Endosonographic and manometric evaluation of internal anal sphincter in patients with chronic anal fissure and its correlation with clinical outcome ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-08

AUTHORS

Marta Pascual, Miguel Pera, Ricard Courtier, Mariá José Gil, David Parés, Sonia Puig, Montserrat Andreu, Luis Grande

ABSTRACT

BACKGROUND AND AIMS: Anorectal pressure studies have demonstrated internal anal sphincter (IAS) hypertonia in patients with chronic anal fissure. It is unknown however, if these changes in IAS function are associated with any abnormality in sphincter morphology. The first aim was to investigate the clinical characteristics and the manometric and endosonographic findings of the IAS in a cohort of patients with chronic anal fissure. The second aim was to investigate the association between these findings and the outcome with topical Glyceryl trinitrate (GTN) therapy. MATERIALS AND METHODS: All patients who presented with chronic anal fissure from November 1999 to May 2004 were included after failure of conservative therapy. Anorectal manometry and anal endosonography were performed before treatment with 0.2% GTN ointment twice daily was initiated. Patients were evaluated after 8 weeks. RESULTS: One hundred and twenty-four patients (66 women, mean age, 45.2 +/- 14.8 years) were included. Hypertonia of the IAS was found in 84 (68%) patients. The mean maximum IAS thickness was 3.6 +/- 0.76 mm (1.6-5.5). An abnormally thick IAS, adjusted by age, was observed in 113 (91.1%) patients. We found no correlation between resting pressure and IAS thickness (r = 0.074; p = 0.41). At 8 weeks, 52 patients (42%) had healed with complete symptoms resolution. No statistically significant differences were observed when clinical features and manometric and endosonographic findings were compared between healing and no-healing fissures. CONCLUSION: The majority of patients with chronic anal fissure present an abnormally thick IAS. Clinical, manometric and endosonographic features had no association with outcome after GTN treatment. More... »

PAGES

963-967

References to SciGraph publications

  • 1993-11. Sonographic, manometric, and myographic evaluation of the anal sphincters morphology and function in DISEASES OF THE COLON & RECTUM
  • 1997-02. Re-examination of clinical manifestations and response to therapy of fissure-in-ano in DISEASES OF THE COLON & RECTUM
  • 1994-05. Sustained internal sphincter hypertonia in patients with chronic anal fissure in DISEASES OF THE COLON & RECTUM
  • 2005-02. Digital Rectal Examination of Sphincter Pressures in Chronic Anal Fissure Is Unreliable in DISEASES OF THE COLON & RECTUM
  • 1994-07. Relationship between anal pressure and anodermal blood flow in DISEASES OF THE COLON & RECTUM
  • 1982-04. Anal sphincteric pressure in fissure-in-ano before and after lateral internal sphincterotomy in DISEASES OF THE COLON & RECTUM
  • 1982-09. The role of internal sphincter in chronic anal fissures in DISEASES OF THE COLON & RECTUM
  • 1992-09. Ultra slow wave pressure variations in the anal canal before and after lateral internal sphincterotomy in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2000-02. Glyceryl trinitrate for chronic anal fissure—Healing or headache? in DISEASES OF THE COLON & RECTUM
  • 1997-03. Anal endosonography and manometry in DISEASES OF THE COLON & RECTUM
  • 2001-06. Reasons for failure of glyceryl trinitrate treatment of chronic fissure-in-ano in DISEASES OF THE COLON & RECTUM
  • 2004-11. Different anal pressure profiles in patients with anal fissure in TECHNIQUES IN COLOPROCTOLOGY
  • 1993-09. Anal manometry in patients with fissure-in-ano before and after internal sphincterotomy in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2005-06. Manometric Effect of Topical Glyceryl Trinitrate and Its Impact on Chronic Anal Fissure Healing in DISEASES OF THE COLON & RECTUM
  • 1999-08. Glyceryl trinitrate ointment for the treatment of chronic anal fissure in DISEASES OF THE COLON & RECTUM
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00384-006-0251-1

    DOI

    http://dx.doi.org/10.1007/s00384-006-0251-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1023053094

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/17216217


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