Ontology type: schema:ScholarlyArticle
2015-01
AUTHORSTamir Ailon, Christopher Dunham, Anne-Sophie Carret, Uri Tabori, P. Daniel Mcneely, Shayna Zelcer, Beverley Wilson, Lucie Lafay-Cousin, Donna Johnston, David D. Eisenstat, Marianna Silva, Nada Jabado, Karen Jane Goddard, Chris Fryer, Glenda Hendson, Cynthia Hawkins, Sandra Dunn, Stephen Yip, Ashutosh Singhal, Juliette Hukin
ABSTRACTPURPOSE: Gross total resection (GTR) of intracranial ependymoma is an accepted goal. More controversial is radiotherapy deferral. This study reports on children treated with gross total resection who did not receive upfront adjuvant radiotherapy. METHODS: We conducted a retrospective review of children with intracranial ependymoma in 12 Canadian centers. Patients who had GTR of their tumor and no upfront radiotherapy were identified. Immunostaining was performed for Ki-67, epidermal growth factor receptor (EGFR), and EZH2 on archived tissue. The Kaplan-Meier survival analysis was performed and compared with those who had GTR followed by radiation. RESULTS: Twenty-six children were identified treated with GTR alone at diagnosis; 12 posterior fossa ependymoma (PFE) WHO grade II, and 14 supratentorial ependymoma (STE). Progression-free survival (PFS) in ependymoma treated with GTR alone at diagnosis was inferior in those with high Ki-67 or positive EZH2 immunostaining. Survival was inferior for patients less than 2 years old at diagnosis (p = 0.002). Survival was comparable to PFE WHO grade II and STE who had GTR followed by radiation (p = 0.62). Five-year PFS and overall survival (OS) of those treated with GTR alone were 60 and 70% respectively for PFE and 45 and 70% respectively for STE (p = 0.2; 0.55). CONCLUSIONS: This study suggests that there is a subset of children with certain biologic features who, in the setting of a prospective clinical trial, might be candidates for observation following GTR. Good risk factors for this approach include age of 2 years or older, low Ki-67, and negative EZH2. If relapse occurs, it may be confined to the primary site, allowing for possible salvage with GTR followed by XRT. More... »
PAGES57-65
http://scigraph.springernature.com/pub.10.1007/s00381-014-2575-4
DOIhttp://dx.doi.org/10.1007/s00381-014-2575-4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1035724779
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25391979
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adolescent",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Brain Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Canada",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Child, Preschool",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Community Health Planning",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Enhancer of Zeste Homolog 2 Protein",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ependymoma",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kaplan-Meier Estimate",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ki-67 Antigen",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neurosurgery",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polycomb Repressive Complex 2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radiotherapy, Adjuvant",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptor, Epidermal Growth Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Retrospective Studies",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "British Columbia Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.414137.4",
"name": [
"Division of Neurology and Oncology, Department of Pediatrics, British Columbia Children\u2019s Hospital, Room K3-147, 4480 Oak Street, V6H3 V4, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Ailon",
"givenName": "Tamir",
"id": "sg:person.0756354121.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756354121.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "British Columbia Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.414137.4",
"name": [
"Division of Neurology and Oncology, Department of Pediatrics, British Columbia Children\u2019s Hospital, Room K3-147, 4480 Oak Street, V6H3 V4, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Dunham",
"givenName": "Christopher",
"id": "sg:person.0577243620.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577243620.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Universitaire Sainte-Justine",
"id": "https://www.grid.ac/institutes/grid.411418.9",
"name": [
"CHU Sainte-Justine, 3175, chemin C\u00f4te Sainte-Catherine, H3T 1C5, Montreal, QC, Canada"
],
"type": "Organization"
},
"familyName": "Carret",
"givenName": "Anne-Sophie",
"id": "sg:person.01347007145.61",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01347007145.61"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hospital for Sick Children",
"id": "https://www.grid.ac/institutes/grid.42327.30",
"name": [
"The Hospital for Sick Children, 555 University Ave, M5G 1X8, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Tabori",
"givenName": "Uri",
"id": "sg:person.01231232151.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231232151.14"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Izaak Walton Killam Health Centre",
"id": "https://www.grid.ac/institutes/grid.414870.e",
"name": [
"IWK Health Centre, 5850 University Ave, PO Box 9700, B3K 6R8, Halifax, NS, Canada"
],
"type": "Organization"
},
"familyName": "Mcneely",
"givenName": "P. Daniel",
"id": "sg:person.01176515413.70",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01176515413.70"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "London Health Sciences Centre",
"id": "https://www.grid.ac/institutes/grid.412745.1",
"name": [
"Children\u2019s Hospital, London Health Sciences Centre, 800 Commissioners Road East, N6A 5 W9, London, ON, Canada"
],
"type": "Organization"
},
"familyName": "Zelcer",
"givenName": "Shayna",
"id": "sg:person.01025452641.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025452641.81"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Stollery Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.416656.6",
"name": [
"Stollery Children\u2019s Hospital, Aberhart Centre One, 11402 University Avenue, Room 7325A, T6G 2 J3, Edmonton, AB, Canada"
],
"type": "Organization"
},
"familyName": "Wilson",
"givenName": "Beverley",
"id": "sg:person.0577467314.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577467314.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Alberta Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.413571.5",
