Prognostic significance of Bcl-2 and p53 expression in gastric cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-11

AUTHORS

Hyeon Kook Lee, Hye Seung Lee, Han-Kwang Yang, Woo Ho Kim, Kuhn Uk Lee, Kuk Jin Choe, Jin-Pok Kim

ABSTRACT

BACKGROUND AND AIMS: Apoptosis regulates cell death and influences cell proliferation and therefore may play an important role in development or growth of various malignant tumors. The Bcl-2 and p53 are closely linked in the regulation of apoptosis. We investigated the prognostic significance of Bcl-2 and p53 expression in patients with gastric cancer. PATIENTS AND METHODS: Immunohistochemistry was used to study Bcl-2 and p53 expression in 308 consecutive patients with gastric cancer. RESULTS: Bcl-2 expression was positive in 39 patients (12.7%) and showed a significant negative correlation with depth of invasion and lymph node metastasis. p53 expression was observed in 105 patients (34.1%) and was significantly associated with depth of invasion, lymph node metastasis, distant metastasis, and intestinal type. Patients with Bcl-2(+) tumors showed a trend to better 5-year survival rate (81%) than those with Bcl-2(-) negative tumors (71%). The 5-year survival rate in p53 positive cases (60%) was significantly lower than that in p53-negative cases (78%). In addition, p53 expression showed a significantly poorer prognosis in both diffuse and intestinal types. In multivariate analysis restricted to patients with R0 resection p53 expression was an independent prognostic factor (relative risk: 2.063). In combined assessment of p53 and Bcl-2 expression the group with p53(+)/Bcl-2(-) tumors showed significantly worse 5-year survival (57%) than the other groups, while best survival was seen in the group with p53(+)/Bcl-2(+) tumors (100%). CONCLUSION: p53 expression is an unfavorable prognostic factor in gastric cancer. Bcl-2 expression may have possible prognostic value when combined with p53 expression. More... »

PAGES

518-525

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00384-003-0491-2

DOI

http://dx.doi.org/10.1007/s00384-003-0491-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032628183

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12811476


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