Safety evaluation of high-risk myocardial micro-biopsy in a swine model View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2021-11-23

AUTHORS

Arvin Chireh, Mikael Sandell, Rikard Grankvist, Victoria Lövljung, Jonathan al-Saadi, Fabian Arnberg, Johan Lundberg, Magnus Settergren, Staffan Holmin

ABSTRACT

The objective of the study was to investigate the safety profile of high-risk micro-endomyocardial biopsy (micro-EMB) compared to conventional EMB in a large animal model. Twenty pigs were subjected to a maximum of 30 consecutive biopsies, including sampling from the free ventricular wall, with either micro-EMB (n = 10) or conventional EMB (n = 10). There were no major complications in the micro-EMB group (0/10), compared to six major complications in the EMB group (6/10; p = 0.003). Survival analysis further highlighted these differences (p = 0.004). There were significantly higher volumes of pericardial effusion in the EMB group (p = 0.01). The study shows a safety advantage of micro-EMB compared to standard EMB in the experimental high-risk circumstances investigated in this animal study. These results indicate enhanced possibilities to collect samples from sensitive areas by using the micro-EMB technique instead of standard EMB. More... »

PAGES

697-704

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-021-01995-9

DOI

http://dx.doi.org/10.1007/s00380-021-01995-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1142740490

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34812914


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