Effects of tacrolimus and insulin in a liver regeneration model in growing animals with portal vein stenosis: immunohistochemical and molecular ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-04

AUTHORS

Ariane Nadia Backes, Ana Cristina Aoun Tannuri, Fabiane Neiva Backes, Amadeu Jose Rodrigues Queiroz, Maria Cecília Mendonça Coelho, Elenice Lima da Silva, Evandro Sobroza de Mello, Uenis Tannuri

ABSTRACT

The aim of the present investigation was to describe a new model of liver regeneration in growing rats with reduced portal flow. In addition, it was studied whether tacrolimus and insulin could have any pro-regenerative effect under such conditions. Ninety-five rats were divided into five groups: Group 1 (sham), abdominal incision without intervention; Group 2, 70% hepatectomy; Group 3, 70% hepatectomy + PV stenosis; Group 4, 70% hepatectomy + portal vein stenosis + insulin; and Group 5, 70% hepatectomy + portal vein stenosis + tacrolimus. The remnant liver lobes were harvested for analyses. The liver weight decreased in the PV stenosis group and it increased with the use of insulin and tacrolimus. The mitotic activity was higher in the hepatectomy, insulin and tacrolimus groups and this parameter was reduced by portal stenosis. Levels of interleukin 6 (IL-6) were higher in the hepatectomy group compared to the sham and PV stenosis groups. The expression of IL-6 and Ki67 was significantly increased in the insulin and tacrolimus groups compared to the portal stenosis group. A highly reproducible model was standardized to study liver regeneration with portal blood inflow reduction in weaning rats. It was demonstrated that insulin or tacrolimus administration may partially reverse the harmful effects of PV stenosis. More... »

PAGES

423-429

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00383-014-3464-3

DOI

http://dx.doi.org/10.1007/s00383-014-3464-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042502928

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24468714


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