Long-term effect of 5-fluorouracil enhanced by intermittent administration of polysaccharide K after curative resection of colon cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2004-03

AUTHORS

Katsuki Ito, Hiroaki Nakazato, Akihiko Koike, Hiroshi Takagi, Shigetoyo Saji, Shozo Baba, Masayoshi Mai, Jun-ichi Sakamoto, Yasuo Ohashi

ABSTRACT

BACKGROUND AND AIMS: The efficacy of a biological response modifier polysaccharide K in adjuvant immunochemotherapy was evaluated in primary colon cancer patients with macroscopic Dukes' C after curative resection. PATIENTS AND METHODS: Employing the minimization method using three factors (lymph node metastases, preoperative serum CEA level, and institution), 446 patients were allocated into groups P and C. Group P received immunochemotherapy, oral PSK (3 g per day) followed by oral 5-FU (200 mg/body per day), while group C received only intermittent chemotherapy, oral 5-FU (200 mg per day) followed by 4-week rest. Both groups received ten courses. RESULTS: Survival for cancer death was significantly higher in group P than in group C, but there was no difference in 7-year disease-free survival or overall survival had. CONCLUSION: Repeated alternating administration with PSK followed by 5-FU can improve survival for cancer death. More... »

PAGES

157-164

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00384-003-0532-x

DOI

http://dx.doi.org/10.1007/s00384-003-0532-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037654123

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/13680286


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adenocarcinoma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adjuvants, Immunologic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antimetabolites, Antineoplastic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteoglycans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Rate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Surgery 2, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Katsuki", 
        "id": "sg:person.012706443662.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012706443662.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Yokoyama Gastrointestinal Hospital, 3-11-20, Chiyoda, Naka-ku, 460-0012, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakazato", 
        "givenName": "Hiroaki", 
        "id": "sg:person.01127077120.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127077120.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.411234.1", 
          "name": [
            "Department of Surgery 1, Aichi Medical University, 21 Karimata, Yazako, Nagakute-cho, Aichi-gun, 480-1195, Aichi, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Koike", 
        "givenName": "Akihiko", 
        "id": "sg:person.01255553137.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255553137.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagoya University", 
          "id": "https://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Surgery 2, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takagi", 
        "givenName": "Hiroshi", 
        "id": "sg:person.01025204665.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025204665.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Gifu University", 
          "id": "https://www.grid.ac/institutes/grid.256342.4", 
          "name": [
            "Department of Surgery 2, Gifu University School of Medicine, 40 Tsukasa-machi, 500-8705, Gifu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saji", 
        "givenName": "Shigetoyo", 
        "id": "sg:person.011741467042.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011741467042.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hamamatsu University", 
          "id": "https://www.grid.ac/institutes/grid.411951.9", 
          "name": [
            "Department of Surgery 2, Hamamatsu University School of Medicine, 3600 Handa-cho, 431-3192, Hamamatsu, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baba", 
        "givenName": "Shozo", 
        "id": "sg:person.012070223732.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012070223732.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kanazawa University", 
          "id": "https://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, 920-0934, Kanazawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mai", 
        "givenName": "Masayoshi", 
        "id": "sg:person.01177205535.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177205535.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Aichi Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.410800.d", 
          "name": [
            "Department of Surgery, Aichi Prefectural Hospital, 18 Kuriyado, Kake-machi, 444-0011, Okazaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakamoto", 
        "givenName": "Jun-ichi", 
        "id": "sg:person.0673305153.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673305153.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Tokyo", 
          "id": "https://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Health Science, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohashi", 
        "givenName": "Yasuo", 
        "id": "sg:person.016471405272.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016471405272.86"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0192-0561(88)90128-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003581160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0192-0561(88)90128-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003581160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02050666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015547669", 
          "https://doi.org/10.1007/bf02050666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02050666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015547669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf02050666", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015547669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01517346", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027390102", 
          "https://doi.org/10.1007/bf01517346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-2478(92)90121-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030033752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-2478(92)90121-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030033752"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199002083220602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038786775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)90233-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040577158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(94)90233-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040577158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02221321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041116625", 
          "https://doi.org/10.1007/bf02221321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02221321", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041116625", 
          "https://doi.org/10.1007/bf02221321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s002620050454", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041314890", 
          "https://doi.org/10.1007/s002620050454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/sim.4780010204", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042510484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.1.5695.541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044549067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(00)02214-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047764604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19860801)58:3<603::aid-cncr2820580302>3.0.co;2-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052239913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/2529712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069975328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074597741", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077126518", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-5347(17)38539-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078050653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080083772", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082263078", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/oxfordjournals.jjco.a039761", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082427988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082432441", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082497696", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2004-03", 
    "datePublishedReg": "2004-03-01", 
    "description": "BACKGROUND AND AIMS: The efficacy of a biological response modifier polysaccharide K in adjuvant immunochemotherapy was evaluated in primary colon cancer patients with macroscopic Dukes' C after curative resection.\nPATIENTS AND METHODS: Employing the minimization method using three factors (lymph node metastases, preoperative serum CEA level, and institution), 446 patients were allocated into groups P and C. Group P received immunochemotherapy, oral PSK (3 g per day) followed by oral 5-FU (200 mg/body per day), while group C received only intermittent chemotherapy, oral 5-FU (200 mg per day) followed by 4-week rest. Both groups received ten courses.\nRESULTS: Survival for cancer death was significantly higher in group P than in group C, but there was no difference in 7-year disease-free survival or overall survival had.\nCONCLUSION: Repeated alternating administration with PSK followed by 5-FU can improve survival for cancer death.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00384-003-0532-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1096381", 
        "issn": [
          "0179-1958", 
          "1432-1262"
        ], 
        "name": "International Journal of Colorectal Disease", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "19"
      }
    ], 
    "name": "Long-term effect of 5-fluorouracil enhanced by intermittent administration of polysaccharide K after curative resection of colon cancer", 
    "pagination": "157-164", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b35f5eb145b47257e5d5e0f253b6e4679cd8230a5f72509e7b8ff8837a309ab2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "13680286"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8607899"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00384-003-0532-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1037654123"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00384-003-0532-x", 
      "https://app.dimensions.ai/details/publication/pub.1037654123"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T13:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00384-003-0532-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00384-003-0532-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00384-003-0532-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00384-003-0532-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00384-003-0532-x'


