Glutamine prevents intestinal mucosal injury induced by cyclophosphamide in rats View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12-09

AUTHORS

Mitsugu Owari, Masafumi Wasa, Takaharu Oue, Satoko Nose, Masahiro Fukuzawa

ABSTRACT

PurposeHigh doses of anticancer drugs often damage the intestinal mucosa. The purpose of the present study was to examine the effect of glutamine on mucosal damage induced by cyclophosphamide in a rat model, and to elucidate the mechanisms responsible for its protective effects.MethodRats were randomly assigned to one of the three experimental groups. Group A (control) (n = 8): intraperitoneal injection of saline, group B (n = 8): intraperitoneal injection of cyclophosphamide (300 mg/kg), group C (n = 8): intraperitoneal injection of cyclophosphamide (300 mg/kg) and oral glutamine (1.0 g/kg). After 3 days, the ileal segment was removed for morphological and the biochemical analyses. We also evaluated the level of mucosal apoptosis by the TUNEL method and enterocyte proliferation using bromodeoxyuridine (BrdU).ResultsMucosal atrophy was observed in group B but not in groups A or C. The mucosal wet weight, protein and glutathione levels were significantly decreased in group B compared with group A, and were increased significantly in group C compared with group B. While enterocyte proliferation significantly decreased and the apoptotic index significantly increased in group B compared with group A, a significant increase in the enterocyte proliferation and a significant decrease in apoptosis were observed in group C compared with group B.ConclusionsGlutamine prevented intestinal mucosal injury induced by cyclophosphamide via increased glutathione, decreased apoptosis and increased proliferation of intestinal epithelial cells. More... »

PAGES

299-303

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00383-011-3023-0

DOI

http://dx.doi.org/10.1007/s00383-011-3023-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027945693

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22159634


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Administration, Oral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Apoptosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Proliferation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclophosphamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Models, Animal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glutamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ileal Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ileum", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Situ Nick-End Labeling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intestinal Mucosa", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Wistar", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Owari", 
        "givenName": "Mitsugu", 
        "id": "sg:person.01355476537.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355476537.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wasa", 
        "givenName": "Masafumi", 
        "id": "sg:person.01362637723.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362637723.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oue", 
        "givenName": "Takaharu", 
        "id": "sg:person.01055510666.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055510666.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nose", 
        "givenName": "Satoko", 
        "id": "sg:person.01061231571.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061231571.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.136593.b", 
          "name": [
            "Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukuzawa", 
        "givenName": "Masahiro", 
        "id": "sg:person.01176624231.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176624231.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s10620-005-9058-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042851471", 
          "https://doi.org/10.1007/s10620-005-9058-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-12-09", 
    "datePublishedReg": "2011-12-09", 
    "description": "PurposeHigh doses of anticancer drugs often damage the intestinal mucosa. The purpose of the present study was to examine the effect of glutamine on mucosal damage induced by cyclophosphamide in a rat model, and to elucidate the mechanisms responsible for its protective effects.MethodRats were randomly assigned to one of the three experimental groups. Group A (control) (n\u00a0=\u00a08): intraperitoneal injection of saline, group B (n\u00a0=\u00a08): intraperitoneal injection of cyclophosphamide (300\u00a0mg/kg), group C (n\u00a0=\u00a08): intraperitoneal injection of cyclophosphamide (300\u00a0mg/kg) and oral glutamine (1.0\u00a0g/kg). After 3\u00a0days, the ileal segment was removed for morphological and the biochemical analyses. We also evaluated the level of mucosal apoptosis by the TUNEL method and enterocyte proliferation using bromodeoxyuridine (BrdU).ResultsMucosal atrophy was observed in group B but not in groups A or C. The mucosal wet weight, protein and glutathione levels were significantly decreased in group B compared with group A, and were increased significantly in group C compared with group B. While enterocyte proliferation significantly decreased and the apoptotic index significantly increased in group B compared with group A, a significant increase in the enterocyte proliferation and a significant decrease in apoptosis were observed in group C compared with group B.ConclusionsGlutamine prevented intestinal mucosal injury induced by cyclophosphamide via increased glutathione, decreased apoptosis and increased proliferation of intestinal epithelial cells.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00383-011-3023-0", 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6043246", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1096464", 
        "issn": [
          "0179-0358", 
          "1437-9813"
        ], 
        "name": "Pediatric Surgery International", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "28"
      }
    ], 
    "keywords": [
      "intestinal mucosal injury", 
      "group B", 
      "group A", 
      "intraperitoneal injection", 
      "group C", 
      "enterocyte proliferation", 
      "mucosal injury", 
      "mucosal wet weight", 
      "intestinal epithelial cells", 
      "effects of glutamine", 
      "mucosal damage", 
      "oral glutamine", 
      "ileal segment", 
      "group B.", 
      "rat model", 
      "mucosal apoptosis", 
      "intestinal mucosa", 
      "protective effect", 
      "cyclophosphamide", 
      "glutathione levels", 
      "apoptotic index", 
      "TUNEL method", 
      "epithelial cells", 
      "significant decrease", 
      "significant increase", 
      "experimental group", 
      "injury", 
      "anticancer drugs", 
      "injection", 
      "proliferation", 
      "apoptosis", 
      "wet weight", 
      "present study", 
      "biochemical analysis", 
      "glutamine", 
      "MethodRats", 
      "atrophy", 
      "mucosa", 
      "rats", 
      "doses", 
      "saline", 
      "drugs", 
      "bromodeoxyuridine", 
      "levels", 
      "days", 
      "glutathione", 
      "effect", 
      "cells", 
      "B.", 
      "group", 
      "damage", 
      "index", 
      "decrease", 
      "weight", 
      "protein", 
      "study", 
      "increase", 
      "mechanism", 
      "segments", 
      "purpose", 
      "analysis", 
      "method", 
      "model"
    ], 
    "name": "Glutamine prevents intestinal mucosal injury induced by cyclophosphamide in rats", 
    "pagination": "299-303", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027945693"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00383-011-3023-0"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22159634"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00383-011-3023-0", 
      "https://app.dimensions.ai/details/publication/pub.1027945693"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_543.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00383-011-3023-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00383-011-3023-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00383-011-3023-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00383-011-3023-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00383-011-3023-0'


