Potential role of the PD-L1 expression and tumor-infiltrating lymphocytes on neuroblastoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2020-01-10

AUTHORS

Shogo Zuo, Masayuki Sho, Toshio Sawai, Hiromichi Kanehiro, Kosaku Maeda, Makiko Yoshida, Ryo Tsukada, Motonari Nomura, Hiroomi Okuyama

ABSTRACT

PurposeThe programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway has garnered much attention for its roles in clinical oncology. The aim of this study was to examine the clinical impact of the PD-L1 expression and tumor-infiltrating lymphocytes (TILs) on neuroblastoma.MethodsWe evaluated the PD-L1 expression and TIL status in 31 patients with neuroblastoma who underwent a biopsy or resection by an immunohistochemical analysis. Furthermore, we performed the serial analysis of the PD-L1 status before and after chemotherapy in 15 patients.ResultsAmong the 31 cases, 11 (35%) showed a positive PD-L1 expression. The survival analysis showed a trend toward an association between PD-L1 positivity and a decreased overall survival. PD-L1 positivity tended to be associated with higher levels of tumor markers. In the serial analysis of the PD-L1 status, positivity was noted in 8 of 15 patients before chemotherapy and 6 after chemotherapy. Notably, all four patients with a positive PD-L1 status both before and after chemotherapy had recurrence, and 3 of them died during the follow-up period.ConclusionOur findings suggest that the PD-L1 tumor expression might be a good biomarker for the treatment of neuroblastoma patients, especially for advanced neuroblastoma. More... »

PAGES

137-143

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00383-019-04616-9

DOI

http://dx.doi.org/10.1007/s00383-019-04616-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1124007454

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31925505


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