 

This table displays all metadata directly associated to this object as RDF triples.

289 TRIPLES      21 PREDICATES      71 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00384-003-0532-x schema:about N0f547bf357174512a271f784ad92c312
2 N116d4030ed8748d7b96fc7f00dd011fc
3 N233599f1cc4f49bca2c27b9274466cf7
4 N2dfa3f250e724d07bfe46f7d66e3cf1e
5 N31da5cd9d8a34912b3ac6862697e07e9
6 N4048522d950b46d6adef8eb2f9576424
7 N42d0c4d3503949328c5d502de4c04e4f
8 N515a18eea2804a95b7851a9bd4b5ff3e
9 N702c946475e6446aa259b3919a93ddc3
10 N785bbc171afa4e2cad98b879b3ff0e63
11 N81cba9d993ab4ee4a31adccd08a4e092
12 N8652e51b50a74642a989c5ab1b951f51
13 N8b45572b4a6a4b898e26a5e20b54cd47
14 N8e18022c6fa2412e9bf92ab82f84fa0e
15 N9f83cb48c0364a10baf37280db8527cc
16 Na894214c191a4548917a8c9b191b2cda
17 Nb09c3126f22b4907909b12bc25274113
18 Nce981b0849cf4b32a9951695399f0802
19 Nd016a2b3721c464e87eaffc26c4f207f
20 Nff9f63e84c1d410bb4a4616ae5d85c1d
21 anzsrc-for:11
22 anzsrc-for:1112
23 schema:author N5a4e27bc7a8d4f5c88eec7c966d211b0
24 schema:citation sg:pub.10.1007/bf01517346
25 sg:pub.10.1007/bf02050666
26 sg:pub.10.1007/bf02221321
27 sg:pub.10.1007/s002620050454
28 https://app.dimensions.ai/details/publication/pub.1074597741
29 https://app.dimensions.ai/details/publication/pub.1077126518
30 https://app.dimensions.ai/details/publication/pub.1080083772
31 https://app.dimensions.ai/details/publication/pub.1082263078
32 https://app.dimensions.ai/details/publication/pub.1082432441
33 https://app.dimensions.ai/details/publication/pub.1082497696
34 https://doi.org/10.1002/1097-0142(19860801)58:3<603::aid-cncr2820580302>3.0.co;2-k
35 https://doi.org/10.1002/sim.4780010204
36 https://doi.org/10.1007/bf02050666
37 https://doi.org/10.1016/0165-2478(92)90121-4
38 https://doi.org/10.1016/0192-0561(88)90128-2
39 https://doi.org/10.1016/s0022-5347(17)38539-7
40 https://doi.org/10.1016/s0140-6736(00)02214-5
41 https://doi.org/10.1016/s0140-6736(94)90233-x
42 https://doi.org/10.1056/nejm199002083220602
43 https://doi.org/10.1093/oxfordjournals.jjco.a039761
44 https://doi.org/10.1136/bmj.1.5695.541
45 https://doi.org/10.2307/2529712
46 schema:datePublished 2004-03
47 schema:datePublishedReg 2004-03-01
48 schema:description BACKGROUND AND AIMS: The efficacy of a biological response modifier polysaccharide K in adjuvant immunochemotherapy was evaluated in primary colon cancer patients with macroscopic Dukes' C after curative resection. PATIENTS AND METHODS: Employing the minimization method using three factors (lymph node metastases, preoperative serum CEA level, and institution), 446 patients were allocated into groups P and C. Group P received immunochemotherapy, oral PSK (3 g per day) followed by oral 5-FU (200 mg/body per day), while group C received only intermittent chemotherapy, oral 5-FU (200 mg per day) followed by 4-week rest. Both groups received ten courses. RESULTS: Survival for cancer death was significantly higher in group P than in group C, but there was no difference in 7-year disease-free survival or overall survival had. CONCLUSION: Repeated alternating administration with PSK followed by 5-FU can improve survival for cancer death.
49 schema:genre research_article
50 schema:inLanguage en
51 schema:isAccessibleForFree false
52 schema:isPartOf N1fa4ffa22198481c842e704b8c2ee093
53 Nf0230c5d716b4b4380b9a2300e7d4519
54 sg:journal.1096381
55 schema:name Long-term effect of 5-fluorouracil enhanced by intermittent administration of polysaccharide K after curative resection of colon cancer
56 schema:pagination 157-164
57 schema:productId N0af01197ecee437990196648734bd6d1
58 N102681be9be04436b6336bf0df89857d
59 N7429e065029a4dbf9e0cee852a41602f
60 N847ca3d854cc4c54915bf4297468827e
61 Necf0f0c8a1cb4575972bc9d6a21e2604
62 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037654123
63 https://doi.org/10.1007/s00384-003-0532-x
64 schema:sdDatePublished 2019-04-10T13:17
65 schema:sdLicense https://scigraph.springernature.com/explorer/license/
66 schema:sdPublisher N2af135f2aa4f4369869015c747b4a5ef