 

This table displays all metadata directly associated to this object as RDF triples.

222 TRIPLES      21 PREDICATES      105 URIs      96 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00383-011-3023-0 schema:about N0592b18ecd554a6db07a639e152d7ea9
2 N18220ba96da84d539ce1511fab1c0c2b
3 N1ca04f91a3954a82b546ccfbedd649ea
4 N257add1597e84d4caee4ed15264a935d
5 N2935fc557aa14de5b14f7a88adea1d1a
6 N432b211e124741c7a49cf636965ca6b0
7 N5b8b0ce46a62428897eb953709806261
8 N7e054360ae85479096e116c22ab4b57c
9 N7f33055c1fe94997a04fbcacab4dc6cf
10 N80ee14dfdd344f51b69df73b466d6b82
11 N875e268ef5e14dfab3e8ded3d89aec6b
12 N9bd5342a63ff4ede83ea3740d7924c09
13 Nd84fa764b287433daa92dfda0ef54d9d
14 Ndf62f36e199848688f652368e4b9e85f
15 Nf1665c0a9dfa457d8e2d70f838bd543e
16 Nf2d04316ee6344949e1fe490e869f9ef
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Nc7cb95e18f294a879a3fa419ef03476d
20 schema:citation sg:pub.10.1007/s10620-005-9058-0
21 schema:datePublished 2011-12-09
22 schema:datePublishedReg 2011-12-09
23 schema:description PurposeHigh doses of anticancer drugs often damage the intestinal mucosa. The purpose of the present study was to examine the effect of glutamine on mucosal damage induced by cyclophosphamide in a rat model, and to elucidate the mechanisms responsible for its protective effects.MethodRats were randomly assigned to one of the three experimental groups. Group A (control) (n = 8): intraperitoneal injection of saline, group B (n = 8): intraperitoneal injection of cyclophosphamide (300 mg/kg), group C (n = 8): intraperitoneal injection of cyclophosphamide (300 mg/kg) and oral glutamine (1.0 g/kg). After 3 days, the ileal segment was removed for morphological and the biochemical analyses. We also evaluated the level of mucosal apoptosis by the TUNEL method and enterocyte proliferation using bromodeoxyuridine (BrdU).ResultsMucosal atrophy was observed in group B but not in groups A or C. The mucosal wet weight, protein and glutathione levels were significantly decreased in group B compared with group A, and were increased significantly in group C compared with group B. While enterocyte proliferation significantly decreased and the apoptotic index significantly increased in group B compared with group A, a significant increase in the enterocyte proliferation and a significant decrease in apoptosis were observed in group C compared with group B.ConclusionsGlutamine prevented intestinal mucosal injury induced by cyclophosphamide via increased glutathione, decreased apoptosis and increased proliferation of intestinal epithelial cells.
24 schema:genre article
25 schema:isAccessibleForFree false
26 schema:isPartOf Nc6e5c1fdacb2454e8846acf1230bb322
27 Ne2bd433c3c374231b72828a8c897037d
28 sg:journal.1096464
29 schema:keywords B.
30 MethodRats
31 TUNEL method
32 analysis
33 anticancer drugs
34 apoptosis
35 apoptotic index
36 atrophy
37 biochemical analysis
38 bromodeoxyuridine
39 cells
40 cyclophosphamide
41 damage
42 days
43 decrease
44 doses
45 drugs
46 effect
47 effects of glutamine
48 enterocyte proliferation
49 epithelial cells
50 experimental group
51 glutamine
52 glutathione
53 glutathione levels
54 group
55 group A
56 group B
57 group B.
58 group C
59 ileal segment
60 increase
61 index
62 injection
63 injury
64 intestinal epithelial cells
