Long-term effect of 5-fluorouracil enhanced by intermittent administration of polysaccharide K after curative resection of colon cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-09-12

AUTHORS

Katsuki Ito, Hiroaki Nakazato, Akihiko Koike, Hiroshi Takagi, Shigetoyo Saji, Shozo Baba, Masayoshi Mai, Jun-ichi Sakamoto, Yasuo Ohashi

ABSTRACT

Background and aimsThe efficacy of a biological response modifier polysaccharide K in adjuvant immunochemotherapy was evaluated in primary colon cancer patients with macroscopic Dukes' C after curative resection.Patients and methodsEmploying the minimization method using three factors (lymph node metastases, preoperative serum CEA level, and institution), 446 patients were allocated into groups P and C. Group P received immunochemotherapy, oral PSK (3 g per day) followed by oral 5-FU (200 mg/body per day), while group C received only intermittent chemotherapy, oral 5-FU (200 mg per day) followed by 4-week rest. Both groups received ten courses.ResultsSurvival for cancer death was significantly higher in group P than in group C, but there was no difference in 7-year disease-free survival or overall survival had.ConclusionRepeated alternating administration with PSK followed by 5-FU can improve survival for cancer death. More... »

PAGES

157-164

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00384-003-0532-x

DOI

http://dx.doi.org/10.1007/s00384-003-0532-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037654123

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/13680286


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