Effects of rikkunshito on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-08-01

AUTHORS

Hisayoshi Kawahara, Akio Kubota, Toshimichi Hasegawa, Hiroomi Okuyama, Takehisa Ueno, Shinobu Ida, Masahiro Fukuzawa

ABSTRACT

Rikkunshito (TJ-43), a herbal medicine consisting of eight herbs, is used to treat chronic dyspepsia. Studies have shown that TJ-43 improves human gastric emptying. This study investigated the effects of TJ-43 on the clinical symptoms and esophageal acid exposure in children with symptomatic gastroesophageal reflux (GER). Eight children, aged from 2 months to 15 years (median age 4 years), were studied. Six of them had neurological impairment. TJ-43 (0.3 g/kg/day) was given orally or via nasogastric tubes in three divided doses before meals for 7 days. Their symptoms were frequent emesis in four, nausea in two, and hematemesis and stridor in one each. Twenty-four-hour esophageal pH monitoring was conducted using multichannel pH electrodes located at the distal esophagus (P1) and 10 cm proximal to P1 (P2). The clinical symptoms and esophageal pH were compared before and after TJ-43 therapy for 1 week. The frequency of emesis decreased in three patients. Other symptoms, including nausea, hematemesis, and stridor, were relieved in the remaining patients. Measured at the distal pH electrode, the percentage time of esophageal pH < 4.0 and the mean duration of reflux decreased significantly (P < 0.05). However, the number of acid reflux per hour did not change significantly, and no pH parameters measured at the proximal electrode differed significantly. The short-term administration of TJ-43 relieved symptoms and reduced the distal esophageal acid exposure through improved esophageal acid clearance. More... »

PAGES

1001-1005

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00383-007-1986-7

DOI

http://dx.doi.org/10.1007/s00383-007-1986-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1008230091

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17668223


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