Repeated injections of intradetrusor onabotulinumtoxinA as adjunctive treatment of children with neurogenic bladder View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-01

AUTHORS

Cristian Sager, Carol Burek, Juan Bortagaray, Juan Pablo Corbetta, Santiago Weller, Victor Durán, Juan Carlos Lopez

ABSTRACT

AIM: To evaluate the effects of repeated injections of onabotulinumtoxinA in children with neurogenic bladders refractory to conventional treatment. PATIENTS AND METHODS: A total of 26 children with neurogenic bladder were prospectively studied. Some patients received up to four repeat injections. Patients were reinjected if they showed improvement in voiding diary, score of urinary incontinence and/or urodynamic studies; otherwise, augmentation cystoplasty was indicated. RESULTS: Of the 26 patients, 12 were reinjected a second time, 6 patients were reinjected a third time and 2 patients received a repeat injection for the fourth time. Six months after the first, second and third injection, the urinary incontinence score 0 (dry) was 50, 77 and 75 %, respectively. After each injection, the mean bladder capacity in voiding diary and the mean maximum cystometric capacity increased. The mean detrusor pressure at the end of filling decreased. Only compliance after the first injection improved significantly. Detrusor overactivity (n: 4), improved during 3 months and reappeared in three children after the first injection, but at greater cystometric volumes. In the fourth case, it reappeared 11 months after the third injection. Five patients underwent cystoplasty. CONCLUSION: After treatment with onabotulinumtoxinA, urinary continence achieved was 50-77 %. There were favorable changes in urodynamic variables, but they were insufficient. Detrusor overactivity was attenuated, but did not disappear completely. More... »

PAGES

79-85

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00383-013-3365-x

DOI

http://dx.doi.org/10.1007/s00383-013-3365-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051405035

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23958929


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