67 schema:url http://link.springer.com/10.1007%2Fs00384-003-0532-x
68 sgo:license sg:explorer/license/
69 sgo:sdDataset articles
70 rdf:type schema:ScholarlyArticle
71 N048b270497d64d67b36fa1fa795ae622 rdf:first sg:person.01255553137.21
72 rdf:rest N6c3e56ce90444d7385bc480a6f8cfbc3
73 N0af01197ecee437990196648734bd6d1 schema:name dimensions_id
74 schema:value pub.1037654123
75 rdf:type schema:PropertyValue
76 N0f547bf357174512a271f784ad92c312 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Neoplasm Metastasis
78 rdf:type schema:DefinedTerm
79 N102681be9be04436b6336bf0df89857d schema:name pubmed_id
80 schema:value 13680286
81 rdf:type schema:PropertyValue
82 N116d4030ed8748d7b96fc7f00dd011fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Survival Rate
84 rdf:type schema:DefinedTerm
85 N1fa4ffa22198481c842e704b8c2ee093 schema:volumeNumber 19
86 rdf:type schema:PublicationVolume
87 N233599f1cc4f49bca2c27b9274466cf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Follow-Up Studies
89 rdf:type schema:DefinedTerm
90 N2af135f2aa4f4369869015c747b4a5ef schema:name Springer Nature - SN SciGraph project
91 rdf:type schema:Organization
92 N2dfa3f250e724d07bfe46f7d66e3cf1e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Combined Modality Therapy
94 rdf:type schema:DefinedTerm
95 N31da5cd9d8a34912b3ac6862697e07e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Humans
97 rdf:type schema:DefinedTerm
98 N389787f76b644307925828b9bf6acb09 rdf:first sg:person.016471405272.86
99 rdf:rest rdf:nil
100 N4048522d950b46d6adef8eb2f9576424 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Female
102 rdf:type schema:DefinedTerm
103 N42d0c4d3503949328c5d502de4c04e4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Proteoglycans
105 rdf:type schema:DefinedTerm
106 N48dc1c475ce74d6c84c07c370a123097 schema:name Yokoyama Gastrointestinal Hospital, 3-11-20, Chiyoda, Naka-ku, 460-0012, Nagoya, Japan
107 rdf:type schema:Organization
108 N4b0cc8363ad340c09ee68b222b93ea01 rdf:first sg:person.0673305153.34
109 rdf:rest N389787f76b644307925828b9bf6acb09
110 N515a18eea2804a95b7851a9bd4b5ff3e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Adjuvants, Immunologic
112 rdf:type schema:DefinedTerm
113 N5a4e27bc7a8d4f5c88eec7c966d211b0 rdf:first sg:person.012706443662.39
114 rdf:rest Na9e60918f98c4ba6a12970f5b3102756
115 N6c3e56ce90444d7385bc480a6f8cfbc3 rdf:first sg:person.01025204665.30
116 rdf:rest N75f3ad7b0c0749b49b848d3014192dda
117 N702c946475e6446aa259b3919a93ddc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Antimetabolites, Antineoplastic
119 rdf:type schema:DefinedTerm
120 N7429e065029a4dbf9e0cee852a41602f schema:name doi
121 schema:value 10.1007/s00384-003-0532-x
122 rdf:type schema:PropertyValue
123 N75f3ad7b0c0749b49b848d3014192dda rdf:first sg:person.011741467042.39
124 rdf:rest N8081287c943e4a71b819d90b52b2c7fe
125 N785bbc171afa4e2cad98b879b3ff0e63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Disease-Free Survival
127 rdf:type schema:DefinedTerm
128 N8081287c943e4a71b819d90b52b2c7fe rdf:first sg:person.012070223732.10
129 rdf:rest Nc7ed09edf71f4e3db4cba33c42418973
130 N81cba9d993ab4ee4a31adccd08a4e092 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Neoplasm Staging
132 rdf:type schema:DefinedTerm
133 N847ca3d854cc4c54915bf4297468827e schema:name nlm_unique_id
134 schema:value 8607899
135 rdf:type schema:PropertyValue
136 N8652e51b50a74642a989c5ab1b951f51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Colorectal Neoplasms
138 rdf:type schema:DefinedTerm
139 N8b45572b4a6a4b898e26a5e20b54cd47 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Administration, Oral
141 rdf:type schema:DefinedTerm
142 N8e18022c6fa2412e9bf92ab82f84fa0e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Male
144 rdf:type schema:DefinedTerm
145 N9f83cb48c0364a10baf37280db8527cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Middle Aged
147 rdf:type schema:DefinedTerm
148 Na894214c191a4548917a8c9b191b2cda schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Neoplasm Invasiveness
