A observational study of the efficacy and safety of capecitabine versus bolus infusional 5-fluorouracil in pre-operative chemoradiotherapy for locally advanced ... View Full Text


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Article Info

DATE

2012-01-19

AUTHORS

Chin-Fan Chen, Ming-Yii Huang, Chih-Jen Huang, Chan-Han Wu, Yung-Sung Yeh, Hsiang-Lin Tsai, Cheng-Jen Ma, Chien-Yu Lu, Shun-Jen Chang, Ming-Jenn Chen, Jaw-Yuan Wang

ABSTRACT

Background and objectivesThis study is to evaluate the safety and efficacy of preoperative radiotherapy (RT) combined with bolus infusional 5-fluorouracil (5-FU) or oral capecitabine in patients with locally advanced rectal cancer (LARC).Materials and methodsSeventy-four patients were retrospectively analyzed. Twenty-seven patients were treated with 5-FU (350 mg/m2 IV bolus) and leucovorin (20 mg/m2 IV bolus) for 5 days/week during week 1 and 5 of RT. Forty-seven patients were treated with capecitabine (850 mg/m2, twice daily for 5 days/week). Both groups received the same RT course (45–50.4 Gy/25 fractions, 5 days/week, for 5 weeks). Patients underwent surgery in 6 weeks after completion of the chemoradiotherapy. Data of the observational study were collected.ResultsGrade 3 or 4 toxicities occurred in 40.7% (5-FU) and 19.1% (capecitabine) of the patients (P = 0.044). Six patients in the 5-FU group (22.2%) and six patients in the capecitabine group (14%) achieved complete response. Primary tumor (T) downstaging were achieved in 51.9% (5-FU) and 69.8% (capecitabine) of the patients. The pathological ypT0-2 stage was 40.7% (5-FU) and 67.4% (capecitabine) (P = 0.028).ConclusionsIn consideration of the better ypT0-2 downstaging rate, less severe toxicities, and no need for indwelling intravenous device on oral capecitabine regimen, the administration of oral capecitabine with RT may be a more favorable option in the neoadjuvant treatment for LARC. More... »

PAGES

727-736

Journal

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00384-011-1377-3

DOI

http://dx.doi.org/10.1007/s00384-011-1377-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007371098

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22258885


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28 schema:description Background and objectivesThis study is to evaluate the safety and efficacy of preoperative radiotherapy (RT) combined with bolus infusional 5-fluorouracil (5-FU) or oral capecitabine in patients with locally advanced rectal cancer (LARC).Materials and methodsSeventy-four patients were retrospectively analyzed. Twenty-seven patients were treated with 5-FU (350 mg/m2 IV bolus) and leucovorin (20 mg/m2 IV bolus) for 5 days/week during week 1 and 5 of RT. Forty-seven patients were treated with capecitabine (850 mg/m2, twice daily for 5 days/week). Both groups received the same RT course (45–50.4 Gy/25 fractions, 5 days/week, for 5 weeks). Patients underwent surgery in 6 weeks after completion of the chemoradiotherapy. Data of the observational study were collected.ResultsGrade 3 or 4 toxicities occurred in 40.7% (5-FU) and 19.1% (capecitabine) of the patients (P = 0.044). Six patients in the 5-FU group (22.2%) and six patients in the capecitabine group (14%) achieved complete response. Primary tumor (T) downstaging were achieved in 51.9% (5-FU) and 69.8% (capecitabine) of the patients. The pathological ypT0-2 stage was 40.7% (5-FU) and 67.4% (capecitabine) (P = 0.028).ConclusionsIn consideration of the better ypT0-2 downstaging rate, less severe toxicities, and no need for indwelling intravenous device on oral capecitabine regimen, the administration of oral capecitabine with RT may be a more favorable option in the neoadjuvant treatment for LARC.
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34 schema:keywords ConclusionsIn consideration
35 LARC
36 MethodsSeventy-four patients
37 RT course
38 administration
39 advanced rectal cancer
40 background
41 bolus
42 cancer
43 capecitabine
44 capecitabine group
45 capecitabine regimen
46 chemoradiotherapy
47 complete response
48 completion
49 consideration
50 course
51 data
52 days/week
53 devices
54 efficacy
55 favorable option
56 group
57 intravenous devices
58 leucovorin
59 materials
60 need
61 neoadjuvant treatment
62 observational study
63 options
64 oral capecitabine
65 patients
66 pre-operative chemoradiotherapy
67 preoperative radiotherapy
68 primary tumor
69 radiotherapy
70 rate
71 rectal cancer
72 regimen
73 response
74 safety
75 safety of capecitabine
76 severe toxicity
77 stage
78 study
79 surgery
80 toxicity
81 treatment
82 tumors
83 week 1
84 weeks
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