Prenatal predictors of mortality in fetuses with congenital diaphragmatic hernia: a systematic review and meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-09-14

AUTHORS

Kazunori Masahata, Masaya Yamoto, Satoshi Umeda, Kouji Nagata, Keita Terui, Makoto Fujii, Masayuki Shiraishi, Masahiro Hayakawa, Shoichiro Amari, Kouji Masumoto, Tadaharu Okazaki, Noboru Inamura, Katsuaki Toyoshima, Yuki Koike, Taizo Furukawa, Yuta Yazaki, Akiko Yokoi, Masayuki Endo, Yuko Tazuke, Hiroomi Okuyama, Noriaki Usui

ABSTRACT

PurposeThis study aimed to evaluate prenatal predictors of mortality in fetuses with congenital diaphragmatic hernia (CDH).MethodsA systematic literature search was performed to identify relevant observational studies that evaluated the ability of lung-to-head ratio (LHR), observed-to-expected LHR (o/e-LHR), observed-to-expected total fetal lung volume (o/e-TFLV), lung-to-thorax transverse area ratio (L/T ratio), intrathoracic herniation of the liver and the stomach, and side of diaphragmatic hernia, using a threshold for the prediction of mortality in fetuses with CDH. Study quality was assessed using the QUADAS-2 tool. Hierarchical summary receiver operating characteristic curves were constructed.ResultsA total of 50 articles were included in this meta-analysis. The QUADAS-2 tool identified a high risk of bias in more than one domain scored in all parameters. Among those parameters, the diagnostic odds ratio of mortality with o/e-LHR < 25%, o/e-TFLV < 25%, and L/T ratio < 0.08 were 11.98 [95% confidence interval (CI) 4.65–30.89], 11.14 (95% CI 5.19–23.89), and 10.28 (95% CI 3.38–31.31), respectively. The predictive values for mortality were similar between the presence of liver herniation and retrocardiac fetal stomach position.ConclusionsThis systematic review suggests that o/e-LHR, o/e-TFLV, and L/T ratio are equally good predictors of neonatal mortality in fetuses with isolated CDH. More... »

PAGES

1745-1757

Journal

TITLE

Pediatric Surgery International

ISSUE

12

VOLUME

38

Author Affiliations

  • Department of Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan
  • Department of Pediatric Surgery, Shizuoka Children’s Hospital, Shizuoka, Japan
  • Department of Pediatric Surgery, Osaka Women’s and Children’s Hospital, Izumi, Japan
  • Department of Pediatric Surgery, Kyushu University, Fukuoka, Japan
  • Department of Pediatric Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
  • Department of Health Science, Graduate School of Medicine, Osaka University, Suita, Japan
  • Osaka University Library, Suita, Japan
  • Division of Neonatology, Center for Maternal-Neonatal Care, Nagoya University Hospital, Nagoya, Japan
  • Division of Neonatology, National Center for Child Health and Development, Tokyo, Japan
  • Department of Pediatric Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
  • Department of Pediatric Surgery, Juntendo University Urayasu Hospital, Urayasu, Japan
  • Department of Pediatrics, Kindai University Faculty of Medicine, Osaka-Sayama, Japan
  • Departments of Neonatology, Kanagawa Children’s Medical Center, Yokohama, Japan
  • Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Japan
  • Department of Pediatric Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
  • Department of Pediatric General and Urogenital Surgery, Juntendo University School of Medicine, Tokyo, Japan
  • Departments of Pediatric Surgery, Kobe Children’s Medical Center, Kobe, Japan
  • Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00383-022-05232-w

    DOI

    http://dx.doi.org/10.1007/s00383-022-05232-w

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1150995720

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/36102982


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