150 rdf:type schema:DefinedTerm
151 Na9e60918f98c4ba6a12970f5b3102756 rdf:first sg:person.01127077120.62
152 rdf:rest N048b270497d64d67b36fa1fa795ae622
153 Nb09c3126f22b4907909b12bc25274113 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Adenocarcinoma
155 rdf:type schema:DefinedTerm
156 Nc7ed09edf71f4e3db4cba33c42418973 rdf:first sg:person.01177205535.73
157 rdf:rest N4b0cc8363ad340c09ee68b222b93ea01
158 Nce981b0849cf4b32a9951695399f0802 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Aged
160 rdf:type schema:DefinedTerm
161 Nd016a2b3721c464e87eaffc26c4f207f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Fluorouracil
163 rdf:type schema:DefinedTerm
164 Necf0f0c8a1cb4575972bc9d6a21e2604 schema:name readcube_id
165 schema:value b35f5eb145b47257e5d5e0f253b6e4679cd8230a5f72509e7b8ff8837a309ab2
166 rdf:type schema:PropertyValue
167 Nf0230c5d716b4b4380b9a2300e7d4519 schema:issueNumber 2
168 rdf:type schema:PublicationIssue
169 Nff9f63e84c1d410bb4a4616ae5d85c1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Treatment Outcome
171 rdf:type schema:DefinedTerm
172 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
173 schema:name Medical and Health Sciences
174 rdf:type schema:DefinedTerm
175 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
176 schema:name Oncology and Carcinogenesis
177 rdf:type schema:DefinedTerm
178 sg:journal.1096381 schema:issn 0179-1958
179 1432-1262
180 schema:name International Journal of Colorectal Disease
181 rdf:type schema:Periodical
182 sg:person.01025204665.30 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
183 schema:familyName Takagi
184 schema:givenName Hiroshi
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025204665.30
186 rdf:type schema:Person
187 sg:person.01127077120.62 schema:affiliation N48dc1c475ce74d6c84c07c370a123097
188 schema:familyName Nakazato
189 schema:givenName Hiroaki
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127077120.62
191 rdf:type schema:Person
192 sg:person.011741467042.39 schema:affiliation https://www.grid.ac/institutes/grid.256342.4
193 schema:familyName Saji
194 schema:givenName Shigetoyo
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011741467042.39
196 rdf:type schema:Person
197 sg:person.01177205535.73 schema:affiliation https://www.grid.ac/institutes/grid.9707.9
198 schema:familyName Mai
199 schema:givenName Masayoshi
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01177205535.73
201 rdf:type schema:Person
202 sg:person.012070223732.10 schema:affiliation https://www.grid.ac/institutes/grid.411951.9
203 schema:familyName Baba
204 schema:givenName Shozo
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012070223732.10
206 rdf:type schema:Person
207 sg:person.01255553137.21 schema:affiliation https://www.grid.ac/institutes/grid.411234.1
208 schema:familyName Koike
209 schema:givenName Akihiko
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255553137.21
211 rdf:type schema:Person
212 sg:person.012706443662.39 schema:affiliation https://www.grid.ac/institutes/grid.27476.30
213 schema:familyName Ito
214 schema:givenName Katsuki
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012706443662.39
216 rdf:type schema:Person
217 sg:person.016471405272.86 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
218 schema:familyName Ohashi
219 schema:givenName Yasuo
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016471405272.86
221 rdf:type schema:Person
222 sg:person.0673305153.34 schema:affiliation https://www.grid.ac/institutes/grid.410800.d
223 schema:familyName Sakamoto
224 schema:givenName Jun-ichi
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673305153.34
226 rdf:type schema:Person
227 sg:pub.10.1007/bf01517346 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027390102
228 https://doi.org/10.1007/bf01517346
229 rdf:type schema:CreativeWork
230 sg:pub.10.1007/bf02050666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015547669
231 https://doi.org/10.1007/bf02050666
232 rdf:type schema:CreativeWork
