Cardiac involvement in coronavirus disease 2019 assessed by cardiac magnetic resonance imaging: a meta-analysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-03-16

AUTHORS

Shingo Kato, Mai Azuma, Kazuki Fukui, Sho Kodama, Naoki Nakayama, Hideya Kitamura, Eri Hagiwara, Takashi Ogura, Nobuyuki Horita, Ho Namkoong, Kazuo Kimura, Kouichi Tamura, Daisuke Utsunomiya

ABSTRACT

In this systematic review and meta-analysis, we sought to evaluate the prevalence of cardiac involvement in patients with COVID-19 using cardiac magnetic resonance imaging. A literature review was performed to investigate the left ventricular (LV) and right ventricular (RV) ejection fraction (EF), the prevalence of LV late gadolinium enhancement (LGE), pericardial enhancement, abnormality on T1 mapping, and T2 mapping/T2-weighted imaging (T2WI), and myocarditis (defined by modified Lake Louis criteria). Pooled mean differences (MD) between COVID-19 patients and controls for LVEF and RVEF were estimated using random-effects models. We included data from 10.462 patients with COVID-19, comprising 1.010 non-athletes and 9.452 athletes from 29 eligible studies. The meta-analysis showed a significant difference between COVID-19 patients and controls in terms of LVEF [MD = − 2.84, 95% confidence interval (CI) − 5.11 to − 0.56, p < 0.001] and RVEF (MD = − 2.69%, 95% CI − 4.41 to − 1.27, p < 0.001). However, in athletes, no significant difference was identified in LVEF (MD = − 0.74%, 95% CI − 2.41 to − 0.93, p = 0.39) or RVEF (MD = − 1.88%, 95% CI − 5.21 to 1.46, p = 0.27). In non-athletes, the prevalence of LV LGE abnormalities, pericardial enhancement, T1 mapping, T2 mapping/T2WI, myocarditis were 27.5% (95%CI 17.4–37.6%), 11.9% (95%CI 4.1–19.6%), 39.5% (95%CI 16.2–62.8%), 38.1% (95%CI 19.0–57.1%) and 17.6% (95%CI 6.3–28.9%), respectively. In athletes, these values were 10.8% (95%CI 2.3–19.4%), 35.4% (95%CI − 3.2 to 73.9%), 5.7% (95%CI − 2.9 to 14.2%), 1.9% (95%CI 1.1–2.7%), 0.9% (0.3–1.6%), respectively. Both LVEF and RVEF were significantly impaired in COVID-19 patients compared to controls, but not in athletes. In addition, the prevalence of myocardial involvement is not negligible in patients with COVID-19. More... »

PAGES

1570-1582

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-022-02055-6

DOI

http://dx.doi.org/10.1007/s00380-022-02055-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1146314099

