        "id": "sg:person.01332614216.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332614216.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Narimatsu", 
        "givenName": "Kazuyuki", 
        "id": "sg:person.01365030634.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365030634.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Hirokazu", 
        "id": "sg:person.01300535632.67", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300535632.67"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sato", 
        "givenName": "Shingo", 
        "id": "sg:person.01346651032.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346651032.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueda", 
        "givenName": "Toshihide", 
        "id": "sg:person.01231671347.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231671347.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Higashiyama", 
        "givenName": "Masaaki", 
        "id": "sg:person.0734300745.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734300745.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Okada", 
        "givenName": "Yoshikiyo", 
        "id": "sg:person.0670627047.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670627047.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Watanabe", 
        "givenName": "Chikako", 
        "id": "sg:person.01300004547.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300004547.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Komoto", 
        "givenName": "Shunsuke", 
        "id": "sg:person.01012710761.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012710761.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tomita", 
        "givenName": "Kengo", 
        "id": "sg:person.01353336467.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353336467.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawaguchi", 
        "givenName": "Atsushi", 
        "id": "sg:person.01041700765.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041700765.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagao", 
        "givenName": "Shigeaki", 
        "id": "sg:person.01110014165.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110014165.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Defense Medical College", 
          "id": "https://www.grid.ac/institutes/grid.416614.0", 
          "name": [
            "Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Miura", 
        "givenName": "Soichiro", 
        "id": "sg:person.01053170647.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053170647.97"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70381-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000627345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70381-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000627345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra020831", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004344000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011250403", 
          "https://doi.org/10.1038/nature10209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2010.224154", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013261660"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2009.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014304165"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.45.6.856", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015066898"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(94)90614-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018221919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2002.31899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021117209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1102942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026919634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/gut.2006.115980", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031837511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000195133.98378.4b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040027274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.str.0000195133.98378.4b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040027274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(95)90599-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044650773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2006.03.054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044930424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/1043-4666(90)90012-i", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047599043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1227/01.neu.0000170439.89041.d6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049608614"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200008000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051679917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000478-200008000-00009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051679917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2009.02.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052517958"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1549-8719.2001.tb00177.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053217658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1549-8719.2001.tb00177.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053217658"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02934086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053459106", 
          "https://doi.org/10.1007/bf02934086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02934086", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053459106", 
          "https://doi.org/10.1007/bf02934086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/vhrm.s2700", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069103005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075051693", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076546633", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082991571", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083113462", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1998.275.1.e27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083300047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpendo.1998.275.1.e27", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083300047"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-08", 
    "datePublishedReg": "2013-08-01", 
    "description": "BACKGROUND: Ulcerative colitis (UC) is an intractable colonic disease, and it shows several endoscopic findings. Recently, it was reported that the expression level of mucosal tumor necrosis factor alpha (TNF-\u03b1) was useful for predicting patient response to infliximab. However, no data regarding the value of endoscopic findings to predict treatment efficacy or cytokine expression level exist.\nOBJECTIVE: We investigated the expression of leukocyte adhesion-related molecules and cytokines in colonic mucosa and compared it to endoscopic findings.\nMETHODS: One hundred and fifty-nine patients were enrolled. Tissue samples were obtained by colonic biopsy from patients with UC. Colitis activity was determined by Matts' criteria. The degree of mRNA expression of TNF-\u03b1, interferon gamma (IFN-\u03b3), interleukin (IL)-8, IL-17A, and mucosal vascular addressin adhesion molecule-1 (MAdCAM-1) in mucosal samples was determined by real-time quantitative polymerase chain reaction. These expression levels were compared with the degree of Matts' grade and individual endoscopic findings.\nRESULTS: The expression of TNF-\u03b1, IFN-\u03b3, IL-8, IL-17A, and MAdCAM-1 mRNA significantly increased as Matts' endoscopic grade elevated. Actively inflamed mucosa with spontaneous hemorrhage revealed a significantly increased expression level of TNF-\u03b1 mRNA than that without spontaneous hemorrhage. No other individual endoscopic parameter was significantly correlated with the expression level of TNF-\u03b1 mRNA.\nCONCLUSIONS: Inflamed mucosa with spontaneous hemorrhage may suggest increased expression of TNF-\u03b1 mRNA levels in colonic mucosa of UC patients, which could predict a lower response to infliximab treatment and more aggressive induction regime or change to other therapy should be taken into account.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00384-013-1654-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096381", 
        "issn": [
          "0179-1958", 
          "1432-1262"
        ], 
        "name": "International Journal of Colorectal Disease", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "name": "Endoscopic finding of spontaneous hemorrhage correlates with tumor necrosis factor alpha expression in colonic mucosa of patients with ulcerative colitis", 
    "pagination": "1049-1055", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "dd59cebdf1a2a2da07fefd09bcf4f6d3052a13f9a6f9375b840ca2bdab0f1a7b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23377880"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8607899"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00384-013-1654-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046467048"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00384-013-1654-4", 
      "https://app.dimensions.ai/details/publication/pub.1046467048"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:09", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8678_00000515.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00384-013-1654-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00384-013-1654-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00384-013-1654-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00384-013-1654-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00384-013-1654-4'


 

This table displays all metadata directly associated to this object as RDF triples.

