Physiological analysis of the effects of rikkunshito on acid and non-acid gastroesophageal reflux using pH-multichannel intraluminal impedance monitoring View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-07-30

AUTHORS

Hisayoshi Kawahara, Yuko Tazuke, Hideki Soh, Akihiro Yoneda, Masahiro Fukuzawa

ABSTRACT

PurposeTo clarify the effects of rikkunshito on acid reflux, non-acid reflux, and esophageal clearance in patients with gastroesophageal reflux disease (GERD).MethodsWe enrolled seven patients with vomiting and/or stridor (median 6 years; 1 month–17 years), with a percent total time of esophageal pH <4.0 (reflux index) over 4.0 %. Rikkunshito (TJ-43; Tsumura Co, Tokyo, Japan) was given in three divided doses before meals. We retrospectively investigated its efficacy using pH-multichannel intraluminal impedance before and 7 (6–10) days after starting treatment. Statistical analyses were conducted using Wilcoxon signed-rank test.ResultsIn the pH analyses alone, the median number of acid reflux episodes >5 min (14 versus 10, p = 0.046) and median acid-clearance time (184 versus 134 s, p = 0.03) decreased significantly, although median decrease in reflux index did not reach significance (16.0 versus 17.9 %, p = 0.06). In the combined impedance and pH analyses, the median number (36 versus 36, p = 0.03) and median duration (1.9 versus 1.1 %, p = 0.046) of acid reflux decreased significantly; non-acid reflux and bolus clearance time did not change.ConclusionRikkunshito effectively reduced acid reflux, but not esophageal clearance, in patients with GERD. More... »

PAGES

927-931

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00383-014-3565-z

DOI

http://dx.doi.org/10.1007/s00383-014-3565-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004560734

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25074732


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