Frequency, predictors, and effect of the slow-flow phenomenon after drug-coated balloon angioplasty for femoropopliteal lesions View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2021-05-29

AUTHORS

Shigemitsu Shirai, Keisuke Hirano, Shinsuke Mori, Kenji Makino, Yosuke Honda, Masakazu Tsutsumi, Yasunari Sakamoto, Norihiro Kobayashi, Motoharu Araki, Masahiro Yamawaki, Yoshiaki Ito

ABSTRACT

Drug-coated balloon (DCB) angioplasty for femoropopliteal (FP) lesions has been available in Japan since 2018. In daily practice, we encountered cases of the slow-flow phenomenon after DCB angioplasty. However, no data regarding the slow-flow phenomenon after DCB angioplasty for FP lesions are available. This study aimed to investigate the frequency, predictors, and effect of the slow-flow phenomenon following DCB angioplasty for FP lesions. This single-center, retrospective, observational study analyzed 88 FP lesions treated by DCB angioplasty between April 2018 and July 2019. Patients were divided into the slow-flow group (n = 7) and non-slow-flow group (n = 81) and were analyzed. The primary endpoint was primary patency at 6 months. The slow-flow phenomenon was observed in seven cases (8.0%). The slow-flow group had higher incidence rates of critical limb ischemia (CLI) (71% vs. 25%, p < 0.01), chronic total occlusion (CTO) lesions (86% vs. 26%, p < 0.01), and poor tibial vessel runoff (86% vs. 33%, p < 0.01) and had a longer DCB length (237 ± 56 mm vs. 159 ± 97 mm, p = 0.03) than the non-slow-flow group. The primary patency rate at 6 months was 71% in the slow-flow group and 91% in the non-slow-flow group (p = 0.09). The rate of freedom from target lesion revascularization at 6 months was 71% in the slow-flow group and 97% in the non-slow-flow group (p < 0.01). The amputation-free survival rate at 6 months was 71% and 95% (p = 0.02), whereas the survival rate at 6 months was 71% and 95% (p = 0.02). The incidence rate of the slow-flow phenomenon after DCB angioplasty for FP lesions was 8.0%. CLI, a CTO lesion, poor tibial vessel runoff, and total DCB length were associated with the slow-flow phenomenon. Our results indicate that the slow-flow phenomenon is associated with poor short-term clinical outcomes. More... »

PAGES

1818-1824

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00380-021-01871-6

DOI

http://dx.doi.org/10.1007/s00380-021-01871-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1138463762

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/34050788


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39 drug-coated balloon angioplasty
40 effect
41 endpoint
42 femoropopliteal lesions
43 flow group
44 freedom
45 frequency
46 group
47 high incidence rate
48 incidence rate
49 ischemia
50 length
51 lesion revascularization
52 lesions
53 limb ischemia
54 months
55 observational study
56 occlusion lesions
57 outcomes
58 patency
59 patency rates
60 patients
61 phenomenon
62 poor short-term clinical outcome
63 practice
64 predictors
65 primary endpoint
66 primary patency
67 primary patency rate
68 rate
69 rate of freedom
70 results
71 revascularization
72 runoff
73 short-term clinical outcomes
74 slow flow group
75 slow flow phenomenon
76 study
77 survival rate
78 target lesion revascularization
79 tibial vessel runoff
80 total occlusion lesions
81 vessel runoff
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