312 TRIPLES      21 PREDICATES      72 URIs      39 LITERALS      27 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00384-013-1654-4 schema:about N03d294db90b845b1a809ab69d2bb3426
2 N0821bbfc430b4e60af0c98290a646006
3 N0eae4fdf5a5e44569513c4ae5a549f35
4 N12d271af83be495bb31150b36a3e1ecb
5 N44b738e0d5b1463081737b0433bce41d
6 N469b04e97ce542128d7f090c860ed819
7 N4bde1b432ede45e5924163505b2a3f8d
8 N59cb5bdc94b54cd5900b5aaacb7a41a2
9 N6bc53956dc234dc6b58706862902307e
10 N731f79c7e0b94c6d8ccc990a8a344207
11 N90f2cd5f37e2499a997faab69059fd38
12 Na168e35e203e4e99bd03c474dfa0570c
13 Nac45dfa223ac4a0dad0f0e09232bf7fb
14 Nb3e1ba2a7e924a838da75f7361ac2943
15 Nc414913b31f64d949fa7461d5d24f819
16 Nd4bf6f47da0b43d2b0809210d11edc84
17 Ne4318230e6524d62b242249c5329642d
18 Nfc869cf49d1a41088e7d5b322db23812
19 anzsrc-for:11
20 anzsrc-for:1103
21 schema:author N17b6e2c594464b28b0abcf5cf926519d
22 schema:citation sg:pub.10.1007/bf02934086
23 sg:pub.10.1038/nature10209
24 https://app.dimensions.ai/details/publication/pub.1075051693
25 https://app.dimensions.ai/details/publication/pub.1076546633
26 https://app.dimensions.ai/details/publication/pub.1082991571
27 https://app.dimensions.ai/details/publication/pub.1083113462
28 https://doi.org/10.1016/0016-5085(94)90614-9
29 https://doi.org/10.1016/0016-5085(95)90599-5
30 https://doi.org/10.1016/1043-4666(90)90012-i
31 https://doi.org/10.1016/j.cyto.2009.02.001
32 https://doi.org/10.1016/s0016-5085(98)70381-6
33 https://doi.org/10.1053/gast.2002.31899
34 https://doi.org/10.1053/j.gastro.2006.03.054
35 https://doi.org/10.1053/j.gastro.2009.02.001
36 https://doi.org/10.1056/nejmra020831
37 https://doi.org/10.1056/nejmra1102942
38 https://doi.org/10.1097/00000478-200008000-00009
39 https://doi.org/10.1111/j.1549-8719.2001.tb00177.x
40 https://doi.org/10.1136/gut.2006.115980
41 https://doi.org/10.1136/gut.2010.224154
42 https://doi.org/10.1136/gut.45.6.856
43 https://doi.org/10.1152/ajpendo.1998.275.1.e27
44 https://doi.org/10.1161/01.str.0000195133.98378.4b
45 https://doi.org/10.1227/01.neu.0000170439.89041.d6
46 https://doi.org/10.2147/vhrm.s2700
47 schema:datePublished 2013-08
48 schema:datePublishedReg 2013-08-01
49 schema:description BACKGROUND: Ulcerative colitis (UC) is an intractable colonic disease, and it shows several endoscopic findings. Recently, it was reported that the expression level of mucosal tumor necrosis factor alpha (TNF-α) was useful for predicting patient response to infliximab. However, no data regarding the value of endoscopic findings to predict treatment efficacy or cytokine expression level exist. OBJECTIVE: We investigated the expression of leukocyte adhesion-related molecules and cytokines in colonic mucosa and compared it to endoscopic findings. METHODS: One hundred and fifty-nine patients were enrolled. Tissue samples were obtained by colonic biopsy from patients with UC. Colitis activity was determined by Matts' criteria. The degree of mRNA expression of TNF-α, interferon gamma (IFN-γ), interleukin (IL)-8, IL-17A, and mucosal vascular addressin adhesion molecule-1 (MAdCAM-1) in mucosal samples was determined by real-time quantitative polymerase chain reaction. These expression levels were compared with the degree of Matts' grade and individual endoscopic findings. RESULTS: The expression of TNF-α, IFN-γ, IL-8, IL-17A, and MAdCAM-1 mRNA significantly increased as Matts' endoscopic grade elevated. Actively inflamed mucosa with spontaneous hemorrhage revealed a significantly increased expression level of TNF-α mRNA than that without spontaneous hemorrhage. No other individual endoscopic parameter was significantly correlated with the expression level of TNF-α mRNA. CONCLUSIONS: Inflamed mucosa with spontaneous hemorrhage may suggest increased expression of TNF-α mRNA levels in colonic mucosa of UC patients, which could predict a lower response to infliximab treatment and more aggressive induction regime or change to other therapy should be taken into account.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree false
53 schema:isPartOf N48093f9a741245aa919e38251d88c778
54 N98b165319ae64e96b89a3e532047b2a0
55 sg:journal.1096381
56 schema:name Endoscopic finding of spontaneous hemorrhage correlates with tumor necrosis factor alpha expression in colonic mucosa of patients with ulcerative colitis
57 schema:pagination 1049-1055