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35294611


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    "description": "In this systematic review and meta-analysis, we sought to evaluate the prevalence of cardiac involvement in patients with COVID-19 using cardiac magnetic resonance imaging. A literature review was performed to investigate the left ventricular (LV) and right ventricular (RV) ejection fraction (EF), the prevalence of LV late gadolinium enhancement (LGE), pericardial enhancement, abnormality on T1 mapping, and T2 mapping/T2-weighted imaging (T2WI), and myocarditis (defined by modified Lake Louis criteria). Pooled mean differences (MD) between COVID-19 patients and controls for LVEF and RVEF were estimated using random-effects models. We included data from 10.462 patients with COVID-19, comprising 1.010 non-athletes and 9.452 athletes from 29 eligible studies. The meta-analysis showed a significant difference between COVID-19 patients and controls in terms of LVEF [MD\u2009=\u2009\u2212 2.84, 95% confidence interval (CI) \u2212 5.11 to \u2212 0.56, p\u2009<\u20090.001] and RVEF (MD\u2009=\u2009\u2212 2.69%, 95% CI \u2212 4.41 to \u2212 1.27, p\u2009<\u20090.001). However, in athletes, no significant difference was identified in LVEF (MD\u2009=\u2009\u2212 0.74%, 95% CI \u2212 2.41 to \u2212 0.93, p\u2009=\u20090.39) or RVEF (MD\u2009=\u2009\u2212 1.88%, 95% CI \u2212 5.21 to 1.46, p\u2009=\u20090.27). In non-athletes, the prevalence of LV LGE abnormalities, pericardial enhancement, T1 mapping, T2 mapping/T2WI, myocarditis were 27.5% (95%CI 17.4\u201337.6%), 11.9% (95%CI 4.1\u201319.6%), 39.5% (95%CI 16.2\u201362.8%), 38.1% (95%CI 19.0\u201357.1%) and 17.6% (95%CI 6.3\u201328.9%), respectively. In athletes, these values were 10.8% (95%CI 2.3\u201319.4%), 35.4% (95%CI \u2212 3.2 to 73.9%), 5.7% (95%CI \u2212 2.9 to 14.2%), 1.9% (95%CI 1.1\u20132.7%), 0.9% (0.3\u20131.6%), respectively. Both LVEF and RVEF were significantly impaired in COVID-19 patients compared to controls, but not in athletes. In addition, the prevalence of myocardial involvement is not negligible in patients with COVID-19.", 
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24 schema:description In this systematic review and meta-analysis, we sought to evaluate the prevalence of cardiac involvement in patients with COVID-19 using cardiac magnetic resonance imaging. A literature review was performed to investigate the left ventricular (LV) and right ventricular (RV) ejection fraction (EF), the prevalence of LV late gadolinium enhancement (LGE), pericardial enhancement, abnormality on T1 mapping, and T2 mapping/T2-weighted imaging (T2WI), and myocarditis (defined by modified Lake Louis criteria). Pooled mean differences (MD) between COVID-19 patients and controls for LVEF and RVEF were estimated using random-effects models. We included data from 10.462 patients with COVID-19, comprising 1.010 non-athletes and 9.452 athletes from 29 eligible studies. The meta-analysis showed a significant difference between COVID-19 patients and controls in terms of LVEF [MD = − 2.84, 95% confidence interval (CI) − 5.11 to − 0.56, p < 0.001] and RVEF (MD = − 2.69%, 95% CI − 4.41 to − 1.27, p < 0.001). However, in athletes, no significant difference was identified in LVEF (MD = − 0.74%, 95% CI − 2.41 to − 0.93, p = 0.39) or RVEF (MD = − 1.88%, 95% CI − 5.21 to 1.46, p = 0.27). In non-athletes, the prevalence of LV LGE abnormalities, pericardial enhancement, T1 mapping, T2 mapping/T2WI, myocarditis were 27.5% (95%CI 17.4–37.6%), 11.9% (95%CI 4.1–19.6%), 39.5% (95%CI 16.2–62.8%), 38.1% (95%CI 19.0–57.1%) and 17.6% (95%CI 6.3–28.9%), respectively. In athletes, these values were 10.8% (95%CI 2.3–19.4%), 35.4% (95%CI − 3.2 to 73.9%), 5.7% (95%CI − 2.9 to 14.2%), 1.9% (95%CI 1.1–2.7%), 0.9% (0.3–1.6%), respectively. Both LVEF and RVEF were significantly impaired in COVID-19 patients compared to controls, but not in athletes. In addition, the prevalence of myocardial involvement is not negligible in patients with COVID-19.
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30 schema:keywords COVID-19
31 COVID-19 patients
32 LV late gadolinium enhancement
33 LVEF
34 RVEF
35 T1 mapping
36 T2-weighted imaging
37 T2WI
38 abnormalities
39 addition
40 athletes
41 cardiac involvement
42 cardiac magnetic resonance imaging
43 control
44 coronavirus disease 2019
45 data
46 differences
47 disease 2019
48 ejection fraction
49 eligible studies
50 enhancement
51 fraction
52 gadolinium enhancement
53 imaging
54 involvement
55 late gadolinium enhancement
56 left ventricular
57 literature review
58 magnetic resonance imaging
59 mapping
60 mean difference
61 model
62 myocardial involvement
63 myocarditis
64 patients
65 pericardial enhancement
66 prevalence
67 random-effects model
68 resonance imaging
69 review
70 right ventricular ejection fraction
71 significant differences
72 study
73 systematic review
74 terms
75 terms of LVEF
76 values
77 ventricular
78 ventricular ejection fraction
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