"name": [
"Alberta Children\u2019s Hospital, 2888 Shaganappi Trail NW, T3B 6A8, Calgary, AB, Canada"
],
"type": "Organization"
},
"familyName": "Lafay-Cousin",
"givenName": "Lucie",
"id": "sg:person.0726340504.86",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726340504.86"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Children's Hospital of Eastern Ontario",
"id": "https://www.grid.ac/institutes/grid.414148.c",
"name": [
"Children\u2019s Hospital of Eastern Ontario, 401 Smyth Road, K1H 8 L1, Ottawa, ON, Canada"
],
"type": "Organization"
},
"familyName": "Johnston",
"givenName": "Donna",
"id": "sg:person.0632266264.57",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632266264.57"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Manitoba Cancer Center, 675 McDermot Avenue, R3E 0V9, Winnipeg, MB, Canada"
],
"type": "Organization"
},
"familyName": "Eisenstat",
"givenName": "David D.",
"id": "sg:person.01046603671.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01046603671.45"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kingston General Hospital",
"id": "https://www.grid.ac/institutes/grid.415354.2",
"name": [
"Kingston General Hospital, 76 Stuart Street, Burr 1 Room 21-1058, K7L 2 V7, Kingston, ON, Canada"
],
"type": "Organization"
},
"familyName": "Silva",
"givenName": "Marianna",
"id": "sg:person.0717737411.90",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0717737411.90"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Montreal Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.416084.f",
"name": [
"Montreal Children\u2019s Hospital, 2300 Rue Tupper, H3H 1P3, Montreal, QC, Canada"
],
"type": "Organization"
},
"familyName": "Jabado",
"givenName": "Nada",
"id": "sg:person.01150751514.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01150751514.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"British Columbia Cancer Agency, 600 West 10th Avenue, V5Z 4E6, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Goddard",
"givenName": "Karen Jane",
"id": "sg:person.01122720174.64",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122720174.64"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "British Columbia Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.414137.4",
"name": [
"Division of Neurology and Oncology, Department of Pediatrics, British Columbia Children\u2019s Hospital, Room K3-147, 4480 Oak Street, V6H3 V4, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Fryer",
"givenName": "Chris",
"id": "sg:person.01320401741.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320401741.24"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "British Columbia Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.414137.4",
"name": [
"Division of Neurology and Oncology, Department of Pediatrics, British Columbia Children\u2019s Hospital, Room K3-147, 4480 Oak Street, V6H3 V4, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Hendson",
"givenName": "Glenda",
"id": "sg:person.0635713542.95",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635713542.95"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hospital for Sick Children",
"id": "https://www.grid.ac/institutes/grid.42327.30",
"name": [
"The Hospital for Sick Children, 555 University Ave, M5G 1X8, Toronto, ON, Canada"
],
"type": "Organization"
},
"familyName": "Hawkins",
"givenName": "Cynthia",
"id": "sg:person.01303036367.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303036367.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Child and Family Research Institute",
"id": "https://www.grid.ac/institutes/grid.418502.a",
"name": [
"Child and Family Research Institute, 950 West 28th Avenue, V5Z 4H4, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Dunn",
"givenName": "Sandra",
"id": "sg:person.011635755417.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011635755417.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "BC Cancer Agency",
"id": "https://www.grid.ac/institutes/grid.248762.d",
"name": [
"British Columbia Cancer Agency, 600 West 10th Avenue, V5Z 4E6, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Yip",
"givenName": "Stephen",
"id": "sg:person.0745471507.67",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745471507.67"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "British Columbia Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.414137.4",
"name": [
"Division of Neurology and Oncology, Department of Pediatrics, British Columbia Children\u2019s Hospital, Room K3-147, 4480 Oak Street, V6H3 V4, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Singhal",
"givenName": "Ashutosh",
"id": "sg:person.01107770635.66",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01107770635.66"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "British Columbia Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.414137.4",
"name": [
"Division of Neurology and Oncology, Department of Pediatrics, British Columbia Children\u2019s Hospital, Room K3-147, 4480 Oak Street, V6H3 V4, Vancouver, BC, Canada"
],
"type": "Organization"
},
"familyName": "Hukin",
"givenName": "Juliette",
"id": "sg:person.01066370542.69",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066370542.69"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1200/jco.2007.15.9970",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000804605"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000028683",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001835884"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ccr.2011.07.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002356005"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/mpo.2950200302",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003820974"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11060-011-0624-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004478725",
"https://doi.org/10.1007/s11060-011-0624-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0360-3016(92)90747-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005290663"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s003810050244",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007080664",
"https://doi.org/10.1007/s003810050244"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s003810050487",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007538934",