58 schema:productId N266ee84a264d4691869415b2cfe64f9d
59 N2eccc63a12344cb38b1af5dbd0177368
60 N37b3d067ac7f4fed8a707130d6242e7a
61 N46d68665fb1b43db8d9954d9171ad7c1
62 Ndb637c99c0874a53a7ba23525681f962
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046467048
64 https://doi.org/10.1007/s00384-013-1654-4
65 schema:sdDatePublished 2019-04-10T19:09
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N7f1b690b66bc4e72bdc85131765eb8ae
68 schema:url http://link.springer.com/10.1007%2Fs00384-013-1654-4
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N03d294db90b845b1a809ab69d2bb3426 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Young Adult
74 rdf:type schema:DefinedTerm
75 N0821bbfc430b4e60af0c98290a646006 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name RNA, Messenger
77 rdf:type schema:DefinedTerm
78 N0eae4fdf5a5e44569513c4ae5a549f35 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Colonoscopy
80 rdf:type schema:DefinedTerm
81 N11abbd02880c46859ed9a12ae5a3a081 rdf:first sg:person.01365030634.57
82 rdf:rest Nad5cdefd8f6441f2970cda39675534fc
83 N12d271af83be495bb31150b36a3e1ecb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Middle Aged
85 rdf:type schema:DefinedTerm
86 N13e050d35e8d447c8d500ba50f1debc3 rdf:first sg:person.01110014165.27
87 rdf:rest Nafaa0b453a454d77bbdec7e8186b763f
88 N17b6e2c594464b28b0abcf5cf926519d rdf:first sg:person.01035330071.27
89 rdf:rest Nf33793293e19460a83ca297b1218320c
90 N266ee84a264d4691869415b2cfe64f9d schema:name pubmed_id
91 schema:value 23377880
92 rdf:type schema:PropertyValue
93 N28e7254410544e6aa133c65e1d0b586a rdf:first sg:person.01300004547.06
94 rdf:rest Nc6a4440118ab490a97dfcd0700bd8204
95 N2eccc63a12344cb38b1af5dbd0177368 schema:name dimensions_id
96 schema:value pub.1046467048
97 rdf:type schema:PropertyValue
98 N37b3d067ac7f4fed8a707130d6242e7a schema:name nlm_unique_id
99 schema:value 8607899
100 rdf:type schema:PropertyValue
101 N44b738e0d5b1463081737b0433bce41d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Adult
103 rdf:type schema:DefinedTerm
104 N469b04e97ce542128d7f090c860ed819 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Male
106 rdf:type schema:DefinedTerm
107 N46d68665fb1b43db8d9954d9171ad7c1 schema:name readcube_id
108 schema:value dd59cebdf1a2a2da07fefd09bcf4f6d3052a13f9a6f9375b840ca2bdab0f1a7b
109 rdf:type schema:PropertyValue
110 N48093f9a741245aa919e38251d88c778 schema:issueNumber 8
111 rdf:type schema:PublicationIssue
112 N4bde1b432ede45e5924163505b2a3f8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Aged
114 rdf:type schema:DefinedTerm
115 N59cb5bdc94b54cd5900b5aaacb7a41a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Female
117 rdf:type schema:DefinedTerm
118 N6bc53956dc234dc6b58706862902307e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Gene Expression Regulation
120 rdf:type schema:DefinedTerm
121 N731f79c7e0b94c6d8ccc990a8a344207 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Odds Ratio
123 rdf:type schema:DefinedTerm
124 N7f1b690b66bc4e72bdc85131765eb8ae schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N90f2cd5f37e2499a997faab69059fd38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Colitis, Ulcerative
128 rdf:type schema:DefinedTerm
129 N97ad99f781864ad994ef17811e7c7c0a rdf:first sg:person.01231671347.04
130 rdf:rest Na13354371c2345f198623f6a07592c16
131 N98b165319ae64e96b89a3e532047b2a0 schema:volumeNumber 28
132 rdf:type schema:PublicationVolume
133 Na13354371c2345f198623f6a07592c16 rdf:first sg:person.0734300745.15
134 rdf:rest Nd82160e9a542407ca019ff41c086d239
135 Na168e35e203e4e99bd03c474dfa0570c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Gastrointestinal Hemorrhage
137 rdf:type schema:DefinedTerm
138 Nac45dfa223ac4a0dad0f0e09232bf7fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Inflammation
140 rdf:type schema:DefinedTerm
141 Nad5cdefd8f6441f2970cda39675534fc rdf:first sg:person.01300535632.67
142 rdf:rest Nc17178571a9c4a5bb879b471c05d3758
143 Nafaa0b453a454d77bbdec7e8186b763f rdf:first sg:person.01053170647.97
144 rdf:rest rdf:nil
145 Nb3e1ba2a7e924a838da75f7361ac2943 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Humans
147 rdf:type schema:DefinedTerm
148 Nc17178571a9c4a5bb879b471c05d3758 rdf:first sg:person.01346651032.11
149 rdf:rest N97ad99f781864ad994ef17811e7c7c0a
150 Nc414913b31f64d949fa7461d5d24f819 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Intestinal Mucosa
