Clinical significance of c-kit expression in biliary atresia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2001-11

AUTHORS

Abul Faiz Kabir Uddin Ahmed, Masaki Nio, Haruo Ohtani, Hiroshi Nagura, Ryoji Ohi

ABSTRACT

. The aim of the present study was to examine the clinical significance of c-kit expression in biliary atresia (BA) using formalin-fixed, paraffin-embedded sections from 21 patients with BA. Patients were divided into group I (n = 8) with good liver function; group II (n = 8) with moderate liver dysfunction; and group III (n = 5) with severe liver dysfunction. Choledochal cysts (CDC, n = 5) and normal liver samples (NL, n = 4) served as controls. The results were analyzed and compared among the groups. Most c-kit+ cells were present in the portal tracts, and their numbers in BA were significantly higher than in the controls (11.12 ± 1.64 vs 2.15 ± 0.15 [mean ± standard error], P = 0.02, BA vs CDC; 11.12 ± 1.64 vs 1.66 ± 0.52, P = 0.03, BA vs NL). Clinical correlation revealed a significantly higher number of c-kit+ cells in group III versus group I (18.10 ± 3.62 vs 8.86 ± 2.51, P = 0.02). These results suggest that c-kit overexpression is associated with an adverse clinical outcome in BA. More... »

PAGES

601-603

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s003830100002

DOI

http://dx.doi.org/10.1007/s003830100002

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018672630

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11727048


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