"https://doi.org/10.1007/s003810050487"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0360-3016(00)01353-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009314219"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1096-911x(199708)29:2<79::aid-mpo3>3.0.co;2-o",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014337274"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00381-008-0799-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014399610",
"https://doi.org/10.1007/s00381-008-0799-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00381-008-0799-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014399610",
"https://doi.org/10.1007/s00381-008-0799-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199301143280203",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019624689"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1470-2045(08)70342-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025867846"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/(sici)1096-911x(199806)30:6<319::aid-mpo1>3.0.co;2-h",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030964158"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1227/00006123-199105000-00005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036488171"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ijrobp.2013.12.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041177463"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.critrevonc.2007.03.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042704807"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1016222202230",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044139196",
"https://doi.org/10.1023/a:1016222202230"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf01053933",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046867168",
"https://doi.org/10.1007/bf01053933"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1227/00006123-199302000-00003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064432398"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1990.72.3.0408",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071095672"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1990.72.3.0408",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071095672"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1990.72.3.0408",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071095672"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1998.88.4.0695",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071098751"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1998.88.4.0695",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071098751"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.1998.88.4.0695",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071098751"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3171/jns.2005.103.1.0031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071101653"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.1995.13.9.2263",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082457317"
],
"type": "CreativeWork"
}
],
"datePublished": "2015-01",
"datePublishedReg": "2015-01-01",
"description": "PURPOSE: Gross total resection (GTR) of intracranial ependymoma is an accepted goal. More controversial is radiotherapy deferral. This study reports on children treated with gross total resection who did not receive upfront adjuvant radiotherapy.\nMETHODS: We conducted a retrospective review of children with intracranial ependymoma in 12 Canadian centers. Patients who had GTR of their tumor and no upfront radiotherapy were identified. Immunostaining was performed for Ki-67, epidermal growth factor receptor (EGFR), and EZH2 on archived tissue. The Kaplan-Meier survival analysis was performed and compared with those who had GTR followed by radiation.\nRESULTS: Twenty-six children were identified treated with GTR alone at diagnosis; 12 posterior fossa ependymoma (PFE) WHO grade II, and 14 supratentorial ependymoma (STE). Progression-free survival (PFS) in ependymoma treated with GTR alone at diagnosis was inferior in those with high Ki-67 or positive EZH2 immunostaining. Survival was inferior for patients less than 2 years old at diagnosis (p\u2009=\u20090.002). Survival was comparable to PFE WHO grade II and STE who had GTR followed by radiation (p\u2009=\u20090.62). Five-year PFS and overall survival (OS) of those treated with GTR alone were 60 and 70% respectively for PFE and 45 and 70% respectively for STE (p\u2009=\u20090.2; 0.55).\nCONCLUSIONS: This study suggests that there is a subset of children with certain biologic features who, in the setting of a prospective clinical trial, might be candidates for observation following GTR. Good risk factors for this approach include age of 2 years or older, low Ki-67, and negative EZH2. If relapse occurs, it may be confined to the primary site, allowing for possible salvage with GTR followed by XRT.",
"genre": "research_article",
"id": "sg:pub.10.1007/s00381-014-2575-4",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1095355",
"issn": [
"0256-7040",
"1433-0350"
],
"name": "Child's Nervous System",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "31"
}
],
"name": "The role of resection alone in select children with intracranial ependymoma: the Canadian Pediatric Brain Tumour Consortium experience",
"pagination": "57-65",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"aa2de89c82ff16837f8be7893bb8de64300a22f7c6cad476f981f6c5737af6e3"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25391979"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8503227"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00381-014-2575-4"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1035724779"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00381-014-2575-4",
"https://app.dimensions.ai/details/publication/pub.1035724779"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T17:32",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000514.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs00381-014-2575-4"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00381-014-2575-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00381-014-2575-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00381-014-2575-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00381-014-2575-4'
This table displays all metadata directly associated to this object as RDF triples.
391 TRIPLES
21 PREDICATES
72 URIs
40 LITERALS
28 BLANK NODES