152 rdf:type schema:DefinedTerm
153 Nc5d81acb00e944bf934d7bdfabdc74d7 rdf:first sg:person.01332614216.53
154 rdf:rest N11abbd02880c46859ed9a12ae5a3a081
155 Nc6a4440118ab490a97dfcd0700bd8204 rdf:first sg:person.01012710761.94
156 rdf:rest Ncf2f5f3b38884ebbb62ba7e919b1f2dc
157 Ncf2f5f3b38884ebbb62ba7e919b1f2dc rdf:first sg:person.01353336467.04
158 rdf:rest Ne893f44de50f433597de26c199fb05ae
159 Nd4bf6f47da0b43d2b0809210d11edc84 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Tumor Necrosis Factor-alpha
161 rdf:type schema:DefinedTerm
162 Nd82160e9a542407ca019ff41c086d239 rdf:first sg:person.0670627047.38
163 rdf:rest N28e7254410544e6aa133c65e1d0b586a
164 Ndb637c99c0874a53a7ba23525681f962 schema:name doi
165 schema:value 10.1007/s00384-013-1654-4
166 rdf:type schema:PropertyValue
167 Ne4318230e6524d62b242249c5329642d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Aged, 80 and over
169 rdf:type schema:DefinedTerm
170 Ne893f44de50f433597de26c199fb05ae rdf:first sg:person.01041700765.08
171 rdf:rest N13e050d35e8d447c8d500ba50f1debc3
172 Nf33793293e19460a83ca297b1218320c rdf:first sg:person.01216365616.30
173 rdf:rest Nc5d81acb00e944bf934d7bdfabdc74d7
174 Nfc869cf49d1a41088e7d5b322db23812 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Logistic Models
176 rdf:type schema:DefinedTerm
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
181 schema:name Clinical Sciences
182 rdf:type schema:DefinedTerm
183 sg:journal.1096381 schema:issn 0179-1958
184 1432-1262
185 schema:name International Journal of Colorectal Disease
186 rdf:type schema:Periodical
187 sg:person.01012710761.94 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
188 schema:familyName Komoto
189 schema:givenName Shunsuke
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01012710761.94
191 rdf:type schema:Person
192 sg:person.01035330071.27 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
193 schema:familyName Hozumi
194 schema:givenName Hideaki
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035330071.27
196 rdf:type schema:Person
197 sg:person.01041700765.08 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
198 schema:familyName Kawaguchi
199 schema:givenName Atsushi
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041700765.08
201 rdf:type schema:Person
202 sg:person.01053170647.97 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
203 schema:familyName Miura
204 schema:givenName Soichiro
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053170647.97
206 rdf:type schema:Person
207 sg:person.01110014165.27 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
208 schema:familyName Nagao
209 schema:givenName Shigeaki
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01110014165.27
211 rdf:type schema:Person
212 sg:person.01216365616.30 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
213 schema:familyName Hokari
214 schema:givenName Ryota
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216365616.30
216 rdf:type schema:Person
217 sg:person.01231671347.04 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
218 schema:familyName Ueda
219 schema:givenName Toshihide
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231671347.04
221 rdf:type schema:Person
222 sg:person.01300004547.06 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
223 schema:familyName Watanabe
224 schema:givenName Chikako
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300004547.06
226 rdf:type schema:Person
227 sg:person.01300535632.67 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
228 schema:familyName Sato
229 schema:givenName Hirokazu
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01300535632.67
231 rdf:type schema:Person
232 sg:person.01332614216.53 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
233 schema:familyName Kurihara
234 schema:givenName Chie
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01332614216.53
236 rdf:type schema:Person
237 sg:person.01346651032.11 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
238 schema:familyName Sato
239 schema:givenName Shingo
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346651032.11
241 rdf:type schema:Person
242 sg:person.01353336467.04 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
243 schema:familyName Tomita
244 schema:givenName Kengo
