Is the appendix a good organ to diagnose total colonic aganglionosis? View Full Text


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Article Info

DATE

2021-09-23

AUTHORS

Marina L. Reppucci, Michael A. Arnold, Mark Lovell, Karla Santos-Jasso, Jill Ketzer, Alberto Pena, Luis de la Torre, Andrea Bischoff

ABSTRACT

PurposeThe use of the appendix for diagnosis of Total Colonic Aganglionosis (TCA) remains controversial. This study aimed to categorize the presence of ganglion cells in the appendix and determine its reliability as a histological specimen for the diagnosis of TCA.MethodsThis was a combined retrospective and prospective study. Permanent histological specimens of normal appendices removed during appendectomy for malrotation or falsely presumed appendicitis, and from patients with short segment Hirschsprung’s disease (HD) or TCA were included. Permanent specimens of the appendix tip from Malone procedures were prospectively collected. All specimens were independently reviewed by two experienced pathologists in a standardized manner to assess for the presence of ganglion cells.ResultsA total of 112 appendices were evaluated. Nine came from patients with a diagnosis of TCA, and five from patients with HD. Ganglion cells were present in all specimens from patients with diagnoses other than TCA and were absent in all specimens from patients with TCA.ConclusionIn the correct clinical setting, the absence of ganglion cells in the appendix can allow for a reliable diagnosis of TCA. More... »

PAGES

1-6

References to SciGraph publications

  • 2008-01-01. Histopathological Diagnosis and Differential Diagnosis of Hirschsprung’s Disease in HIRSCHSPRUNG'S DISEASE AND ALLIED DISORDERS
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    http://scigraph.springernature.com/pub.10.1007/s00383-021-05023-9

    DOI

    http://dx.doi.org/10.1007/s00383-021-05023-9

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/34554294


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