65 intestinal mucosa
66 intestinal mucosal injury
67 intraperitoneal injection
68 levels
69 mechanism
70 method
71 model
72 mucosa
73 mucosal apoptosis
74 mucosal damage
75 mucosal injury
76 mucosal wet weight
77 oral glutamine
78 present study
79 proliferation
80 protective effect
81 protein
82 purpose
83 rat model
84 rats
85 saline
86 segments
87 significant decrease
88 significant increase
89 study
90 weight
91 wet weight
92 schema:name Glutamine prevents intestinal mucosal injury induced by cyclophosphamide in rats
93 schema:pagination 299-303
94 schema:productId N41f4e6da79ac4109a4d232d481bb92fa
95 N923ffbeec8fb4883a292f66f9f198f42
96 Nada0c12fe19f40a4833706c17faa2ae9
97 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027945693
98 https://doi.org/10.1007/s00383-011-3023-0
99 schema:sdDatePublished 2022-12-01T06:29
100 schema:sdLicense https://scigraph.springernature.com/explorer/license/
101 schema:sdPublisher N01cea39c66b84f679acf746e106f781c
102 schema:url https://doi.org/10.1007/s00383-011-3023-0
103 sgo:license sg:explorer/license/
104 sgo:sdDataset articles
105 rdf:type schema:ScholarlyArticle
106 N01cea39c66b84f679acf746e106f781c schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N0592b18ecd554a6db07a639e152d7ea9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Apoptosis
110 rdf:type schema:DefinedTerm
111 N0dc7def4ac0149da8d03f6df0bc800b8 rdf:first sg:person.01061231571.05
112 rdf:rest N599c1a2196034e9db9358345db7d83f5
113 N18220ba96da84d539ce1511fab1c0c2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Rats
115 rdf:type schema:DefinedTerm
116 N1ca04f91a3954a82b546ccfbedd649ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Enterocytes
118 rdf:type schema:DefinedTerm
119 N257add1597e84d4caee4ed15264a935d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Animals
121 rdf:type schema:DefinedTerm
122 N2935fc557aa14de5b14f7a88adea1d1a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Administration, Oral
124 rdf:type schema:DefinedTerm
125 N2ac15481f827424f8b9632bc15699070 rdf:first sg:person.01055510666.50
126 rdf:rest N0dc7def4ac0149da8d03f6df0bc800b8
127 N41f4e6da79ac4109a4d232d481bb92fa schema:name pubmed_id
128 schema:value 22159634
129 rdf:type schema:PropertyValue
130 N432b211e124741c7a49cf636965ca6b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Glutamine
132 rdf:type schema:DefinedTerm
133 N599c1a2196034e9db9358345db7d83f5 rdf:first sg:person.01176624231.59
134 rdf:rest rdf:nil
135 N5b8b0ce46a62428897eb953709806261 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Rats, Wistar
137 rdf:type schema:DefinedTerm
138 N7e054360ae85479096e116c22ab4b57c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Male
140 rdf:type schema:DefinedTerm
141 N7e7b3d509b3d471db61a150112f41110 rdf:first sg:person.01362637723.15
142 rdf:rest N2ac15481f827424f8b9632bc15699070
143 N7f33055c1fe94997a04fbcacab4dc6cf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Treatment Outcome
145 rdf:type schema:DefinedTerm
146 N80ee14dfdd344f51b69df73b466d6b82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Cyclophosphamide
148 rdf:type schema:DefinedTerm
149 N875e268ef5e14dfab3e8ded3d89aec6b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name In Situ Nick-End Labeling
151 rdf:type schema:DefinedTerm