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353336467.04
246 rdf:type schema:Person
247 sg:person.01365030634.57 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
248 schema:familyName Narimatsu
249 schema:givenName Kazuyuki
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365030634.57
251 rdf:type schema:Person
252 sg:person.0670627047.38 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
253 schema:familyName Okada
254 schema:givenName Yoshikiyo
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670627047.38
256 rdf:type schema:Person
257 sg:person.0734300745.15 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
258 schema:familyName Higashiyama
259 schema:givenName Masaaki
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734300745.15
261 rdf:type schema:Person
262 sg:pub.10.1007/bf02934086 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053459106
263 https://doi.org/10.1007/bf02934086
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/nature10209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011250403
266 https://doi.org/10.1038/nature10209
267 rdf:type schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1075051693 schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1076546633 schema:CreativeWork
270 https://app.dimensions.ai/details/publication/pub.1082991571 schema:CreativeWork
271 https://app.dimensions.ai/details/publication/pub.1083113462 schema:CreativeWork
272 https://doi.org/10.1016/0016-5085(94)90614-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018221919
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/0016-5085(95)90599-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044650773
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/1043-4666(90)90012-i schema:sameAs https://app.dimensions.ai/details/publication/pub.1047599043
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/j.cyto.2009.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052517958
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s0016-5085(98)70381-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000627345
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1053/gast.2002.31899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021117209
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1053/j.gastro.2006.03.054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044930424
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1053/j.gastro.2009.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014304165
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1056/nejmra020831 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004344000
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1056/nejmra1102942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026919634
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1097/00000478-200008000-00009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051679917
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1111/j.1549-8719.2001.tb00177.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053217658
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1136/gut.2006.115980 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031837511
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1136/gut.2010.224154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013261660
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1136/gut.45.6.856 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015066898
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1152/ajpendo.1998.275.1.e27 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083300047
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1161/01.str.0000195133.98378.4b schema:sameAs https://app.dimensions.ai/details/publication/pub.1040027274
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1227/01.neu.0000170439.89041.d6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049608614
307 rdf:type schema:CreativeWork
308 https://doi.org/10.2147/vhrm.s2700 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069103005
309 rdf:type schema:CreativeWork
310 https://www.grid.ac/institutes/grid.416614.0 schema:alternateName National Defense Medical College
311 schema:name Department of Internal Medicine, National Defense Medical College, 3-2, Namiki, Tokorozawa, 359-8513, Saitama, Japan
312 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...