Rebampide enema therapy as a treatment for patients with chronic radiation proctitis: initial treatment or when other methods of conservative ... View Full Text


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Article Info

DATE

2008-03-08

AUTHORS

Tae Oh Kim, Geun Am Song, Sun Mi Lee, Gwang Ha Kim, Jeong Heo, Dae Hwan Kang, Mong Cho

ABSTRACT

IntroductionRadiation proctitis is a common complication following radiation therapy for pelvic malignancies. There have been no formal trials of treatment for radiation proctitis and a variety of methods are currently used. We assessed the efficacy of rebamipide enema to control symptoms and proctoscopic findings from radiation proctitis.Materials and methodsFifteen patients with radiation proctitis were enrolled. Enemas containing 150 mg rebamipide per dosing were administered after morning bowel movement, and always prior to bedtime, twice daily for 4 weeks. The efficacy of treatment was assessed from clinical symptoms (Subjective Objective Management Analysis Scale for Rectal Toxicity) and endoscopic findings.ResultsThe mean bleeding score improved from 2.67 to 0.53 (P < 0.01). The mean symptom scores improved in those patients who had pain (0.40 to 0.13), tenesmus (0.40 to 0.20), and stool frequency (0.27 to 0.13). The mean improvement in telangiectasia scores (2.13 to 0.80, P < 0.01), bleeding point scores (1.80 to 0.27, P < 0.01), and friable mucosa scores (1.33 to 0.20, P < 0.01) were all statistically significant. No side effects were noted in any patients.ConclusionRebamipide enema therapy for radiation proctitis is a safe and effective treatment of radiation proctitis. We suggest the value of rebamipide enema in the treatment of radiation proctitis when other conservative management or first treatment has failed. More... »

PAGES

629-633

References to SciGraph publications

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  • 2005-12. Efficacy of Rebamipide Enemas in Active Distal Ulcerative Colitis and Proctitis: A Prospective Study Report in DIGESTIVE DISEASES AND SCIENCES
  • 1999-05. Natural History of Late Radiation Proctosigmoiditis Treated with Topical Sucralfate Suspension in DIGESTIVE DISEASES AND SCIENCES
  • 2002-07. Rebamipide Prevents Delay of Acetic Acid-Induced Gastric Ulcer Healing Caused by Helicobacter pylori Infection in Mongolian Gerbils in DIGESTIVE DISEASES AND SCIENCES
  • 2002-06. Local Gastric and Serum Concentrations of Rebamipide Following Oral Ingestion in Healthy Volunteers in DIGESTIVE DISEASES AND SCIENCES
  • 2005-10. Rebamipide Enemas–New Effective Treatment for Patients with Corticosteroid Dependent or Resistant Ulcerative Colitis in DIGESTIVE DISEASES AND SCIENCES
  • 2001-04-01. Successful and sustained treatment of chronic radiation proctitis with antioxidant vitamins E and C in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 1993-08. Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats in DIGESTIVE DISEASES AND SCIENCES
  • 2000-08. Rebamipide, an Antiulcer Drug, Prevents DSS-Induced Colitis Formation in Rats in DIGESTIVE DISEASES AND SCIENCES
  • 1991-01. Radiation-induced proctosigmoiditis in DIGESTIVE DISEASES AND SCIENCES
  • 1995-11. Rebamipide, novel prostaglandin-inducer, accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer comparison with cimetidine in DIGESTIVE DISEASES AND SCIENCES
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00384-008-0453-9

    DOI

    http://dx.doi.org/10.1007/s00384-008-0453-9

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18327596


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    31 schema:description IntroductionRadiation proctitis is a common complication following radiation therapy for pelvic malignancies. There have been no formal trials of treatment for radiation proctitis and a variety of methods are currently used. We assessed the efficacy of rebamipide enema to control symptoms and proctoscopic findings from radiation proctitis.Materials and methodsFifteen patients with radiation proctitis were enrolled. Enemas containing 150 mg rebamipide per dosing were administered after morning bowel movement, and always prior to bedtime, twice daily for 4 weeks. The efficacy of treatment was assessed from clinical symptoms (Subjective Objective Management Analysis Scale for Rectal Toxicity) and endoscopic findings.ResultsThe mean bleeding score improved from 2.67 to 0.53 (P < 0.01). The mean symptom scores improved in those patients who had pain (0.40 to 0.13), tenesmus (0.40 to 0.20), and stool frequency (0.27 to 0.13). The mean improvement in telangiectasia scores (2.13 to 0.80, P < 0.01), bleeding point scores (1.80 to 0.27, P < 0.01), and friable mucosa scores (1.33 to 0.20, P < 0.01) were all statistically significant. No side effects were noted in any patients.ConclusionRebamipide enema therapy for radiation proctitis is a safe and effective treatment of radiation proctitis. We suggest the value of rebamipide enema in the treatment of radiation proctitis when other conservative management or first treatment has failed.
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    45 conservative management
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    47 effect
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    49 efficacy
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    51 endoscopic findings
    52 enema
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    57 frequency
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    60 malignancy
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    70 point score
    71 proctitis
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    73 radiation proctitis
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    75 rebamipide
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