152 N923ffbeec8fb4883a292f66f9f198f42 schema:name doi
153 schema:value 10.1007/s00383-011-3023-0
154 rdf:type schema:PropertyValue
155 N9bd5342a63ff4ede83ea3740d7924c09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Cell Proliferation
157 rdf:type schema:DefinedTerm
158 Nada0c12fe19f40a4833706c17faa2ae9 schema:name dimensions_id
159 schema:value pub.1027945693
160 rdf:type schema:PropertyValue
161 Nc6e5c1fdacb2454e8846acf1230bb322 schema:issueNumber 3
162 rdf:type schema:PublicationIssue
163 Nc7cb95e18f294a879a3fa419ef03476d rdf:first sg:person.01355476537.53
164 rdf:rest N7e7b3d509b3d471db61a150112f41110
165 Nd84fa764b287433daa92dfda0ef54d9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Disease Models, Animal
167 rdf:type schema:DefinedTerm
168 Ndf62f36e199848688f652368e4b9e85f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Intestinal Mucosa
170 rdf:type schema:DefinedTerm
171 Ne2bd433c3c374231b72828a8c897037d schema:volumeNumber 28
172 rdf:type schema:PublicationVolume
173 Nf1665c0a9dfa457d8e2d70f838bd543e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Ileal Diseases
175 rdf:type schema:DefinedTerm
176 Nf2d04316ee6344949e1fe490e869f9ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Ileum
178 rdf:type schema:DefinedTerm
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
183 schema:name Clinical Sciences
184 rdf:type schema:DefinedTerm
185 sg:grant.6043246 http://pending.schema.org/fundedItem sg:pub.10.1007/s00383-011-3023-0
186 rdf:type schema:MonetaryGrant
187 sg:journal.1096464 schema:issn 0179-0358
188 1437-9813
189 schema:name Pediatric Surgery International
190 schema:publisher Springer Nature
191 rdf:type schema:Periodical
192 sg:person.01055510666.50 schema:affiliation grid-institutes:grid.136593.b
193 schema:familyName Oue
194 schema:givenName Takaharu
195 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01055510666.50
196 rdf:type schema:Person
197 sg:person.01061231571.05 schema:affiliation grid-institutes:grid.136593.b
198 schema:familyName Nose
199 schema:givenName Satoko
200 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061231571.05
201 rdf:type schema:Person
202 sg:person.01176624231.59 schema:affiliation grid-institutes:grid.136593.b
203 schema:familyName Fukuzawa
204 schema:givenName Masahiro
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176624231.59
206 rdf:type schema:Person
207 sg:person.01355476537.53 schema:affiliation grid-institutes:grid.136593.b
208 schema:familyName Owari
209 schema:givenName Mitsugu
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01355476537.53
211 rdf:type schema:Person
212 sg:person.01362637723.15 schema:affiliation grid-institutes:grid.136593.b
213 schema:familyName Wasa
214 schema:givenName Masafumi
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362637723.15
216 rdf:type schema:Person
217 sg:pub.10.1007/s10620-005-9058-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042851471
218 https://doi.org/10.1007/s10620-005-9058-0
219 rdf:type schema:CreativeWork
220 grid-institutes:grid.136593.b schema:alternateName Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan
221 schema:name Department of Surgery, Division of Pediatric Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan
222 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...