A germline variant of TP53 in paediatric diffuse leptomeningeal glioneuronal tumour View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-02

AUTHORS

Grace I. L. Tan, Khurshid Merchant, Enrica E. K. Tan, David C. Y. Low, Lee Ping NG, Wan Tew Seow, Sharon Y. Y. Low

ABSTRACT

PURPOSE: Diffuse leptomeningeal glioneuronal tumour (DLGNT) is an extremely rare tumour involving the neuroaxis. At present, its exact pathogenesis and associated factors remain incompletely characterised. Recent molecular investigations in a small cohort have offered some insights into this disease. However, the role of germline findings has not yet been fully explored in affected patients. The authors present a case of DLGNT, focusing on the clinical and molecular features with reference to current disease knowledge. METHODS: A 4-year-old male presented with raised intracranial pressure symptoms secondary to extensive leptomeningeal disease of the brain and spine. Preliminary impression was that of an inflammatory lesion. RESULTS: A lumbar biopsy of the lesion confirmed DLGNT on routine diagnostic examination. Further molecular analysis of his tumour and blood demonstrated a previously unreported TP53 exon 5 (c.147V > I) germline variant. Based on the latest DLGNT molecular subtyping classification, his tumour falls into the group with better clinical outcome. However, his germline findings may add an extra layer of uncertainty to his overall prognosis. CONCLUSION: Given that much remains unknown in many rare paediatric tumours at this stage, isolated findings found in an individual may be of significance. Supplementary genetic information, together with tumour molecular analysis, add to our current understanding of this uncommon disease. This case highlights the benefit of combined clinical and molecular efforts, including germline testing, especially for children affected by such challenging neoplasms. More... »

PAGES

1-7

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00381-019-04128-w

DOI

http://dx.doi.org/10.1007/s00381-019-04128-w

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113176772

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30937530


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