233 sg:pub.10.1007/bf02221321 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041116625
234 https://doi.org/10.1007/bf02221321
235 rdf:type schema:CreativeWork
236 sg:pub.10.1007/s002620050454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041314890
237 https://doi.org/10.1007/s002620050454
238 rdf:type schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1074597741 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1077126518 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1080083772 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1082263078 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1082432441 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1082497696 schema:CreativeWork
245 https://doi.org/10.1002/1097-0142(19860801)58:3<603::aid-cncr2820580302>3.0.co;2-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1052239913
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/sim.4780010204 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042510484
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1007/bf02050666 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015547669
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0165-2478(92)90121-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030033752
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0192-0561(88)90128-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003581160
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0022-5347(17)38539-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078050653
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s0140-6736(00)02214-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047764604
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0140-6736(94)90233-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040577158
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1056/nejm199002083220602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038786775
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1093/oxfordjournals.jjco.a039761 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082427988
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1136/bmj.1.5695.541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044549067
266 rdf:type schema:CreativeWork
267 https://doi.org/10.2307/2529712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069975328
268 rdf:type schema:CreativeWork
269 https://www.grid.ac/institutes/grid.256342.4 schema:alternateName Gifu University
270 schema:name Department of Surgery 2, Gifu University School of Medicine, 40 Tsukasa-machi, 500-8705, Gifu, Japan
271 rdf:type schema:Organization
272 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
273 schema:name Department of Health Science, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan
274 rdf:type schema:Organization
275 https://www.grid.ac/institutes/grid.27476.30 schema:alternateName Nagoya University
276 schema:name Department of Surgery 2, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan
277 rdf:type schema:Organization
278 https://www.grid.ac/institutes/grid.410800.d schema:alternateName Aichi Cancer Center
279 schema:name Department of Surgery, Aichi Prefectural Hospital, 18 Kuriyado, Kake-machi, 444-0011, Okazaki, Japan
280 rdf:type schema:Organization
281 https://www.grid.ac/institutes/grid.411234.1 schema:alternateName Aichi Medical University
282 schema:name Department of Surgery 1, Aichi Medical University, 21 Karimata, Yazako, Nagakute-cho, Aichi-gun, 480-1195, Aichi, Japan
283 rdf:type schema:Organization
284 https://www.grid.ac/institutes/grid.411951.9 schema:alternateName Hamamatsu University
285 schema:name Department of Surgery 2, Hamamatsu University School of Medicine, 3600 Handa-cho, 431-3192, Hamamatsu, Japan
286 rdf:type schema:Organization
287 https://www.grid.ac/institutes/grid.9707.9 schema:alternateName Kanazawa University
288 schema:name Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, 920-0934, Kanazawa, Japan
289 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...